Aspects pidmiologiques du prlvement et de la transplantation dorganes en France et en Europe
Dfinitions etprincipaux chiffres
DfinitionsQuels types de donneurs?
Donneur cur battant/mort encphaliqueDonneur cur arrt(classification de Maastricht)
Donneur vivant dorganes, de tissus et de cellulesRsidus opratoires
Quels types de greffe?
AutogreffeAllogreffeApparenteNon apparenteXnogreffe
DeuxpopulationsDonneurs
Mort encphalique (trauma, AVC), cur arrt, vivants,
Malades
Insuffisance terminale dorgane (R, F (no), C, P)Insuffisance cellulaire (pancras, troubles neurologiques)Dficit fonctionnel avec ou sans handicap tissus corne, os massif,mains,faceComplment thrapeutique (bnfice)valves, ttes fmorales, vaisseaux, peauCancers hmatologiques, tumeurs solides chimiosensiblesAllo et Autogreffes de CSH quelle offre pour quelle demande?
CSHAuto, App, Non app, PlacMort encphaliqueCur arrt*Donneur vivantR. OprReinXXXFoieXXXCurX Cur PoumonX PoumonX (X)XPancrasX (X)IntestinX CorneXXPeauXXXXVaisseauxXXXXOs massifsXXTtes fmoralesXXTis compositesXQuel donneur pour quelle allogreffe?Valves cardXXXX
Quels volumes dactivit?
Feuil1
Donneurs ME : 1614Nombre de malades greffernombre de malades greffsNombre de malades dcds en attente
Organes total 2006126504408285
Cur70035667
Cur-Poumons702219
Poumons38818223
Foie1841103263
Rein93372718113
Pancras292900
Intestin2280
CSH Total 20044158
CSH autoloques3176
CSH allogniques982
Tissus 2004
Corne97644771
Peau24m
Vaisseaux798
Valves cardiaques205
Os massifs227
Ttes fmorales14209
Tissus compositesrech
Feuil2
Feuil3
Le droulement dun prlvement : organes et tissus
Organisation des prlvements
Dcret de 1998 et arrt des bonnes pratiques de prlvement dorganes sur donneur dcdEtablissements : Cadavre : tablissements de sant autoriss public ou privDonneur vivant : ncessit dtre autoris pour la greffe de lorgane considrAutorisation pour 5 ans (ARH)Possibilit de retrait ou de suspension (ARH)Praticiens : interdiction de rmunration lacte, sparation des quipes charges du constat de la mort et des transplanteurs, restauration du corps.Rfrent mdical (CME) coordination hospitalire infirmire (Directeur)
Rle de la coordinationIntervient en interne et en liaison avec un rseau dtablissementsRle central lhpital / ra /urgences/SAMU et autre services accueillant des ME (cardio-neuro)Recensement des donneurs potentielsRelations avec les famillesOrganisation de lactivit de PMO et de tissusVeille la scurit sanitaire / souvent coordonnateur de biovigilanceInformation et formation du personnel du CHMise en place des rseauxRelation troite et rgulire avec le SRA de lAgence de la biomdecine
La mort encphaliqueDCRET en Conseil d Etat du 2 dcembre 1996 prvoit les conditions du diagnostic de mort cur battant et cur non battant
Absence totale de conscience et d'activit motrice spontaneAbolition de tous les rflexes du tronc crbralAbsence totale de ventilation spontane vrifie par une preuve d'hypercapnie 2 lectroencphalogrammes nuls et aractifs effectus un intervalle minimal de 4 heures avec amplification maximale sur une dure d'enregistrement de 30 minutes attestant la destruction irrversible du cerveau Angiographie crbrale et/ou angioscanner
"Les mdecins qui tablissent le constat de la mort et ceux qui effectuent le prlvement ou la transplantation doivent faire partie d'units fonctionnelles ou de services distincts
Le procs-verbal du constat de la mort doit tre sign par deux mdecins
Le donneur cur arrt Classification de MaastrichtStade I les personnes qui sont retrouves en arrt cardiaque et pour lesquelles le prlvement dorganes est envisag, si la dure de larrt est brveStade II Arrt cardiaque en prsence des secours, bnficiant dun massage cardiaque avec ventilation mcanique et dont la ranimation choueStade III Arrt de la ranimation dcidStade IV Personnes en ME qui font un arrt cardiaque irrversibles au cours de la prise en charge en ranimation.
Suisse et Hollande III, Espagne et GB I et II
Le donSi le mdecin na pas directement connaissance de la volont du dfunt, il doit sefforcer de recueillir :- loi 1994 : le tmoignage de sa famille- loi 2004 : auprs des proches lopposition au don dorganes ventuellement exprime de son vivant par le dfunt, par tout moyen, et il les informe de la finalit des prlvements envisags.Les proches sont informs de leur droit connatre les prlvements effectus.Grands principes en matire de don Consentement prsum Interdiction de faire de la publicit Gratuit Anonymat donneur / receveur Scurit sanitaire
Les chanes du prlvement la greffe (organes/tissus)Hpital autoris prleverHHHSAMURseau DonneurCoord hosp Hpital autoris greffer org CHUBanque tissu autoriseGreffe tissus Hop publicGreffe tissus Hop privRgulation rpartition SRARsidus opratoiresLNA
Accueil d'un sujet en coma grave Diagnostic de la mort encphalique bilan de recherche dabsence de contre indications Bloc opratoire Organisation du prlvement Recueil du tmoignage Procureur de la Rpublique Centre autoris Rgulation Rpartition et attribution Famille du dfunt Coordination hospitalire Dfunt Processus de prise en charge dun donneurRNRSRAAnnoncedu dcsSRAquipesLNA
LischmieLa rgulation dun PMO dure en moyenne 24 h, du recensement dun patient en tat de mort encphalique la restitution du corpsDure dischmie froide cur, poumons 4-6 h foie6-10 h rein24-36 hTransports : ambulance, SNCF, avion
Quel encadrement gnral?
