Idit Shachar 25/5/15 1
CURRICULUM VITAE
Idit Shachar, Ph.D.
Incumbent of the Dr. Morton And Anne Kleiman
Professorial Chair
Head, Department of Immunology
Weizmann Institute
Rehovot, Israel 76100
PERSONAL DETAILS
Place and date of birth: Israel, September 4th 1964
Marital status: Married with two children (16, 8)
Military service: 1982-1984, second lieutenant
Contacts: Phone: 08-9344257
E-mail: [email protected]
Home page: http://www.weizmann.ac.il/immunology/IditShachar/
EDUCATION
1993-1997 Post doctoral fellow with Dr. R.A. Flavell, Yale School of Medicine.
1989-1993 Ph.D., Biochemistry
Tel-Aviv University, The George S. Wise Faculty of Life Sciences.
Thesis title:
"The Molecular Basis for Sorting, Transport and Secretion of IgM" under the
supervision of Dr. Shoshana Bar-Nun.
1987-1989 M.Sc., with honor, Biochemistry
Tel-Aviv University, The George S. Wise Faculty of Life Sciences, under the
supervision of Dr. Shoshana Bar-Nun.
1984-1987 B.Sc., with honor, Biology
Tel-Aviv University, The George S. Wise Faculty of Life Sciences.
Idit Shachar 25/5/15 2
EMPLOYMENT HISTORY
2013-present Full Professor in the Department of Immunology, The Weizmann Institute of
Science.
2004- 2013 Associate Professor in the Department of Immunology, The Weizmann institute of
Science.
1998-2004 Senior Scientist in the Department of Immunology, The Weizmann institute of
Science.
1989 Guest scientist with Dr. R. Fine, Boston University
Medical Center (four months)
OTHER APPOINTMENTS
2014- Chair, 2015 EMBO-ESF on B cells
2014- President of the Israel Immunological Society
2014- Head, department of Immunology
2012-2013 Vice-chair, 2013 EMBO-ESF on B cells
2012-2014 Vice president of the Israel Immunological Society
2009-2014 Head of the theses committee
2006-2014 Treasurer of the Israel Immunological Society
Membership in National and International Academic Committees and Societies
2007-2014 Member in the Katzir Fellowship committee.
2006-2014 Member in the Theses committee.
2007-2010 Member in the FEBS fellowship committee.
2007-2010 Member in the Research and Administration Service Committee.
1998-present American association of Immunologists, Board Member.
1998-present Israel Immunological Society, Board Member
Membership in scientific advisory boards and consulting activities
2008-2010 Consulting to CytoD, Meytav technology incubator
Idit Shachar 25/5/15 3
Teaching
1998- present Faculty courses in Immunology, teaching the B cell part.
1999-2002 Annual advanced Laboratory Course, The Weizmann Institute of Science.
RECOGNITION
Prizes and Awards
2005 Incumbent of the Dr. Morton and Anne Kleiman Professorial Chair.
2003 Teva prize for excellent research
2001 ISF prize for advancing education and science.
2000 Incumbent of The Alvin and Gertrude Levine Career Development Chair of Cancer
Research
1997 Alon foundation, young scientist fellowship.
1995-1998 Irvington Institute for Medical Research. USA. Post-Doctoral Fellowship
1993-1994 Rothschild foundation, Israel. Post-Doctoral Fellowship
1993 Wolf Foundation award.
1991 ASCB meeting, Travel award.
1989-1993 Faculty of Life Sciences, Tel-Aviv University, Dean's Graduate award.
1983-1988 Dean’s honor.
International Conferences organizing committees
2015 EMBO-ESF conference: ”Be There Or Die? The Role Of The
Microenvironment In B Cell Behaviour In Health And Disease” Spain
2015 FEBS workshop: “ Inflammation, the bonfire from within”, Israel
2015 MIF international meeting
2015 Annual meeting of the Israel Immunological Society
2013 EMBO-ESF conference: ” B cells from bedside to bench and back” , Poland
2012 FEBS workshop: “Decisions in the life of immune cells”, Israel
2010 The 32nd Annual Katzir-Katchalsky conference: “Immunity in context”, Israel.
2007 Annual meeting of the Israel Immunological Society
Idit Shachar 25/5/15 4
Invited Lectures and Chairmanship in International Scientific Meetings and seminars (five
years)
2015 1. FEBS workshop: “ Inflammation, the bonfire from within”, Weizmann Institute,
Rehovot, Israel. Organizer and speaker.
