Electronics Laboratory Director: Prof Costas Balas
Electronic and Computer Architecture Division
Dept. of Electronic & Computer Engineering
Technical University of Crete
GR 73100 Chania, Crete, Greece
www.electronics.tuc.gr
Activity Profile
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Electronics lab
People & Structure
RF-IC design 2003-
Optoelectronics 2002-
Total
Faculty Matthias Bucher Assistant Professor Group leader
Costas Balas Associate Professor Lab director Group leader
2
Post Doctoral Researchers
Dr. Rupendra Sharma (Sept. 2011 – Nov. 2012, FP7 COMON)
1
PhD Students 1.A. Antonopoulos, 2.G. Rozakis, 3.N. Mavredakis 4.M.-A. Chalkiadaki 5.N. Makris
1. G. Papoutsoglou 2. A. Tsapras 7
MSc Students 1.K. Kostopoulos 2.K.Papathanasiou 3.G. Gyroukis
1.V. Kavvadias 2.G. Epitropou 3.D. Iliou 4.C. Katsikani
7
Total 17
2
Diploma Theses
12 10 22
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Teaching
Under Graduate Courses
ACE 301: Electronics I (CB, Comp)
ACE 311: Electronics II (MB, Comp)
ACE 414: Optoelectronics (CB, Choice)
ACE 506: Design of CMOS Analog Integrated Circuits (MB, Choice)
ACE 413: Biomedical Engineering (CB)
Post Graduate Courses ACE 604: Special Themes of Analog IC
Design (MB) ACE 614: Optoelectronics (Cross-linked
with ΗΡΥ 414) (CB) ACE 634: Electronic Imaging (CB)
Exams: theory, labs, projects.
Target is to develop a solid theoretical background including both semiconductor physics and circuits
combined with… hands on practice …. for developing, team working and practical problem-solving skills
Digital Notes Created: CB : ACE 301 theory, pages: 150, Labs pages: 40, ACE 414 theory, pages 130, labs MB: ACE 311 theory, pages: 300, Labs pages: 70, ACE 416 theory, pages 120
Students assembling /testing a diode laser driver (ACE 414)
3
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Invited lectures @ GR student IEEE student branch, Patras 2011 (C.B)
Summer School -EU Eng. Student Association “BEST” (org/hosted by C.B. @ Chania 2011)
M. Bucher (Tutorial), “CMOS Device Modeling for Analog/RF Design”, European Solid-State Circuits Conference (ESSCIRC), Athens, Sept. 2009
National/International
seminars (2010-2011)
National/International
book chapters for graduate ed.
C. Balas, G. Epitropou, C. Pappas: “Multi/Hyper-Spectral Imaging” in Handbook of Biomedical Optics, Taylor&Francis Books, Inc, USA, 2011.
C. Balas and E. Diakomanolis, “New technologies in Colposcopy” in Colposcopy text book, Paschalides Ed. Greece, 2010.
C. Balas et al. “Dynamic Spectral Imaging for the Detection of Cervical Neoplasia” in Cervical Cancer Prevention text book, Studio Press, 2007.
M. Bucher et al., “EKV3.0: An Advanced Charge Based MOS Transistor Model”, in Transistor Level Modeling for Analog/RF IC Design, Springer, 2006.
4
RF Integrated Circuit Design Group
Electronics Laboratory
Dept. of Electronic & Computer Engineering
Technical University of Crete GR 73100 Chania, Crete, Greece
Matthias Bucher Assistant Professor, Electronics Laboratory
+30 28210 37210 Bucher “at” electronics.tuc.gr
www.electronics.tuc.gr, www.ekv3.tuc.gr
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
International Technology Roadmap for Semiconductors (ITRS) recognizes COMPACT MODELLING as one of the bottlenecks in the
deployment of new technologies
“Design gap” in particular in analog/RF design: need for highly skilled human resources. need for methodologies in LV, LP, RF design
“Design automation gap”: in analog/RFIC design (vs. digital design)
Design gap exists also in Greece (Microelectronics Industry!)