LAgence de la biomdecine
Etablissement public administratif de lEtat,cr par la loi du 6 aot 2004,place sous la tutelle du ministre de la sant etsuccde lEtablissement franais des greffes
Champ dactionle prlvement et la greffe des organes, tissus et celluleslassistance mdicale la procrationle diagnostic prnatal et gntiquela recherche sur lembryon et les cellules embryonnaires
Carte territoriale de lAgence de la biomdecine
Un encadrement rglementaire prcis
Dcret et arrts relatifs lautorisation des tablissements de santDcret et arrt sur les rgles de scurit sanitaireArrts portant homologation des rgles de bonnes pratiques Arrt portant homologation des rgles de rpartition des greffons..
Les apports de la loi de biothique du 6 aot 2004Le prlvement est une activit mdicale Le prlvement et la greffe constituent une priorit nationale Tous les tablissements de sant, quils soient autoriss ou non, participent lactivit de plvt dorganes et de tissus en sintgrant dans des rseaux de plvt La notion de consentement prsumLinformation des jeunes de 16 25 ans
Lextension du cercle des donneurs vivants
Loi 1994 : pre/mre, fils/fille, frre/sur
Loi 2004 : + conjoint, grands-parents, oncle/tante, cousins germains, conjoint du pre/mre, toute personne apportant la preuve dune vie commune dau moins deux ans avec le receveurAutorisation dun comit dexperts (sauf pre et mre)
Donneurs en mort encphaliqueActivit de prlvement et contexte pidmiologique
Le recensement et le prlvement2006 : 23,2 donneurs prlevs pmh, Espagne 33,6 pmh en 2005
Le recensement et le prlvementDisparits rgionales 2005
Evolution de la rpartition des causes de dcs des donneurs recenss
Evolution de la rpartition de lge des donneurs recenssAge moyen 1996 : 37,5 ans 2004 : 47,1 ans
Evolution des causes de non-prlvement
Contexte pidmiologiqueReceveurs : Vieillissement de la population : augmentation de la prvalence de lIRCT : 600 pmh dbut 1990, 866 pmh dont 513 en dialyse pmh 2003Estimation de 400-500 000 personnes avec une infection chronique VHC en France infects dans les annes 1970 et 80 (dlai?)Augmentation de la demande de greffe de poumon pour les malades avec une mucoviscidose : allongement de leur survie (effet cohorte)Donneurs :Diminution des dcs lis aux AVP Diminution des dcs par AVC Vieillissement de la population
Evolution du taux de mortalit standardis par causes violentes en France (p 100 000 hab)
Graph3
21.420.331.2
21.122.629.5
18.823.126.4
18.82122.6
16.620.919.7
14.720.217
14.317.816.1
1317.38.3
Accidents de transport
Suicides
Chutes accidentelles
mortalit >65 ans
Total hommesTotal femmesprel pmh
Irlande64704395
Danemark62304308
Belgique61353677
Pay-Bas60523787
Finlande59333689
Portugal58444006
Luxembourg57473436
Royaume-Uni57103869
Allemagne56013640
Autriche55203646
Espagne52113225
Sude51563403
Grce51523957
Italie51523166
France50122938
UE54333469
0.7683628078
AVC hommesAVC femmes
Portugal11741022
Grce850921
Luxembourg628520
Autriche613523
Italie590466
Finlande563479
Irlande534490
Allemagne525434
Danemark521427
Sude520428
Belgique510432
Royaume-Uni501470
Espagne492426
Pay-Bas477415
France355268
UE530444
0.9667420745
Morts violentes hommesMorts violentesfemmes
Finlande257116
France248151
Danemark240162
Luxembourg228128
Grce18490
Belgique183100
Autriche18283
Sude16483
Portugal15769
Italie15397
Allemagne13176
Espagne11752
Pay-Bas11683
Irlande10385
Royaume-Uni8460
UE15390
0.8444659798
Chutes accidentellesSuicidesAccidents transports
HommesFemmesHommesFemmesHommesFemmes
France42325916239
UE46393410229
Chutes accidentellesSuicidesAccidents de transport
Danemark1494124
Finlande1283728
Italie742430
Autriche686923
Belgique645429
Luxembourg545132
Irlande481117
Allemagne434316
France425923
Royaume-Uni391210
Sude313516
Pay-Bas262019
Portugal212733
Espagne183230
Grce17946
UE463422
mortalit >65 ans
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
AVC hommes
AVC femmes
pour 100 000 hab
AVC
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Morts violentes hommes
Morts violentesfemmes
pour 100 000 hab
AVC3
00
00
00
00
00
00
France
UE
pour 100 000 hab
accid
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Chutes accidentelles
Suicides
Accidents de transport
pour 100 000 hab
accid2
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Total hommes
Total femmes
pour 100 000 hab
accid3
1990
SexeTotal
Nombre de dcs par causes violentes
Graph4
113821032612278
113641179212420
102901239012012
105161156511282
93681179110447
8319117049672
81621063810095
7548106365316
Accidents de transport
Suicides
Chutes accidentelles
mortalit >65 ans
Total hommesTotal femmesprel pmh
Irlande64704395
Danemark62304308
Belgique61353677
Pay-Bas60523787
Finlande59333689
Portugal58444006
Luxembourg57473436
Royaume-Uni57103869
Allemagne56013640
Autriche55203646
Espagne52113225
Sude51563403
Grce51523957
Italie51523166
France50122938
UE54333469
0.7683628078
AVC hommesAVC femmes
Portugal11741022
Grce850921
Luxembourg628520
Autriche613523
Italie590466
Finlande563479
Irlande534490
Allemagne525434
Danemark521427
Sude520428
Belgique510432
Royaume-Uni501470
Espagne492426
Pay-Bas477415
France355268
UE530444
0.9667420745
Morts violentes hommesMorts violentesfemmes
Finlande257116
France248151
Danemark240162
Luxembourg228128
Grce18490
Belgique183100
Autriche18283
Sude16483
Portugal15769
Italie15397
Allemagne13176
Espagne11752
Pay-Bas11683
Irlande10385
Royaume-Uni8460
UE15390
0.8444659798
Chutes accidentellesSuicidesAccidents transports
HommesFemmesHommesFemmesHommesFemmes
France42325916239
UE46393410229