2. International MIF meeting, Rehovot, Israel, organizer and speaker.
3. “B cells: Immunity and Autoimmunity“, Erlangen, Germany- Invited speaker.
4. Richard Flavell 70’s birthday. Invited speaker.
5. Eurpean congress of Immunology 2015. Workshop’s chair.
6. EMBO-ESF conference: ”Be There Or Die? The Role Of The Microenvironment
In B Cell Behaviour In Health And Disease” Spain. Chair and speaker.
7. Annual meeting of the Israel Immunological Society- Organizer.
8. ISF workshop- “Prospects of Immunity for Precision Cancer Medicine,
Jerusalem, Israel. Invited speaker.
9. The 2nd Joint Symposium of the Trinity Biomedical Sciences institute and the
Weizmann institute of Science- Organizer and speaker.
2014 1. Ilanit 2014- session chair and speaker.
2. International MIF meeting, Lausanne, Switzerland-invited speaker.
3. 3rd excellence in Midkine research conference, Kyoto, Japan-invited speaker.
4. "Inflammation and cancer- fast moving fields inbiomedicine yielding new
therapies", Dublin, Ireland- Invited speaker.
2013 1. ESF-EMBO:” B cells from bedside to bench and back”, Poland, Co-chair and a
speaker.
2. National Human Genome Research Institute, NIH, Bethesda, MD.
3. Weizmann-Karolinska Institute Symposium: Weizmann Institute, Rehovot,
invited speaker.
2012 1. IUBMB and FEBS 2012 Congress, Seville, Spain. Invited symposium speaker.
2. FEBS meeting:” Decisions in the life of immune cells” Israel, Organizer and
speaker.
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3. 2nd excellence in Midkine research conference, Istanbul, Turkey. Invited Speaker.
4. “International MIF symposium” Louisville, KT, USA. Invited speaker.
5. “MIF in Health and Disease” Mumbai, India, Invited speaker.
6. Annual meeting of the Israel Immunological Society. Chair
2011 1. ESF-EMBO: B cells and Protection: Back to Basics, Spain. Invited speaker.
2. Manchester-Weizmann meeting, Manchester, England. Invited speaker.
3. Department of experimental Immunology and Hematology, the Academic
Medical Center Amsterdam, University of Amsterdam, the Netherlands
4. “International MIF symposium” New-Haven, CT, U.S.A. Invited speaker.
5. First French-Israeli International Meeting on B cells and Therapeutic
Antibodies, Jerusalem, Israel. Invited Speaker.
6. Second meeting on B cells and Autoimmunity, Haifa, Israel. Invited Speaker.
2010 1. Strasburg-Weizmann symposium. Weizmann Institute, Rehovot, Israel.
2. Department of Lymphoma/Myeloma, The University of Texas MD
Anderson Cancer Center, Houston Texas, U.S.A.
3. “Immunity in context” Weizmann Institute, Rehovot, Israel. Organizer and
speaker.
4. 6th International Symposium on “Cytokine Signaling” Aachen, Germany.
Invited speaker.
2009 1. Keystone meeting: “B cells in context”. Workshop speaker.
2. Marie Curie conference: ”Immunology of HIV and TB infection”
Stockholm, Sweden, invited speaker.
3. DFG sponsored Collaborative Research Center on Immunodeficiency (SFB
620): “New Developments in Immunodeficiency Research” Freiburg,
Germany, invited speaker.
4. Department of Pathology and Laboratory Medicine, Weill Medical College
of Cornell University, New York, U.S.A.
5. “International MIF symposium” Schloß Hochhausen, Germany, invited
speaker.
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6. “The essential role of B cells in autoimmune diseases”, Technion, Haifa
Israel. Invited speaker.
2008 1. McGill Weizmann symposium: “Cancer-a cellular and molecular view”,
Rehovot, Israel, Invited speaker.
2. New York University School of Medicine, Skirball Institute of
Biomolecular Medicine, NY, U.S.A.