Main field of research: design of low-voltage/low-power analog/RF integrated circuits
compact modelling in advanced semiconductor technology
Particular field of research: Next gen. nanoscale CMOS: multi-gate transistors (FinFET, DGFET)
high-voltage transistors (HVMOS) – RF, automotive applications e.a.
novel devices (SiC FETs) for high-current applications
Research Activities, Microelectronics Group
A. Environment
6 ΗΛΕΚΤΡΟΝΙΚ
Η Ι
Κωνσταντίνος
Μπάλας
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Need for last mile broadband access
With scaling of MOS devices down to the 22nm-regime
Power consumption becomes a stringent demand
Need for low-voltage, low-power circuit design
Microelectronics group
Millimetre-wave circuit design
Design of transceiver components (Low-Noise Amplifiers, Voltage-Controlled Oscillators, Variable-Gain Amplifiers)
MOS device modelling and characterization with EKV3 compact model
Research Activities, Microelectronics Group
Β. Motivation
7 ΗΛΕΚΤΡΟΝΙΚ
Η Ι
Κωνσταντίνος
Μπάλας
General Receiver Architecture
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
DC to RF & Noise on-wafer probing
8
RF probe station (on-wafer measurements in temperature controlled, shielded environment)
4 micromanipulators, microscope, T-controlled chuck
DC/RF probes contacting a CMOS wafer
RF Network Analyzer up to 26 GHz, Signal
generator, Spectrum analyzer, DC sources etc.
Source=Bulk
Gate Drain
Source=Bulk
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
0.00
0.01
0.02
0.03
0.04
0.05
0.06
0.07
0.0 0.2 0.4 0.6 0.8 1.0 1.2
VD [V]
ID [
A]
measured
EKV3.0
f = 300MHz
-100
-90
-80
-70
-60
-50
-40
-30
-20
-10
0
-1.2-1.1-1-0.9-0.8-0.7-0.6-0.5-0.4-0.3-0.2-0.1
VG [V]
Am
plitu
de [
db
m]
Fundamental
EKV3.0
2nd Harmonic
EKV3.0
3rd Harmonic
EKV3.0
DC , RF & noise on-wafer characterization of nano-scale semiconductor devices Microwave characterization (-> 26.5 GHz) Ultra-low currents (~1 pA … 100 mA) LCR (~10pF) Low-frequency Noise (~1 Hz … 100 kHz)
0
0.1
0.2
0.3
0.4
0.5
0.6
0.7
0.8
0.9
1
0.001 0.01 0.1 1 10 100 1000
IC = ID / Ispec [-]g
ms *
UT
/ I
D [
-]
10x10
10x2
10x1
10x0.5
10x0.3
10x0.25
10x0.2
10x0.16
10x0.14
10x0.135
10x0.125
0.1
1
10
100
1000
0.001 0.01 0.1 1 10 100 1000
IC = ID / Ispec [-]
VA
= ID
/gd
s [
1/V
]
10x10
10x2
10x1
10x0.5
10x0.3
10x0.25
10x0.2
10x0.16
10x0.14
10x0.135
10x0.125
Transconductance Efficiency
Early Voltage FT
Harmonic Distortion @RF
Research Activities in Microelectronics C. Research projects (i): DC to RF characterization
M. Bucher, A. Bazigos, S. Yoshitomi, N. Itoh, „A Scalable Advanced RF IC Design-Oriented MOSFET Model”, Int. Journal of RF and Microwave Computer Aided Engineering, Vol. 18, N° 4, pp. 314-325, July 2008.
9
Process design kits limitations on Frequency up to which MOS devices are
characterized
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Design of Analog / RF integrated circuits (RFICs) - Design Flow
Research Activities in Microelectronics
C. Research projects (ii): Analog/RFIC Design
10
EUROPRACTICE IC Service, offered by IMEC and Fraunhofer, offers
low-cost ASIC prototyping and ASIC small volume production ramp-up
to high volume production through Multi Project Wafer - MPW - and
dedicated wafer runs.
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Design of Analog / RF integrated circuits (RFICs) Design of integrated RF CMOS transceivers Design of low-voltage, low current, low power analog
ICs Ultra-low voltage circuit design techniques
Research Activities in Microelectronics
C. Research projects (ii): Analog/RFIC Design
HERAKLITOS II: Nanoscale RF CMOS Transceiver Design, Ministry of Education, 2010-2013. CORALLIA: NexGenMilliWave, Next Generation Millimeter Wave Backhaul Radio, Hellenic Technology Cluster Initiative in Microelectronics, Duration: 2009 – 2012.