Chutes accidentellesSuicidesAccidents de transport
Danemark1494124
Finlande1283728
Italie742430
Autriche686923
Belgique645429
Luxembourg545132
Irlande481117
Allemagne434316
France425923
Royaume-Uni391210
Sude313516
Pay-Bas262019
Portugal212733
Espagne183230
Grce17946
UE463422
mortalit >65 ans
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
AVC hommes
AVC femmes
pour 100 000 hab
AVC
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Morts violentes hommes
Morts violentesfemmes
pour 100 000 hab
AVC3
00
00
00
00
00
00
France
UE
pour 100 000 hab
accid
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Chutes accidentelles
Suicides
Accidents de transport
pour 100 000 hab
accid2
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Total hommes
Total femmes
pour 100 000 hab
accid3
1990
SexeTotal
Nombre de dcs par AVP
Graph1
592393404378
568364331323
603449349370
576413369346
612517468421
631549441449
661570529569
634556503444
601513486410
666511502433
572431395406
526466440441
2002 (7242)
2003 (5732)
2004 (5217)
2005 (4990)
Feuil1
janvierfvriermarsavrilmaijuinjuilletaoutseptembreoctobrenovembredcembre
2002 (7242)5925686035766126316616346016665725267242
2003 (5732)3933644494135175495705565135114314665732
2004 (5217)4043313493694684415295034865023954405217
2005 (4990)3783233703464214495694444104334064414990
Feuil1
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
0000
2002 (7242)
2003 (5732)
2004 (5217)
2005 (4990)
Feuil2
Feuil3
Evolution du taux de mortalit standardis par AVC en France (p 100 000 hab)
Graph1
155.114.9
14113.6
124.412
98.29.8
888.8
77.57.8
66.67.1
56.66
Tous ges
65 ans
Total hommesTotal femmesprel pmh
Irlande64704395
Danemark62304308
Belgique61353677
Pay-Bas60523787
Finlande59333689
Portugal58444006
Luxembourg57473436
Royaume-Uni57103869
Allemagne56013640
Autriche55203646
Espagne52113225
Sude51563403
Grce51523957
Italie51523166
France50122938
UE54333469
0.7683628078
AVC hommesAVC femmes
Portugal11741022
Grce850921
Luxembourg628520
Autriche613523
Italie590466
Finlande563479
Irlande534490
Allemagne525434
Danemark521427
Sude520428
Belgique510432
Royaume-Uni501470
Espagne492426
Pay-Bas477415
France355268
UE530444
0.9667420745
Morts violentes hommesMorts violentesfemmes
Finlande257116
France248151
Danemark240162
Luxembourg228128
Grce18490
Belgique183100
Autriche18283
Sude16483
Portugal15769
Italie15397
Allemagne13176
Espagne11752
Pay-Bas11683
Irlande10385
Royaume-Uni8460
UE15390
0.8444659798
Chutes accidentellesSuicidesAccidents transports
HommesFemmesHommesFemmesHommesFemmes
France42325916239
UE46393410229
Chutes accidentellesSuicidesAccidents de transport
Danemark1494124
Finlande1283728
Italie742430
Autriche686923
Belgique645429
Luxembourg545132
Irlande481117
Allemagne434316
France425923
Royaume-Uni391210
Sude313516
Pay-Bas262019
Portugal212733
Espagne183230
Grce17946
UE463422
mortalit >65 ans
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
AVC hommes
AVC femmes
pour 100 000 hab
AVC
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Morts violentes hommes
Morts violentesfemmes
pour 100 000 hab
AVC2
00
00
00
00
00
00
France
UE
pour 100 000 hab
AVC3
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Chutes accidentelles
Suicides
Accidents de transport
pour 100 000 hab
accid
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Total hommes
Total femmes
pour 100 000 hab
accid2
1990
SexeTotal
Nombre de dcs par AVC en France par classe dge (0-74 ans)
Graph2
84536505757
86835776200
79933166332
85832816630
79530996612
74630636844
77228916773
70029576328
67927426013
72927625723
60324965416
58724965106
56324854965
0-44
45-64
65-74
mortalit >65 ans
Total hommesTotal femmesprel pmh
Irlande64704395
Danemark62304308
Belgique61353677
Pay-Bas60523787
Finlande59333689
Portugal58444006
Luxembourg57473436
Royaume-Uni57103869
Allemagne56013640
Autriche55203646
Espagne52113225
Sude51563403
Grce51523957
Italie51523166
France50122938
UE54333469
0.7683628078
AVC hommesAVC femmes
Portugal11741022
Grce850921
Luxembourg628520
Autriche613523
Italie590466
Finlande563479
Irlande534490
Allemagne525434
Danemark521427
Sude520428
Belgique510432
Royaume-Uni501470
Espagne492426
Pay-Bas477415
France355268
UE530444
0.9667420745
Morts violentes hommesMorts violentesfemmes
Finlande257116
France248151
Danemark240162
Luxembourg228128
Grce18490
Belgique183100
Autriche18283
Sude16483
Portugal15769
Italie15397
Allemagne13176
Espagne11752
Pay-Bas11683
Irlande10385
Royaume-Uni8460
UE15390
0.8444659798
Chutes accidentellesSuicidesAccidents transports
HommesFemmesHommesFemmesHommesFemmes
France42325916239
UE46393410229
Chutes accidentellesSuicidesAccidents de transport
Danemark1494124
Finlande1283728
Italie742430
Autriche686923
Belgique645429
Luxembourg545132
Irlande481117
Allemagne434316
France425923
Royaume-Uni391210
Sude313516
Pay-Bas262019
Portugal212733
Espagne183230
Grce17946
UE463422
mortalit >65 ans
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
AVC hommes
AVC femmes
pour 100 000 hab
AVC
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Morts violentes hommes
Morts violentesfemmes
pour 100 000 hab
AVC3
00
00
00
00
00
00
France
UE
pour 100 000 hab
accid
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Chutes accidentelles
Suicides
Accidents de transport
pour 100 000 hab
accid2
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Total hommes
Total femmes
pour 100 000 hab
accid3
1990
SexeTotal
Donneurs dcdsLa France/ autres pays
Evolution des taux bruts de donneurs prlevs pmh
Taux bruts de donneurs prlevs en 2004QUID?