3. Laboratory for Immunological and Molecular Cancer Research, LIMCR
Federal Hospital Salzburg, Salzburg, Austria
SCIENTIFIC PRODUCTIVITY
Competitive National and International Grants (last 5 years)
Years Agency Sum
2015-2018 DKFZ-IMOS 130,000 Euro
2014-2017 BSF 90,000$
2014-2015 Merck 300,000 Euro
2012-2014 ICRF 60,000$
2011-2013 Kamin 200,000$
2011-2015 Israel Science Foundation 200,000$
2011-2012 Israel Cancer Association 50,000$
2009-2011 Israel Science Foundation 100,000$
2008-2011 Israel Science Foundation-Morasha 150,000$
2007-2010 Minerva 150,000$
2005-2008 EU 50,000 Euro
2005-2006 Israel Cancer Association 10,000$
2005-2008 Israel Science Foundation 120,000$
2004-2008 EU 90,000 Euro
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Present and former graduate students and staff
Name Years Position
Lital Server 2014-2016 postdoc
Hadas Lewinsky 2014-2015 M.Sc.
Avital Barak 2014-2018 Ph.D.
Lihi Radomir 2013-2017 Ph.D.
Mattias Kramer 2013-2015 postdoc
Naama Gil 2012-2016 Ph.D.
Maya Yaskovich-Gordin 2012 postoc
Nimrod Hazan 2011-2012 M.Sc.
Inbal Binsky 2010-2011 postdoc
Ezster Bakos 2010-2015 Ph.D.
Ayelet Marom 2009-2014 Ph.D.
Yoni Lati 2008-2009 M.Sc.
Sivan Cohen 2008-2012 Ph.D.
Einat Zelman 2006-2011 Direct Ph.D.
Maya Yaskovich 2006-2011 Direct Ph.D.
Inbal Binsky 2005-2010 Direct Ph.D.
Anita Sapoznikov 2005-2009 Ph.D.
Tamar Avin 2005-2006 M.Sc.
Shirly Becker-Herman 2004-2005 postdoc
Yael Gore 2004-2009 Ph.D.
Galit Arie 2002-2003 M.Sc.
Helena Medvedovsky 2002-2003 M.Sc.
Gili Hart 2002-2007 Ph.D.
Gili Hart 2001-2002 M.Sc.
Liat Flaishon 2000-2004 Ph.D.
Anat Kerem-Angel 1999-2002 postdoc
Shirly Becker-Herman 1999-2004 Ph.D.
Didi Matza 1998-2002 Ph.D.
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Referee for research grants and journals
Grants: Swiss Science Foundation; French National Research Agency; Germany-
Israel Foundation (GIF); Israel Cancer Association; Israel Ministry of
Health; Israel Science Foundation (ISF); United States-Israel Binational
Science Foundation (BSF)
Journals: Immunity, Blood, Proc. Natl. Acad. Sci U.S.A., Journal of Immunology,
European Journal of Immunology, Journal of Biochemical Chemistry,
Journal of Leukocyte Biology, Hepatology, Journal of Internal Medicine,
Haematologica, Clinical Cancer Research, International Immunology,,
FEBS Letters, Immunology letters, Steroids, Mediators of Inflammation.
Idit Shachar 25/5/15 9
PATENTS
1. “Method and Pharmaceutical composition for treating inflammation” United States patent
No. 6,911,198, granted June 28th, 2005.
2. “CCL2, as an anti-inflammatory compound for the treatment of inflammation”. In
registration process in the USA patent office.
3. “CD84 as a survival receptor in tumor cells”. In registration process in the USA patent
office.
4. “Methods for treating inflammation; CD151 as a regulator of T cell homing and
inflammation”. In registration process in the USA patent office.
5. “CD151 extracellular domain as a blocker of CD151 activity and inflammation”. In
registration process in the USA patent office.
I. Languages
Hebrew 3
English 3
Idit Shachar 25/5/15 10
List of Publications:
1. Amitay R., Bar-Nun S., Haimovitch J., Rabinovitch E. and Shachar I. (1991) “Post-
Translational Regulation of IgM Expression in B lymphocytes”. J. Biol. Chem. 266:
12568-12572.
2. Morin P.J., Johnson R.J., Shachar I., Fine R.E. and Leeman S.E. (1991)
“Characteristics of Tachykinin Transport Vesicles in the Optic Nerve”. Ann. NY.
Acad. Sci. 632: 442-443.
