RegistationWelcome IntroductionSESSION 1: Early events in ventral midbrain fate specification | Sandra BlaessJuha Partanen - Development of brainstem neurons associated with dopaminergic nucleiClaude Brodski - BMP/SMAD Pathway Promotes Neurogenesis of Midbrian Dopaminergic Neurons In Vivo and in Human Induced Pluripotent and Neural Stem CellsRefreshmentsAndrea Wizenmann - Different uses for PITX3 in chick and mouse dopaminergic precursor developmentTae Wan Kim - Derivation of Enriched Engraftable Midbrain Dopamine Neurons from Human Pluripotent Stem Cells in a cGMP-qualified Condition for the Cell Replacement Therapy to Parkinson PatientsGerard W. O’Keeffe - BMP/SMAD Pathway Promotes Axonal Growth Of Developing Dopaminergic NeuronsSandra Blaess - Molecular mechanisms underlying the diversification and migration of midbrain dopaminergic neuronsLunchPoster Flash TalksSESSION 2: Dopamine circuits and axon guidance | Martin LévesqueLouis-Eric Trudeau - Towards a better understanding of the development of the neurochemically complex exonal arborization of dopamine neuronsCecilia Flores - Making dopamine connections in adolescenceMary Hynes - Title TBCRefreshments Jeroen Pasterkamp - Novel mouse genetics tools for dissecting dopamine neuron developmentTiago Cardoso - hESC-derived dopaminergic transplants integrate into basal ganglia circuitry in a preclinical model of Parkinson´s diseaseAsa Mackenzie - Disentangeling subtypes of midbrain dopamine in neurocircuitry and reward-related behaviorMartin Lévesque - Axon guidance of midbrain dopamine neuronsDrinks ReceptionDinner & Social

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SESSION 3: Dopamine neuron diversity | Rajeshwar AwatramaniSiew-Lan Ang - LIM only proteins regulate the survival of a subset of midbrain dopaminergic neuronsWolfgang Driever - Functional and molecular subtype diversity in the zebrafish diencephalospinal dopaminergic systemMarten Smidt - Genetic and epigenetic programming of dopaminergic subsetsThomas Perlmann - Interrogating dopamine neurogenesis, diversity and clinical utility using single cell approachesRefreshmentsAlain Prochiantz - Title TBCRajeshwar Awatramani - Molecular genetic approaches to uncover DA neuron diversityHuaibin Cai - Title TBCLunchPostersLia Panman - Directed differentiation of a substantia nigra dopaminergic neurons from mouse and human pluripotent stem cellsJens Schwamborn - Modeling Parkinson’s disease in vitro with 3D cultures and organoidsVania Broccoli - Novel in vitro human models of functional and diseased neuronal circuitsRefreshmentsNilima Prakash - WNT/b-catenin dosage-dependent differentiation of midbrain dopaminergic neuron subsets.Su-Chun Zhang - Reconstruction of the Nigra-Striatal Circuit by Human Dopamine Neurons Lorenz Studer - Dopaminergic differentiation of human pluripotent stem cells - from Development to Cell TherapyDrinks ReceptionGala Dinner

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SESSION 5: Cell replacement strategies for Parkinson’s disease | Emmanouil MetzakopianAnders Bjorklund - Dopamine neuron replacement in Parkinson’s disease: 30 years in perspectiveWolfgang Wurst - Modelling Prodromal Phase of Parkinson’sAxion BioSystems - Modeling neurodegenerative diseases in-a-dish: Exploring life’s circuitry with next generation MEA| Giovanna De FilippiAlessandra Zanon - Establishment of a 3D culture system for the generation of dopaminergic neurons for disease modeling in PDJanelle Drouin-Ouellet - Direct reprogramming of patient skin fibroblasts to induced dopaminergic neurons to model idiopathic Parkinson's diseaseRefreshmentsErnest Arenas - From dopaminergic neuron development to cell replacement strategies for Parkinson’s diseaseEmmanouil Metzakopian - Defining human iPSC derived dopamine neurons via single cell RNA-SeqJeff Kordower - Dopaminergic cell replacement for Parkinson’sClosing remarksLunchDeparture

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MAY 13

MAY 14

MAY 15

Development of the Dopaminergic System - from Stem Cells to Circuits13-15 May 2019 - Fodele Beach Resort, Crete

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