Taux bruts de donneurs prlves en 2004 (mort encphalique cur arrt)
Graph1
34.60648148151.6435185185
24.07407407410
22.56097560980.3658536585
22.20
21.82692307690.4807692308
21.14235500880
20.99186991870
20.48543689320.1941747573
160
15.15337423316.8098159509
14.71204188480
13.77966101691.4745762712
13.04611650490
60
0.47619047620
Mort Enc
Cur arrt
pmh
Feuil1
AutricheBelgiqueRep tchqueFranceAllemagneGrceHongrieItaliePolognePortugalRoumanieEspagnePays-BasGrande BretagneUSA
8.210.410.361.582.4111056.938.2102143.216.359297
Cadaveric185227211129110756616012035622221014952478137150
nhbd3527111187
taux ME22.621.820.521.013.06.016.021.114.722.20.534.615.213.824.1
taux cadaveric22.922.320.721.013.06.016.021.114.722.20.536.322.015.324.1
taux nhbd0.40.50.20.00.00.00.00.00.00.00.01.66.81.50.0
kidney
cadaveric348353404225919891162841746104539219206442314429534
living38193816448976111352229168612504636647
nhbd137292171147
total kidney39937944424232478192295188110674211872217844205216181
%DV9.55.08.66.819.739.63.77.22.16.989.82.829.622.641.1
%NHBD3.31.80.50.00.00.00.00.00.00.00.04.120.37.20.0
taux greffe cadaveric42.433.939.236.724.110.528.430.727.439.20.947.826.024.432.1
taux greffe living4.61.83.72.75.96.91.12.40.62.98.01.415.37.822.4
taux greffe nhbd1.60.70.20.00.00.00.00.00.00.00.02.110.52.50.0
taux greffe total48.736.443.139.430.117.529.533.127.942.18.951.351.834.854.5
liver
cadaveric13222983931881294310351992051610401097316168
living625148719185918310323
nhbd55828
total foie13825984979888294310542172102510631207696491
%DV4.39.71.24.90.80.00.01.88.32.436.01.72.51.35.0
%NHBD0.01.90.00.00.00.00.00.00.00.00.00.56.73.60.0
taux greffe total16.824.98.215.910.82.64.318.55.721.01.224.67.413.021.9
heart h-lung64774833941261035334454294321802055
heart-lung1322143171539
lung78637167240485110143541341173
pancreas4142251031921294161227437791484
kp30181786163125515122612169880
pancreas5581720391121610604
rein
nvx inscrits4024524403032283337126041190432832280827298
patients 31/128059366085626927084710216561120116264231116529961924
120713881048865812103847139291652391020584231948810789222
cadaveric3.53.92.63.86.17.34.95.22.30.0108.32.02.25.69.4
tous donneurs3.03.72.43.64.94.44.74.92.20.011.01.91.14.05.5
Foie
nvx inscrits1833089311601427811359290234146015487510180
patients 31/1210824346474152547145710529070115525317336
291551139163429520128281639505242161309112827516
2.22.41.71.83.40.03.02.72.00.032.82.12.81.54.5
2.12.11.71.73.30.03.02.71.80.021.02.02.61.54.2
Cur
nvx inscrits95937542975692149821335394592062908
patients 31/12753474277613182264017872113451113309
17012714970613692743113839101075071043176217
H and L
nvx inscrits2918
patients 31/123914
Lung
nvx inscrits10066161764059186738882051964
patients 31/125746221444574238831862723659
157112383208620134241500691744775623
Feuil2
AutricheBelgiqueRep TchqueFranceAllemagneGrceHongrieItaliePolognePortugalRoumanieEspagnePays-BasGrande BretagneUSA
taux ME22.621.820.521.013.06.016.021.114.722.20.534.615.213.824.1
taux cur arrt0.40.50.20.00.00.00.00.00.00.00.01.66.81.50.0
Mort EncCur arrt
Espagne34.61.6
USA24.10.0
Autriche22.60.4
Portugal22.20.0
Belgique21.80.5
Italie21.10.0
France21.00.0
Rep Tchque20.50.2
Hongrie16.00.0
Pays-Bas15.26.8
Pologne14.70.0
Grande Bretagne13.81.5
Allemagne13.00.0
Grce6.00.0
Roumanie0.50.0
Feuil2
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Mort Enc
Cur arrt
Feuil3
AutricheBelgiqueRep tchqueFranceAllemagneGrceHongrieItaliePolognePortugalRoumanieEspagnePays-BasGrande BretagneUSA
cadaveric3.53.92.63.86.17.34.95.22.30.02.02.25.69.4
tous donneurs3.03.72.43.64.94.44.74.92.20.02.01.14.05.5
Mort enchaliquetous donneurs
Espagne2.02.0
Pays-Bas2.21.1
Pologne2.32.2
Rep tchque2.62.4
Autriche3.53.0
France3.83.6
Belgique3.93.7
Hongrie4.94.7
Italie5.24.9
Grande Bretagne5.64.0
Allemagne6.14.9
Grce7.34.4
USA9.45.5
cadaverictous donneurs
Grande Bretagne1.51.5
Rep tchque1.71.7
France1.81.7
Pologne2.01.8
Espagne2.12.0
Autriche2.22.1
Belgique2.42.1
Italie2.72.7
Pays-Bas2.82.6
Hongrie3.03.0
Allemagne3.43.3
USA4.54.2
Feuil3
00
00
00
00
00
00
00
00
00
00
00
00
00
Mort enchalique
tous donneurs
Feuil4
00
00
00
00
00
00
00
00
00
00
00
00
cadaveric
tous donneurs
Mort encphaliqueCur arrtDonneur vivantRsidu Opratoire
ReinXXX
FoieXXX
CurXX
Cur PoumonX
PoumonXXX
PancrasXX
IntestinX
CorneXX
PeauXXXX
VaisseauxXXXX
Valves cardiaquesXX
Os massifsXX
Ttes fmoralesXXXX
Tissus compositesX
CSHAuto, App, Non app, Plac
Taux de mortalit standardis par pays europens (AVC, Accidents, AVP) p 100 000 habEurostat 2000
Graph1
145
137.6
136.5
110.8
103.4
67.7
63.6
59.8
58.5
57.1
56.1
39
50
43.1
42.1
36.5
28.4
26.8
25.9
25.5
22.7
19.6
17.8
16.2
17.8
14.9
14.3
14.1
13
12.6
12.1
11
9.3
6.9
5.6
1.9
Feuil1