3. Shachar I., Amitay R., Rabinovitch E., Haimovitch J. and Bar-Nun S. (1992)
“Polymerization of Secretory IgM in B Lymphocytes is Prevented by a Preceding
Targeting to a Degradation Pathway” .J. Biol. Chem. 267: 24241- 24247.
4. Amitay R., Shachar I., Rabinovitch E., Haimovitch J. and Bar-Nun S. (1992)
“Degradation of Secretory IgM in B Lymphocytes Occurs in a post-Endoplasmic
Reticulum Compartment and is Mediated by a Cysteine Protease”. J. Biol. Chem. 267:
20697-20700.
5. Rabinovitch E., Bar-Nun S., Amitay R., Shachar I., Gur B., Taya M. and Haimovitch
J. (1993) “Different Assembly Species of IgM are Directed to Distinct Degradation
Sites Along the Secretory Pathway”. J. Biol. Chem. 268: 24145-24148.
6. Shachar I., Rabinovitch E., Kerem A. and Bar-Nun S. (1993) “Thiol Reducing
Agents and Calcium Perturbants Alter the Intracellular Sorting of IgM”. J. Biol.
Chem. 269: 27344- 27350.
7. Shachar I., Elliott E.A., Chasnoff B., Grewal I.S. and Flavell R.A. (1995)
“Reconstitution of Invariant Chain Function in transgenic Mice in vivo by Individual
p31 and p41 Isoforms”. Immunity 3: 373-383.
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8. Winitz D., Shachar I., Elkabetz Y., Samuelov M. and Bar-Nun S. (1996)
“Degradation of Distinct Assembly Forms of Immunoglobulin M Occurs in Multiple
Sites in Permeabilized B Cells”. J. Biol. Chem. 271: 27645-27651.
9. Shachar I. and Flavell R.A. (1996) “Invariant Chain is Required for B Cells
Maturation and Function”. Science 274: 106-108.
10. Pierre P*., Shachar I.*, Matza D., Gatti E., Flavell R.A. and Mellman I. (2000)
“Invariant Chain Controls H2-M Proteolysis in Mouse Splenocytes and Dendritic
Cells”. J. Exp. Med 191: 1057-1062.
*Pierre and Shachar contributed equally to this work.
11. Flaishon L., Hershkovitz R., Lantner F., Lider O., Alon R., Levo Y., Flavell R.A. and
Shachar I. (2000) ”Autocrine Secretion of Interferon g Negatively Regulates Homing
of Immature B Cells”. J. Exp. Med. 192: 1381-1387.
12. Matza D., Wolstein O., Dikstein R. and Shachar I. (2001) “Invariant Chain Induces B
Cell Maturation by Activating TAFII105-NF-B Dependent Transcription Program”.
J. Biol. Chem. 276: 27203-27206.
13. Flaishon L., Lantner F., Hershkovitz R., Levo Y. and Shachar I. (2001) “Low Levels
of IFN- Down-regulate the Integrin-Dependent Adhesion of B cells by Inhibition of
Cytoskeleton Rearrangement”. J. Biol. Chem. 276: 46701-46706.
14. Topilski I., Harmelin A., Flavell R.A., Levo Y. and Shachar I. (2002) “Preferential
Th1 Immune Response in Invariant Chain- Deficient Mice“. J. Immunol. 168: 1610-
1617.
15. Matza D., Lantner F., Bogoch Y., Flaishon L., Hershkovitz R. and Shachar I. (2002)
“Invariant Chain Induces B cell Maturation in a Process Which is Independent of its
Chaperonic Activity”. Proc. Natl. Acad. Sci U.S.A. 99: 3018-3023.
Idit Shachar 25/5/15 12
16. Silkov A., Wolstein O., Shachar I. and Dikstein R. (2002) “Enhanced Apoptosis of B
and T Lymphocytes in TAFII105 Dominant Negative Transgenic Mice is Linked to
NF-kappaB”. J. Biol. Chem. 277: 17821-17829.
17. Flaishon L., Topilski I., Shoseyov D., Hershkoviz R., Fireman E., Levo Y., Marmor
S., and Shachar I. (2002) “Anti-Inflammatory Properties of Low Levels of IFN-g”. J.
Immunol.: Cutting edge: 168: 3707-3711.
18. Becker-Herman S., Lantner F. and Shachar I. (2002) “Id2 Negatively Regulates B
cell Differentiation in the Spleen”. J. Immunol. 168: 5507-5513.