RF LNA @ 30 GHz, 90nm CMOS LV/LP analog design (OTA), 65nm CMOS
11
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής 12
Research Activities in Microelectronics
C. Research projects (ii): Analog/RFIC Design
Design of Analog / RF integrated circuits (RFICs) TSMC 90nm process 1920 x1920 um 100 dies DC , CV & RF EKV3 modeling and characterization On Wafer Measurements 30 GHz LNA
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Development of Computer Aided Design (CAD) Tools EKV3 MOS transistor compact model
Multigate nanotransistor/FinFET compact modelling
High-Voltage MOSFET (LDMOS) compact modelling
Design automation of analog/RF building blocks
Research Activities in Microelectronics
C. Research projects (iii): Development of CAD Tools
Markers: Measurements
Blue Lines: Analytical Expressions
Green Lines: Analytical Expressions with RG=0
L = 70 nm, W = 2 μm, NF = 10
Freq=50MHz…20.5GHz; VGS = 0.8V; VDS = 0.8V; VSB = 0V;
Real (Y12) Real (Y22)
Imag (Y11) Imag (Y12) Imag (Y21) Imag (Y22)
Real (Y11) Real (Y21)
A. Bazigos, F. Krummenacher, J.-M. Sallese, M. Bucher, E. Seebacher, W. Posch, K. Molnar, M. Tang, “A Physics-Based Analytical Compact Model for the Drift Region of the HV-MOSFET”, IEEE Trans. on Electron Devices, Vol. 58, N° 6, pp. 1710-1721, 2011.
13
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
RFIC Lab Equipment & Software
Equipment • RF Probe Station semi-automatic, thermal probing (-65 oC to +200 oC) • Vector Network Analyzer HP 8510C (26.5 GHz) • RF Signal Generator, Rohde-Schwarz SMJ100A (6 GHz), arb. BB • Real-Time RF Spectrum Analyzer, Tektronix RSA2208A (8 GHz) • Mixed-Signal Oscilloscope, Agilent MSO6104 (1 GHz) • Precision LCR Meter, Agilent E4980A (2 MHz) • Dynamic Signal Analyzer, Agilent 35670A (100 kHz) • DC Semiconductor Parameter Analyzer HP 4142B, HP 4145A • Keithley Semiconductor Characterization System, 4200-SCS Software • Circuit simulation: Cadence IC & Systems, Agilent ADS, Dolphin Smash, Mentor
Graphics ELDO, ngspice • Instrument control, Parameter extraction: Agilent IC-CAP, VEE Pro 8, Cascade
Microtech PCS • TCAD simulation (2D/3D): Minimos, Silvaco Access to Europractice and MOSIS MPW (multi-project wafer) services
14
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
European Research Projects: FP7 “COMON”, Compact Modelling Network, Contract Nr. 218255, Marie Curie Industry-
Academia Partnership and Pathways (IAPP), 2008-2012. http://www.compactmodelling.eu/ FP6 “TARGET”, Top Amplifier Research in a European Team, Contract Nr. 507893, Network of
Excellence, 2004-2007.
Greek National Projects: HERAKLITOS II: Nanoscale CMOS Transceiver Design, Ministry of Education & Lifelong
Learning, 2010-2013. COOPERATION: NANOsympraxis, Multigate MOSFET nanotransistors: compact models for
current and noise – development of automated design tools for nanoelectronics, Contract Nr. 09-SYN-32-998, Ministry of Education & Lifelong Learning, 2010 – 2013.
COOPERATION: ANTI-SiC, Development of new transistors and inverter for photovoltaic systems based on Silicon Carbide, Contract Nr. 09-SYN-42-1181, Ministry of Education & Lifelong Learning, 2010 – 2013.
CORALLIA: MEMSENSE, MEMS Based Wireless Sensor Networks, Hellenic Technology Cluster Initiative in Microelectronics - Phase 2, 2009 – 2012.
CORALLIA: NexGenMilliWave, Next Generation Millimeter Wave Backhaul Radio, Hellenic Technology Cluster Initiative in Microelectronics - Phase 2, Duration: 2009 – 2012.
AKMON: Greek Ministry of Development, 2006 – 2008. PENED 03ED354: Power Amplifier Design for Metropolitan Wireless Networks Based on
802.16, Ministry of Development, 2006-2009.