AutricheBelgiqueRep tchqueFranceAllemagneGrceHongrieItaliePolognePortugalRoumanieEspagnePays-BasGrande BretagneUSA
8.210.410.361.582.4111056.938.2102143.216.359297
Cadaveric185227211129110756616012035622221014952478137150
nhbd3527111187
taux ME22.621.820.521.013.06.016.021.114.722.20.534.615.213.824.1
taux cadaveric22.922.320.721.013.06.016.021.114.722.20.536.322.015.324.1
taux nhbd0.40.50.20.00.00.00.00.00.00.00.01.66.81.50.0
kidney
cadaveric348353404225919891162841746104539219206442314429534
living38193816448976111352229168612504636647
nhbd137292171147
total kidney39937944424232478192295188110674211872217844205216181
%DV9.55.08.66.819.739.63.77.22.16.989.82.829.622.641.1
%NHBD3.31.80.50.00.00.00.00.00.00.00.04.120.37.20.0
taux greffe cadaveric42.433.939.236.724.110.528.430.727.439.20.947.826.024.432.1
taux greffe living4.61.83.72.75.96.91.12.40.62.98.01.415.37.822.4
taux greffe nhbd1.60.70.20.00.00.00.00.00.00.00.02.110.52.50.0
taux greffe total48.736.443.139.430.117.529.533.127.942.18.951.351.834.854.5
liver
cadaveric13222983931881294310351992051610401097316168
living625148719185918310323
nhbd55828
total foie13825984979888294310542172102510631207696491
%DV4.39.71.24.90.80.00.01.88.32.436.01.72.51.35.0
%NHBD0.01.90.00.00.00.00.00.00.00.00.00.56.73.60.0
taux greffe cadaveric16.122.08.115.110.72.64.318.25.220.50.824.16.712.420.8
taux greffe living0.72.40.10.80.10.00.00.30.50.50.40.40.20.21.1
taux greffe nhbd0.00.50.00.00.00.00.00.00.00.00.00.10.50.50.0
taux greffe total16.824.98.215.910.82.64.318.55.721.01.224.67.413.021.9
heart h-lung64774833941261035334454294321802055
heart-lung1322143171539
lung78637167240485110143541341173
pancreas4142251031921294161227437791484
kp30181786163125515122612169880
pancreas5581720391121610604
rein
nvx inscrits4024524403032283337126041190432832280827298
patients 31/128059366085626927084710216561120116264231116529961924
120713881048865812103847139291652391020584231948810789222
cadaveric3.53.92.63.86.17.34.95.22.30.0108.32.02.25.69.4
tous donneurs3.03.72.43.64.94.44.74.92.20.011.01.91.14.05.5
Foie
nvx inscrits1833089311601427811359290234146015487510180
patients 31/1210824346474152547145710529070115525317336
291551139163429520128281639505242161309112827516
2.22.41.71.83.40.03.02.72.00.032.82.12.81.54.5
2.12.11.71.73.30.03.02.71.80.021.02.02.61.54.2
Cur
nvx inscrits95937542975692149821335394592062908
patients 31/12753474277613182264017872113451113309
17012714970613692743113839101075071043176217
0.90.60.70.51.30.40.30.90.70.010.70.30.40.40.9
H and L
nvx inscrits2918
patients 31/123914
Lung
nvx inscrits10066161764059186738882051964
patients 31/125746221444574238831862723659
157112383208620134241500691744775623
Feuil2
AutricheBelgiqueRep TchqueFranceAllemagneGrceHongrieItaliePolognePortugalRoumanieEspagnePays-BasGrande BretagneUSA
taux ME22.621.820.521.013.06.016.021.114.722.20.534.615.213.824.1
taux cur arrt0.40.50.20.00.00.00.00.00.00.00.01.66.81.50.0
Mort EncCur arrt
Roumanie0.50.0
Grce6.00.0
Allemagne13.00.0
Grande Bretagne13.81.5
Pologne14.70.0
Pays-Bas15.26.8
Hongrie16.00.0
Rep Tchque20.50.2
France21.00.0
Italie21.10.0
Belgique21.80.5
Portugal22.20.0
Autriche22.60.4
USA24.10.0
Espagne34.61.6
Cur battantDonneur vivantCur Arrttaux greffe total
Roumanie0.98.00.08.9
Grce10.56.90.017.5
Pologne27.40.60.027.9
Hongrie28.41.10.029.5
Allemagne24.15.90.030.1
Italie30.72.40.033.1
Grande Bretagne24.47.82.534.8
Belgique33.91.80.736.4
France36.72.70.039.4
Portugal39.22.90.042.1
Rep tchque39.23.70.243.1
Autriche42.44.61.648.7
Espagne47.81.42.151.3
Pays-Bas26.015.310.551.8
USA32.122.40.054.5
taux greffe cadaverictaux greffe livingtaux greffe total
Roumanie0.80.41.2
Grce2.60.02.6
Hongrie4.30.04.3
Pologne5.20.55.7
Pays-Bas6.70.27.4
Rep tchque8.10.18.2
Allemagne10.70.110.8
Grande Bretagne12.40.213.0
France15.10.815.9
Autriche16.10.716.8
Italie18.20.318.5
Portugal20.50.521.0
USA20.81.121.9
Espagne24.10.424.6
Belgique22.02.424.9
Feuil2
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Mort Enc
Cur arrt
Feuil3
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Cur battant
Donneur vivant
Cur Arrt
Feuil4
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
taux greffe cadaveric
taux greffe living
penurie rein
Mort encphaliqueTous donneurs
Espagne2.02.0
Pays-Bas2.21.1
Pologne2.32.2
Rep tchque2.62.4
Autriche3.53.0
France3.83.6
Belgique3.93.7
Hongrie4.94.7
Italie5.24.9
Grande Bretagne5.64.0
Allemagne6.14.9
Grce7.34.4
USA9.45.5
cadaverictous donneurs
Grande Bretagne1.51.5
Rep tchque1.71.7
France1.81.7
Pologne2.01.8
Espagne2.12.0
Autriche2.22.1
Belgique2.42.1
Italie2.72.7
Pays-Bas2.82.6
Hongrie3.03.0
Allemagne3.43.3
USA4.54.2
00
00
00
00
00
00
00
00
00
00
00
00
00
Mort encphalique
Tous donneurs
00