19. Schori H., Lantner F., Shachar I.*, and Schwartz M.* (2002) “Severe
Immunodeficiency has Opposite Effects on Neural Survival in Glutamate-Susceptible
and Resistant Mice: Adverse Effect of B Cells”. J. Immunol. 169: 2861-2865.
*Equal contribution
20. Matza D., Kerem A., Medvedovsky H., Lantner F. and Shachar I. (2002) “Invariant
chain induced B cell differentiation requires intramembrane - proteolytic release of the
cytosolic domain”. Immunity 17: 549-560.
21. Hart G., Flaishon L., Becker-Herman S. and Shachar I. (2003) “The Ly49D receptor
expressed on immature B cells regulates their interferon gamma secretion, actin
polymerization and homing”. J. Immunol. 171: 4630-4638.
22. Topilski I., Flaishon L., Naveh Y., Harmelin A., Levo Y. and Shachar I. (2004) “The
anti-inflammatory effects of 1,25-Dihydroxyvitamin D3 on Th2 cells in vivo are due
in part to the control of integrin-mediated T lymphocyte homing”. Eur. J. Immunol.
34: 1068-1076.
23. Flaishon L., Becker-Herman S., Hart G., Levo Y. Kuziel W.A. and Shachar I. (2004)
“Expression of the Chemokine Receptor CCR2 on Immature B cells Negatively
Regulates their Cytoskeleton Rearrangement and Migration”. Blood 104: 933-941.
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24. Haran M., Chebatco S., Flaishon L., Lantner F., Harpaz N., Valinsky L. Berrebi A. and
Shachar I. (2004) “Grb7 expression and cellular migration in chronic lymphocytic
leukemia: a comparative study of early and advanced stage disease”. Leukemia
18:1948-1950.
25. Hart G., Flaishon L., Becker-Herman S. and Shachar I. (2005) “Tight regulation of
IFN- transcription and secretion in immature and mature B cells by the inhibitory
MHC class I receptor, Ly49G2”. J. Immunol. 175: 5034-5042.
26. Becker-Herman S., Arie G., Medvedovsky H., Kerem A. and Shachar I. (2005)
“CD74 is a member of the regulated intramembrane proteolysis (RIP) processed
protein family”. Mol. Biol. Cell 16:5061-5069.
27. Starlets D., Gore Y., Binsky I., Haran M., Harpaz N., Shvidel L., Becker-Herman S.,
Berrebi A. and Shachar I. (2006) “Cell Surface CD74 initiates a signaling cascade
leading to cell proliferation and survival” Blood 107: 4807-4816.
28. Wald O., Weiss I.D., Wald H., Shoham H., Bar-Shavit Y., Beyder K., Galun E., Weiss
L., Flaishon L., Shachar I., Nagler A., Lu B., Gerard C., Gao J.-L., Mishani E., Farber
J., and Peled A. (2006) “IFN-gamma Acts on T Cells to Induce NK Cell Mobilization
and Accumulation in Target Organs” J. Immunol. 176: 4716-4729.
29. Schori H., Shechter R., Shachar I. and Schwartz M. (2007) “Genetic manipulation of
CD74 in mouse strains of different backgrounds can result in opposite responses to
CNS injury” J. Immunol. 178: 163-171.
30. Hart G., Flaishon L. and Shachar I. (2007) “IL-12 and IL-18 downregulate B cell
migration in an Ly49D-dependent manner” Eur. J. Immunol.: 37: 1996-2007.
31. Binsky I., Haran M., Starlets D., Gore Y., Lantner F., Harpaz N., Leng L., Goldenberg
D.M., Shvidel L., Berrebi A., Bucala R., and Shachar I. (2007) “IL-8 secreted in a MIF
and CD74 dependent manner regulates B-CLL survival” Proc. Natl. Acad. Sci U.S.A.:
104: 13408-13413.
Idit Shachar 25/5/15 14
32. Lantner F., Starlets D., Gore Y., Flaishon L., Yamit-Hezi A., Dikstein R., Leng L.,
Bucala R., Machluf Y., Oren M. and Shachar I. (2007) “CD74 induces TAp63
expression leading to B cell survival” Blood 110: 4303-4311.