Research Programs of the Microelectronics Group
15
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Direct Industry Relations Toshiba Semiconductor
Infineon Technologies
Intel
austriamicrosystems
Atmel Semiconductor
EM Microelectronic Marin SA
Corallia: Hellenic Technology Cluster Initiative in Microelectronics: www. corallia.org over ~50 companies in Microelectronics in Greece (~350 M€/yr. exports!)
THETA Microelectronics, HELIC, Prisma Electronics, Analogies, RAYCAP, ….
Technology transfer Compact modelling expertise
EKV3 (www.ekv3.tuc.gr) compact model developed (advanced CMOS)
DC to RF characterization
Ultra-low voltage/Low-power & RF design
Research Activities in Microelectronics
C. Technology Transfer/Industrial collaborations
16
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Collaborations (indicative)
AdMOS
Atmel Semiconductor
Austriamicrosystems
AUTH Thessaloniki
Cadence Design Systems
CEA-LETI
CERN
CSEM
Cypress Semiconductor
Dolphin Integration
EM Microelectronic
EPFL
FORTH-IESL
Helic
Infineon Technologies
Intel
ITE Warsaw
Mentor Graphics
Microchip
RAYCAP
Tektronix
TU-Dresden
THETA Microelectronics
Toshiba Semiconductor
UC Berkeley
UCL Louvain-La Neuve
UNCC Charlotte
Uni Kjeller
Uni Strasbourg
URV Tarragona
17
Optoelectronics Group
Electronics Laboratory
Dept. of Electronic & Computer Engineering
Technical University of Crete GR 73100 Chania, Crete, Greece
Costas Balas Associate Professor, electronics lab director and group leader
+30 28210 37212 balas“at” electronics.tuc.gr
www.electronics.tuc.gr
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
The European Commission has acknowledged the importance of Photonics by identifying it as a Key Enabling Technology for Europe.
“ Without strong European leadership in photonics technologies, these industries will be left vulnerable to strong competition from the USA and Asia”. (http://www.photonics21.org )
Photonics 21 EU initiative has named 21th century as the "photon century”
“Following the paradigm of the rapid evolution of electronics that followed the invention of the transistor in the late 1940’s, over the coming decades photonics will impact most areas of our lives, revolutionising societies and industries around the globe”.
Main areas of focus: Information and Communication , Life Science and Health, Emerging
Lighting, Electronics and Displays, Security, Metrology and Sensors,
Research Activities in Optoelectronics
A. Environment
19
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Three quarters of the global health care expenditure is currently spent on the symptomatic treatment of progressed illness.
Biophotonics has enormous potential as a key enabling technology to identify the root cause of diseases rather than easing existing Symptoms
Biophotonics will also greatly accelerate molecular diagnosis, and so constitute a great step towards personalized medicine and a better quality of life.
Our Focus: Life Science and Health (biophotonics)
20
Optoelectronics Group
Research areas
Dynamic Contrast Enhanced Molecular Optical Imaging
Hyperspectral Imaging
Scientific Instrumentation
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Dynamic Contrast Enhanced Molecular Imaging
22
It is based on signal emitting tracers (biomarkers) combined with sophisticated imaging modalities to detect changes at the molecular and genetic level.
Identifies cancer precursors before changes are detected at anatomical levels.
Provides info for understanding the molecular origins of cancer.
It holds the promise to become a sensitive and specific method to detect and prevent the progression of precancerous lesions.
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
DCE-OI
23
Normalized DDR curves, corresponding to 4
low grade (gray) and 4 high grade (black) cervical
neoplasias confirmed with biopsies.
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
DCE-MRI
24
Frederic G Dhermain et al
I
pH
:H+ :AC
:gap junctions, inactive in CIN
:tight junctions, loose in CIN
:ion buffers
Measuring the biomarker’s uptake kinetics , in vivo…..