00
00
00
00
00
00
00
00
00
00
00
cadaveric
tous donneurs
Mort encphaliqueCur arrtDonneur vivantRsidu Opratoire
ReinXXX
FoieXXX
CurXX
Cur PoumonX
PoumonXXX
PancrasXX
IntestinX
CorneXX
PeauXXXX
VaisseauxXXXX
Valves cardiaquesXX
Os massifsXX
Ttes fmoralesXXXX
Tissus compositesX
CSHAuto, App, Non app, Plac
taux de moratlit standardis AVC
geo
Hongrie153.3145138.7135.6
Portugal146.6137.6130.7122.2
Rp Tchque136.2136.5132130.5
Grce109.3110.8116.2114.7
Pologne107.5103.410398.6
Autriche73.467.761.962.3
Italie65.863.660.559.1
Royaume-Uni66.359.8::
Allemagne63.458.556.355.1
Espagne6257.155.752
Pays-Bas5856.153.954.7
France41.73939.238
unitsdth_rtTaux de mortalit standardis
sextTotal
agetotTotal
icd59Accidents (V01-X59)
time1999a002000a002001a002002a00
geo
Hongrie57.25049.951.9
Rp Tchque4343.141.942.3
Pologne46.242.14040.2
France39.536.537.335.7
Autriche28.728.426.924.6
Espagne26.926.825.323.9
Italie26.925.926.526.1
Grce60.325.523.328.8
Portugal25.322.729.133.9
Allemagne19.319.619.419.1
Pays-Bas17.817.818.617.1
Royaume-Uni16.816.2::
unitsdth_rtTaux de mortalit standardis
sextTotal
agetotTotal
icd60Accidents de transport (V01-V99)
time1999a002000a002001a002002a00
geo
Pologne1917.815.716.1
Espagne14.814.913.913.1
Rp Tchque14.314.313.513.6
Hongrie15.114.114.116.1
Portugal15.71317.319.9
France13.412.613.112.4
Italie12.512.112.311.9
Autriche12.11110.911
Allemagne9.69.38.48.3
Pays-Bas7.16.96.26.3
Royaume-Uni5.85.6::
Grce221.91.615.5
AVCAccidentAccident de transport
HongriePortugalRp TchqueGrcePologneAutricheItalieRoyaume-UniAllemagneEspagnePays-BasFranceHongrieRp TchquePologneFranceAutricheEspagneItalieGrcePortugalAllemagnePays-BasRoyaume-UniPologneEspagneRp TchqueHongriePortugalFranceItalieAutricheAllemagnePays-BasRoyaume-UniGrce
145137.6136.5110.8103.467.763.659.858.557.156.1395043.142.136.528.426.825.925.522.719.617.816.217.814.914.314.11312.612.1119.36.95.61.9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
Taux de mortalit standardiss des 65 ans et plus
Graph1
64704395
62304308
61353677
60523787
59333689
58444006
57473436
57103869
56013640
55203646
52113225
51563403
51523957
51523166
50122938
54333469
Total hommes
Total femmes
pour 100 000 hab
mortalit >65 ans
Total hommesTotal femmesprel pmh
Irlande64704395
Danemark62304308
Belgique61353677
Pay-Bas60523787
Finlande59333689
Portugal58444006
Luxembourg57473436
Royaume-Uni57103869
Allemagne56013640
Autriche55203646
Espagne52113225
Sude51563403
Grce51523957
Italie51523166
France50122938
UE54333469
0.7683628078
AVC hommesAVC femmes
Portugal11741022
Grce850921
Luxembourg628520
Autriche613523
Italie590466
Finlande563479
Irlande534490
Allemagne525434
Danemark521427
Sude520428
Belgique510432
Royaume-Uni501470
Espagne492426
Pay-Bas477415
France355268
UE530444
0.9667420745
Morts violentes hommesMorts violentesfemmes
Finlande257116
France248151
Danemark240162
Luxembourg228128
Grce18490
Belgique183100
Autriche18283
Sude16483
Portugal15769
Italie15397
Allemagne13176
Espagne11752
Pay-Bas11683
Irlande10385
Royaume-Uni8460
UE15390
0.8444659798
Chutes accidentellesSuicidesAccidents transports
HommesFemmesHommesFemmesHommesFemmes
France42325916239
UE46393410229
Chutes accidentellesSuicidesAccidents de transport
Danemark1494124
Finlande1283728
Italie742430
Autriche686923
Belgique645429
Luxembourg545132
Irlande481117
Allemagne434316
France425923
Royaume-Uni391210
Sude313516
Pay-Bas262019
Portugal212733
Espagne183230
Grce17946
UE463422
mortalit >65 ans
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
AVC hommes
AVC femmes
pour 100 000 hab
AVC
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Morts violentes hommes
Morts violentesfemmes
pour 100 000 hab
AVC3
00
00
00
00
00
00
France
UE
pour 100 000 hab
accid
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Chutes accidentelles
Suicides
Accidents de transport
pour 100 000 hab
accid2
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Total hommes
Total femmes
pour 100 000 hab
accid3
1990
SexeTotal
Taux de mortalit standardiss par AVC des 65 ans et plus
Graph1
11741022
850921
628520
613523
590466
563479
534490
525434
521427
520428
510432
501470
492426
477415
355268
530444
AVC hommes
AVC femmes
pour 100 000 hab
mortalit >65 ans
Total hommesTotal femmesprel pmh
Irlande64704395
Danemark62304308
Belgique61353677
Pay-Bas60523787
Finlande59333689
Portugal58444006
Luxembourg57473436
Royaume-Uni57103869
Allemagne56013640
Autriche55203646
Espagne52113225
Sude51563403
Grce51523957
Italie51523166
France50122938
UE54333469
0.7683628078
AVC hommesAVC femmes
Portugal11741022
Grce850921
Luxembourg628520
Autriche613523
Italie590466
Finlande563479
Irlande534490
Allemagne525434
Danemark521427
Sude520428
Belgique510432
Royaume-Uni501470
