Cell-Mediated CytotoxicityCytotoxic T-Lymphocytes
Natural Killer Cells
Antibody-Dependent, Cell-mediated Cytotoxicity
Delayed-type Hypersensitivity
Folder Title: CellKill
KillTitl
Updated: November, 25, 2004
Cell-Mediated Immunity (CMI):Passive transfer from donor to recipient of cells alone, transfers the immune response function
Response to:
Neoplastic (cancer) Cells
Infected or Altered Cells
Intra-cellular Pathogens
Fungi
Allo-grafts and other transplants
CMIRoles
Cell-Mediated Immunity (CMI):Types of Cytotoxic Cells
Antigen-Specific T-Cells (Have TCR): Tc : Cytotoxic T-Cells TDTH : Delayed-Type Hypersensitivity Cells ("Type IV Hypersensitivity")
Non-Antigen-Specific Cells: Macrophages NK Cells Granulocytes: Neutrophils, Eosinophils, Basophils and Tissue Mast Cells
CMICells
CTL Antigen Recognition
CD4 & CD8 Sensitize & Effect
CTL Sensitizaton Phase
CTL & MHC
Effector Phase by CTL
CTL & ICAM-1
CTL binding to Target Cell
Cytotoxic T-Cell Binding to Target Cell(figure 16-6, Kuby, 3rd Edition)
TC = Target Cell for Cytolytic T-Cell
Smaller Cell = CTL
CTLandTC
CTL Perforin Pore
T-Cell Killing by Induction of Apoptosis(figure 16-8, Kuby, 3rd Edition)
ICE = Interleukin 1Converting Enzyme
Signals Activationof Apoptosis
CTL&Apop
T-Cell and NK Cell Development
Comparison of T- and NK Cells
Natural Killer Cell Targets and Restriction to Altered-Self(Figure 16-11, Kuby, 3rd Edition)
No Killing
(Recognized Self;
MHC Class I)
Target Cell Killed
(Did not recognize self;
low MHC Class I
NKTarget
ADCC Targets
CD28 – B7 Co-stimulators
B7 Melanoma Vaccine