Cesar A. HidalgoCenter for Complex Network Research, University of Notre Dame / Northeastern University
The Human PhenotypicDisease Network
CollaboratorsNicholas ChristakisLaurie MeneadesJason Block
Dept. of Health Policy,Harvard Medical School
Laszlo BarabasiNicholas BlummDeok-Sun LeeJ Park
Center for Network Science,Northeastern University
Christine Teutsch
Massachusetts General HospitalHarvard Medical School
Some Diseases are known to be related
ENPP1 HFCS SLS
Ectonuclide Pyrophosphate
Phosphodiesterase 1
High FructoseCorn Syrup
SedentaryLife Style
There are no single causes for each disease
DiabetesObesity
Determining causes is labor and capital intensive
Disease 2Disease 1
Disease 1 Disease 2Affect Same Individuals
Significantly more than Random
C12
P1 P2
N
))(( jiji
jiijij
PNPNPP
PPNC
Building a Net
~ 13’039’018 patients58.3% females,90.1% white7.5% black
~ 32’341’348 records (hospitalizations)
Up to 10 diagnosis (from ~950 cat (3digit) / ~14000 (5digit) )
Disease 2Disease 1
CHF
CONCLUSIONS• We introduced the concept of a phenotypic
disease network.
• This network can be used to help explore life cycle strategies for drug companies and hospital design.
• This network can be used to perform comparative studies.
• Ultimately, the goal is to help determine disease ontology based on their comorbidity patterns
http://www.nd.edu/~chidalgo
Or Google: CA Hidalgo
http://www.nd.edu/~networks
Or Google: CCNR