33. Hart G., Avin-Wittenberg T. and Shachar I. (2008) “IL-15 regulates immature B cell
homing in an Ly49D, IL-12, and IL-18 dependent manner” Blood 111: 50-59.
34. Gore Y., Starlets S., Maharshak N., Becker-Herman S., Kaneyuki U., Leng L., Bucala
R. and Shachar I. (2008) “Macrophage Migration Inhibitory Factor (MIF) Induces B
Cell Survival by Activation of a CD74/CD44 Receptor Complex” J. Biol. Chem 283:
2784-2792.
35. Sapoznikov A., Pewzner-Jung Y., Kalchenko V., Krauthgamer R., Shachar I.* and
Jung S.* (2008) “The Bone Marrow Immune Niche: Perivascular Dendritic cell
clusters provide critical B cell survival signals” Nat. Immunol.9: 388-395
(Commentaru in the same issue : Nagasawa T., (2008) “New niches for B cells” Nat.
Immunol. 9:345-346).
*Equal contribution
36. Flaishon L., Hart G., Zelman E., Moussion C., Grabovsky V., Lapidot Tal G.,
Feigelson S., Margalit R., Harmelin A., Avin- Wittenberg T., Shoseyov D., Alon R.,
Girard J.-P. and Shachar I. (2008) “Anti-inflammatory effects of an inflammatory
chemokine: CCL2 inhibits lymphocyte homing by modulation of CCL21 triggered
integrin-mediated adhesions” Blood 112: 5016-5025.
37. Hartmann TN., Grabovsky V., Wang W., Desch P., Rubenzer G., Wollner S., Binsky
I., Vallon-Eberhard A., Sapoznikov A., Burger M., Shachar I., Haran M.,
Honczarenko M., Greil R. and Alon R. (2009) “Circulating B-Cell Chronic
Lymphocytic Leukemia Cells Display Impaired Migration to Lymph Nodes and Bone
Marrow” Cancer Res 69: 3121-3130.
Idit Shachar 25/5/15 15
38. Berrih-Aknin S., Ruhlmann N., Bismuth J., Cizeron-Clairac G., Zelman E., Shachar
I., Dartevelle P., de Rosbo N.K., Le Panse R. (2009) “CCL21 overexpressed on
lymphatic vessels drives thymic hyperplasia in myasthenia” Ann Neurol. 66:521-31.
39. Maharshak N., Hart G., Ron E., Zelman E., Sagiv A., Arber N., Brazowski E.,
Margalit R., Elinav E., Shachar I. (2010) “CCL2 (pM levels) as a therapeutic agent in
inflammatory bowel disease models in mice” Inflammatory Bowl Diseases 16: 1496-
1504.
40. Maharshak N., Cohen S., Lantner F., Hart G., Leng L., Bucala R. and Shachar I.
(2010) “CD74 is a survival receptor on colon epithelial cells” World Journal of
Gastroenterology: 16: 3258-3266.
41. Binsky I., Lantner F., Grabovsky V., Harpaz N., Shvidel L., Berrebi A., Goldenberg
D.M., Leng L., Bucala R., Alon R., Haran M. and Shachar I. (2010) “TAp63
regulates VLA-4 expression and CLL cell migration to the BM in a CD74 dependent
manner” J. Immunol. 184: 4761-4769.
42. Gore Y., Lantner F., Hart G. and Shachar I. (2010) “Mad3 negatively regulates B cell
differentiation in the spleen by inducing Id2 expression” Mol. Biol. Cell 21: 1864-
1871.
43. Gordin M., Tesio M., Cohen S., Gore Y., Lantner F., Leng L., Bucala R. and Shachar
I. (2010) “c-Met and its ligand HGF regulate mature B cell survival in a pathway
induced by CD74” J. Immunol. 185: 2020-2031.
44. Manevich-Mendelson E., Grabovsky V., Feigelson S.W., Cinamon G., Gore Y.,
Goverse G., Monkley SJ, Margalit R, Melamed D., Mebius R.E., Critchley D.R.,
Shachar I., Alon R. (2010) “Talin1 is required for integrin-dependent B lymphocyte
homing to lymph nodes and the bone marrow but not for follicular B cell maturation in
the spleen” Blood 116: 5907-5918.