Espagne492426
Pay-Bas477415
France355268
UE530444
0.9667420745
Morts violentes hommesMorts violentesfemmes
Finlande257116
France248151
Danemark240162
Luxembourg228128
Grce18490
Belgique183100
Autriche18283
Sude16483
Portugal15769
Italie15397
Allemagne13176
Espagne11752
Pay-Bas11683
Irlande10385
Royaume-Uni8460
UE15390
0.8444659798
Chutes accidentellesSuicidesAccidents transports
HommesFemmesHommesFemmesHommesFemmes
France42325916239
UE46393410229
Chutes accidentellesSuicidesAccidents de transport
Danemark1494124
Finlande1283728
Italie742430
Autriche686923
Belgique645429
Luxembourg545132
Irlande481117
Allemagne434316
France425923
Royaume-Uni391210
Sude313516
Pay-Bas262019
Portugal212733
Espagne183230
Grce17946
UE463422
mortalit >65 ans
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
AVC hommes
AVC femmes
pour 100 000 hab
AVC
257116
248151
240162
228128
18490
183100
18283
16483
15769
15397
13176
11752
11683
10385
8460
15390
Morts violentes hommes
Morts violentesfemmes
pour 100 000 hab
AVC2
4246
3239
5934
1610
2322
99
France
UE
pour 100 000 hab
AVC3
1494124
1283728
742430
686923
645429
545132
481117
434316
425923
391210
313516
262019
212733
183230
17946
463422
Chutes accidentelles
Suicides
Accidents de transport
pour 100 000 hab
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Total hommes
Total femmes
pour 100 000 hab
1990
SexeTotal
Taux de mortalit standardiss par causes violentes des 65 ans et plus
Graph2
257116
248151
240162
228128
18490
183100
18283
16483
15769
15397
13176
11752
11683
10385
8460
15390
Morts violentes hommes
Morts violentesfemmes
pour 100 000 hab
mortalit >65 ans
Total hommesTotal femmesprel pmh
Irlande64704395
Danemark62304308
Belgique61353677
Pay-Bas60523787
Finlande59333689
Portugal58444006
Luxembourg57473436
Royaume-Uni57103869
Allemagne56013640
Autriche55203646
Espagne52113225
Sude51563403
Grce51523957
Italie51523166
France50122938
UE54333469
0.7683628078
AVC hommesAVC femmes
Portugal11741022
Grce850921
Luxembourg628520
Autriche613523
Italie590466
Finlande563479
Irlande534490
Allemagne525434
Danemark521427
Sude520428
Belgique510432
Royaume-Uni501470
Espagne492426
Pay-Bas477415
France355268
UE530444
0.9667420745
Morts violentes hommesMorts violentesfemmes
Finlande257116
France248151
Danemark240162
Luxembourg228128
Grce18490
Belgique183100
Autriche18283
Sude16483
Portugal15769
Italie15397
Allemagne13176
Espagne11752
Pay-Bas11683
Irlande10385
Royaume-Uni8460
UE15390
0.8444659798
Chutes accidentellesSuicidesAccidents transports
HommesFemmesHommesFemmesHommesFemmes
France42325916239
UE46393410229
Chutes accidentellesSuicidesAccidents de transport
Danemark1494124
Finlande1283728
Italie742430
Autriche686923
Belgique645429
Luxembourg545132
Irlande481117
Allemagne434316
France425923
Royaume-Uni391210
Sude313516
Pay-Bas262019
Portugal212733
Espagne183230
Grce17946
UE463422
mortalit >65 ans
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
AVC hommes
AVC femmes
pour 100 000 hab
AVC
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Morts violentes hommes
Morts violentesfemmes
pour 100 000 hab
AVC3
00
00
00
00
00
00
France
UE
pour 100 000 hab
accid
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
000
Chutes accidentelles
Suicides
Accidents de transport
pour 100 000 hab
accid2
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
00
Total hommes
Total femmes
pour 100 000 hab
accid3
1990
SexeTotal
Potentiels de donneursDonneurs cur battant (A partir des taux pmh dtudes exhaustives, avec ou sans prise en compte des contre-indications : 55-62 pmhEstimation France 3300< donneurs60 ans ou causes de dcs moins classiques
Donneurs vivants Rein 2005 : faible % par rapport aux Pays nordiques USA (50%)
Donneur vivant
Evolution de la greffe de rein partir de donneur vivant
Activit de transplantation rnale et proportion de donneurs vivants en Europe en 2004
Evolution de la nationalit des greffs partir dun donneur vivant
Evolution des liens entre le donneur et le receveur dun rein de donneur vivant
Graph1
28375300
37344200
37413300
43504400
414714600
505324900
606928511
688139440
ASC
COLL
CONJ
DESC
VIEC
ONCL
age nvx inscrit rein
Nombre de nouveaux inscrits en greffe rnale
classeaninscTotal
1996199719981999200020012002200320042005
0-15 ans968785961008677759081873
16-45 ans121011611133120110931133116711381283122611745
46-60 ans805846831955890101510671008121712669900
61 ans et +1721972142662543073583834605743185
Total228322912263251823372541266926043050314725703
donneur vivant nationalit
nombre de greffe de donneur vivant
NATIONALangrfTotal
19981999200020012002200320042005
ALB100000001
B000000101
BUL000000011
CAPV000100001
CLB000000011
CORN000001001
DJIB000001001
EQU010000001
G000100001
GB000001001
