C-myc
Presented by Tavia Clark
c-Myc: The Quintessential Oncogene
• Transcription factor involved in:– Cell growth – Cell proliferation– Repression of gene transcription– Apoptosis– Angiogenesis
TABLE 1 Growth inhibition and apoptosis following treatment with antisense oligonucleotides to c-myc
Growth inhibition Apoptosis
Cell or Tumor in vivo in vitro in vivo in vitro Reference
Human acute lymphoblastic leukemia
(CEM-C7) + + 18
Burkitt's lymphoma lines 30
Ramos (EBV−) + +
Daudi (EBV+) + −
Small cell lung cancer lines
GLC4, GLC4-cDDPa, GLC4-Adr + − 46
Human erythroblasts + − 47
Human CML blastsb + + ? ? 48
Melanoma linesc + + + + 49, 50
Thyroid cancer lines + ? 51
Orbital fibroblasts + − 52
Monomyeloid cells (HL-60) + + 36
Burkitt's lymphoma (Daudi, ST486) + ? 53
Ovarian cancer lines + +e 54d
Lymphoma U937 + 55e
Breast Cancer MCF-7 + 55
Ewing's sarcoma CHP-100 + 55
Burkitt's lymphoma ST-486 + 55
Breast cancer (MCF-7, MDA-MB-231) + ? 56
Human T lymphocytes
+IL-2 or PHA + − 57
Burkitt lymphomas (ST486, JD38) + ? 58
Hematopoietic cells + ? 59
Esophageal cancer cells + + 44
*Symbols: +, effect tested for and seen; −, effect tested for and not seen; ?, not tested (or not reported)
Links
• http://arjournals.annualreviews.org/doi/full/10.1146/annurev.physiol.60.1.575?cookieSet=1
• http://www.myccancergene.org/index.asp
• http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1550296
• http://www.sciencedirect.com/science?_ob=ArticleURL&_udi=B6T23-44Y0Y3F-1&_user=130907&_rdoc=1&_fmt=&_orig=search&_sort=d&view=c&_acct=C000004198&_version=1&_urlVersion=0&_userid=130907&md5=aa23778ee7ca3420a6b4cb277d165126
• http://www.tumor-gene.org/cgi-bin/TGDB/tgdb_fetch_gene.cgi?gene=myc
• http://www.cancerindex.org/geneweb/MYC.htm
• http://news-service.stanford.edu/news/2004/october13/med-felsher-1013.html
Articles• Bruno Amati, Konstantinos Alevizopoulos and Jaromir Vlach, “MYC
and the Cell Cycle,” Frontiers in Bioscience, 3, d250-268 (1998)• Jonas A Nilsson and John L Cleveland, “Myc pathways provoking
cell suicide and cancer,” Oncogene, 22, 9007-9021 (2003)• J Craig Cohen, et. al. “Transient in utero knockout (TIUKO) of C-
MYC affects late lung and intestinal development in the mouse,” BMC Developmental Biology, 4:4 (2004)
• E. Brad Thompson, “The many roles of c-Myc in apoptosis,” Annual Review of Physiology, 60, 575-600 (1998)
• Werner Lutz, Javier Leon and Martin Eilers, “Contributions of Myc to tumorigenesis,” BBA Reviews on Cancer, 1602:1, 61-71 (2002)
• Amy Adams “Switching off cancer gene turns cells healthy in mice,” Sanford Report, October 13, 2004
• Bruna Pucci, Margaret Kasten, and Antonio Giordano, “Cell cycle and apoptosis,” Neoplasia 2:4, 291-299 (2000)