45. Lapter S., Ben-David H., Sharabi A., Zinger H., Telerman A., Gordin M., Leng L.,
Bucala R., Shachar I., Mozes E. (2011) “A role for the B-cell CD74/macrophage
Idit Shachar 25/5/15 16
migration inhibitory factor pathway in the immunomodulation of systemic lupus
erythematosus by a therapeutic tolerogenic peptide” Immunology 132: 87-95.
46. Cohen S., Shoshana O., Zelman-Toister, E., Maharshak N., Binsky- Ehrenreich I.,
Gordin M., Hazan-Halevy I, Herishanu Y., Shvidel L., Haran M., Leng L., Bucala R.,
Harroch S., Shachar I. (2012) “The Cytokine Midkine and its Receptor RPTP
Regulate B Cell Survival in a Pathway Induced by CD74” J. Immunol 188: 259-269.
47. Stepensky P., Keller B., Buchta M., Kienzler A.K., Elpeleg O., Somech R., Cohen
S., Shachar I., Miosge L.A., Schlesier M., Fuchs I., Enders A., Eibel H., Grimbacher
B., Warnatz K. (2013) “Deficiency of caspase recruitment domain family, member
11 (CARD11), causes profound combined immunodeficiency in human subjects” J.
Allergy Clin. Immunol. 131: 477-485.
48. Binsky-Ehrenreich I., Marom A., Sobotta M.C., Lantner F., Harpaz N., Shvidel L,
Berrebi A., Hazan-Halevy I., Herishanu Y, Aloshin A., Sagi I., Goldenberg D.M.,
Leng L., Bucala R., Haran M and Shachar I. (2014) “CD84 is a survival receptor for
CLL cells”. Oncogene 33: 1006-1016.
49. Klasen C., Ohl K., Sternkopf M., Shachar I., Schmitz C., Heussen N., Hobeika E.,
Levit-Zerdoun E., Tenbrock K., Reth M., Bernhagen J., El Bounkari O. (2014) “MIF
promotes B cell chemotaxis through the receptors CXCR4 and CD74 and ZAP-70
signaling” J. Immunol. 192: 5273-5284.
50. Zelman-Toister E., Bakos E., Cohen S., Zigmond E., Shezen E., Grabovsky V., Sagiv
A., Hart G., Kaushansky N., Ben-Nun A., Maharshak N., Sonnenberg A., Alon R.,
Becker-Herman S. and Shachar I. (2015) “CD151 regulates T cell migration and
homing in health and disease”. Inflammatory Bowel Diseases: In press
Invited reviews:
1. Matza D., Kerem A. and Shachar I. (2003) “Invariant chain, a chain of command”
Trends in Immunol. 24: 246-248.
Idit Shachar 25/5/15 17
2. Shachar I. and Haran M. (2011) “ The secret second life of an innocent chaperone:
The story of CD74 and B-cell/chronic lymphocytic leukemia (CLL) cell survival”.
Leukemia and lymphoma 52: 1446-14454.
3. Cohen S. and Shachar I. (2012) “Cytokines as regulators of proliferation and survival
of healthy and malignant peripheral B cells” Cytokine 60: 13-22.
4. Shachar I., Cohen S., Marom A. and Becker-Herman S. (2012) “Regulation of CLL
survival by hypoxia-inducible factor and its target genes” FEBS J. 586: 2906-2910.
5. Shachar I. and Karin N. (2013) “The dual roles of inflammatory cytokines and
chemokines in the regulation of autoimmune diseases and their clinical implications”
J. Leu Biol. 93: 51-61.
6. Cohen S., and Shachar I. (2014) “Midkine as a regulator of B cell survival in health
and disease” British Journal of Pharmacology.171: 888-895.
7. Bucala R. and Shachar I. (2015) “The integral role of CD74 in antigen presentation,
MIF signal transduction and B cell survival and homeostasis” Mini reviews in
Medicinal Chemistry. 14: 1132-1138.
Chapter in a book:
The MIF handbook: chapter “CD74, the natural receptor for MIF, regulates cell
survival in health and disease”. Word scientific press (2012).
Submitted papers:
Marom A, Barak A.F., Kramer M.P., Binsky-Ehrenreich I., Cohen S., Lewinsky H.,
Tsitsou-Kampeli A., Kalchenko V., Kuznetsov Y., Mirkin V., Dezorella N., Shapiro
M., Schwartzberg P.L., Cohen Y., Shvidel L., Haran M, Becker-Herman S.,
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