GHA000000011
GUINBI000000011
GUINEQ000000101
I001000001
IR000000101
MALI000000101
MAURICE000000011
MAURIT000010001
NI000000011
PER001000001
USA000000011
A000100102
CA100010002
E000100012
EG001001002
GA000001012
KOW000020002
PAK010001002
SER001010002
SRI000002002
??000200013
MG001001103
RO000101013
TQ000010113
YOUG000002013
P011001115
S100200025
TU102000126
MA1213124216
42132281638dans les 38, 1 pays de rsidence AL et 37 F
AL137714819766
F6367677985111124153749
Total737784101108136164196939
19981999200020012002200320042005
Franais86.387.079.878.278.781.675.678.1
Etrangers13.713.020.221.821.318.424.421.9
19981999200020012002200320042005
% doneurc vivants3.94.24.45.04.86.46.87.7
18821842192420222253212724232562
lien donneur vivant vs receveur
nombre de greffe de donneur vivant
angrfTotal
ASC2837374341506068364
COLL3734415047536981412
CONJ543414242839121
DESC3234695436
ONCL000000101
VIEC000000145
Total737784101108136164196939
19981999200020012002200320042005
ASC2837374341506068
COLL3734415047536981
CONJ543414242839
DESC32346954
ONCL00000010
VIEC00000014
lien donneur vivant vs receveur
000000
000000
000000
000000
000000
000000
000000
000000
ASC
COLL
CONJ
DESC
VIEC
ONCL
Evolution de la greffe de foie partir de donneur vivant
La greffe
Evolution du nombre de greffes d'organes en France tous types confondus
Evolution du nombre de patients inscrits sur la liste d'attente de greffe d'organes au 31 dcembre de chaque anne
La greffe de cur
Evolution de lactivit de greffe de cur
La demande de greffon et loffre de greffe Cur
Nombre de nouveaux inscrits en liste dattente de greffe de cur selon lindication 2004
Survie du receveur aprs greffe de cur
Survie du receveur aprs greffe de cur selon la priode de greffe
Survie du receveur aprs greffe de cur selon son ge
Survie globale du receveur aprs une retransplantation cardiaque
Greffe de cur en 2004 : Autres pays
Efficience : % de greffe de cur/nombre de PMO
La greffe de poumon cur-poumons
Evolution de lactivit de greffe de poumons et de cur-poumons depuis 1990
La demande de greffon et loffre de greffe Poumon/Cur-Poumons
Nombre de nouveaux inscrits en liste dattente pour greffe de Px et C-PX selon lindication 2004
Survie du receveur aprs greffe de poumons selon la priode de greffe
Survie du receveur selon le type de greffe
Graph3
111
0.964180.982940.95737
0.918840.959810.92791
0.918840.954030.9095
0.918840.950170.90582
0.915820.946320.89477
0.909770.944390.88741
0.903730.936680.88005
0.903730.93090.87636
0.894660.928970.87268
0.894660.927050.86532
0.894660.925120.86532
0.891640.923190.86163
0.882570.915480.85059
0.876530.913550.83954
0.87350.913550.83218
0.864440.903920.83218
0.864440.896210.82113
0.855370.890430.81745
0.84630.882720.81745
0.84630.876940.79904
0.84630.875010.79167
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0.843280.861520.78431
0.840260.857660.77694
0.837230.857660.77694
0.834210.853810.77694
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0.834210.84610.76958
0.831190.844170.7659
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0.803990.826820.7438
0.803990.822970.73644
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0.782830.795990.70698
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0.773760.78250.69225
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0.773760.780570.68857
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0.773760.778640.68857
0.773760.778640.68857
0.773760.776710.68121
0.770740.776710.68121
0.767720.770930.68121
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0.761670.7690.68121
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0.740510.74780.65909
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0.734470.74780.65909
0.734470.740090.65909
0.734470.738170.65909
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0.731450.734310.65909
0.731450.734310.65909
0.728420.734310.65909
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0.728420.732390.65909
0.728420.730460.65539
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0.72540.730460.65539
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0.710290.72660.65169
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0.695180.718890.63317
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0.574150.626290.5431
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0.574150.624180.53925
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0.568080.619970.53925
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0.565040.615690.53925
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0.565040.613550.53925
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0.565040.609280.53925
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