copyright Costas Balas 2012
(a) Epithelial compartments and transport fluxes (b) The two-compartment cell model and transport fluxes
In silico simulation of biomarker uptake kinetics and of biomarker uptake kinetics
1 1 1
1 1 1 1 1
10
HIS
i i i
i i i i
CH AA AAi
IS ES m T
ES
Ac Ac H Hi
ES m m T p
d lnC q b J a K J
dt
w b J a K J a K J J
copyright Costas Balas 2012
Inverse problem formulation and solution
0 50 100 150 200 2500
0.1
0.2
0.3
0.4
0.5
0.6
0.7
time (sec)
No
rmali
zed
Dif
fuse
Refl
ecta
nce (
ND
R)
0 50 100 150 200 2500
0.1
0.2
0.3
0.4
0.5
0.6
0.7
No
rmali
zed
Co
ncen
trati
on
LG - 2
HG - 1
Param
eter LG1 LG2 LG3 LG4 HG1 HG2 HG3 HG4
b (μM) 0.11 0.17 0.30 0.25 0.310 0.28 0.18 0.26
βIS
(mM) 23.0 17.6 19.0 12.7 25.5 32.2 18.6 24.4
layers 3 6 7 7 11 10 9 10
pHES 6.46 6.78 6.91 6.97 6.01 6.03 6.04 6
In silico simulation Global sensitivity analysis
Global optimization/ biological parameter estimation
NRMSD<2%
copyright Costas Balas 2012
Major achievements on DCE-OI • Fist to develop DCE-OI worldwide • Numerous patents, awards, invited talks • Licensed technologies to industry/products in global markets • Costas Balas: Lead Guest Editor of Special Issue on Dynamic Contrast
Enhanced Imaging, International Journal of Biomedical Imaging 2012-2013 selected pubs • "Estimation of Neoplasia-Related Biological Parameters through Modeling
and Sensitivity Analysis of Optical Molecular Imaging Data" • G. Papoutsoglou, C. Balas
IEEE-Transactions on Biomedical Engineering, accepted • C. Balas “ A Novel Optical Imaging Method for the Early Detection,
Quantitative Grading and Mapping of Cancerous and Precancerous lesions of Cervix”, IEEE-Transactions on Biomedical Engineering, vol. 48, No 1, pp. 96-104, 2001
• C. Balas, G. Papoutsoglou, and A. Potirakis, “In vivo molecular imaging of cervical neoplasia using acetic acid as biomarker,” IEEE Journal of Selected Topics in Quantum Electronics, vol. 14, no. 1, pp. 29-42, Jan-Feb, 2008
W. P. Soutter, .., C. Balas. “Dynamic Spectral Imaging-Improving Colposcopy” Clinical Cancer Research 15, 1814, 2009
Hyperspectral Imaging
Developing new cameras and apps
Biomedical
a) Endoscopy
b) Microscopy
29
Beyond Biomedical
Non destructive analysis
of objects of artistic and historic
value
Hyper-Spectral Satellite Imaging
Our contribution: first to develop the all optical
imaging monochromator
Multi-dimensional data set
I@λ3
I@λ2
I@λ1
I@λ4
I@λ5
I@λΝ
•Imaging in a plurality of narrow
spectral bands- spectral cube
•Light intensity recorded in each
band is represented as coordinates
of a multi-dimensional (spectral)
space
• Spectrum: vector of a mutli-
dimensional color space
Development of Spectral Cameras
and Hyper-Spectral Microscopes
Specifications
Spatial resolution: 2 million spectra, one spectrum per pixel
Spectral range: 370-1000nm
Spectral resolution: 34 spectral bands (20nm FWHM)
Color and FCI modes
Scanning time: <1 mim
Real-time, HD-spectral imaging
Operation modes: Reflection, Transmission, Fluorescence
Spectral Classification Algorithms (SCA) I@λ3
I@λ2
I@λ1
I@λ4
I@λ5
I@λΝ
Y
X α
α=angle formed between ref, and test spectrum
X=test spectrum, Y=reference spectrum
YX = averages of X, Y
YM = sample mean vector of class Y
CY= sample covariance matrix of class Y
22
YYXX
YYXXR
22
1
)()(cos
Ya
values: (-1)-(+1)
• Spectral Angle Mapper (SAM)
values: 0o-90o
• Spectral Correlation Mapper (SCoM)
Hyperspectral Endoscopy
Seeing the Invisible….
Visible
Blood vessels Connective tissue
Advanced Hyperspectral Microscopes
Advanced Hyperspectral Microscopes ….offering quantification and mapping in real-time…
Quantitative mapping of estrogen/progesterone receptor expression in breast cells
Quantitative histology Leukemia detection/mapping
5D Microscopy for Detecting Circulating Tumor Cells (CTCs)
Imaging
detector
Multi-wavelength excitation
light source
Semi-transparent
mirror
Light sourcecontrol
Imaging monochromator control
Data transfer line
Imaging detectorcontrol
spectral cube image stack
Emission cube and spectrum
Excitation emission matrix (one per pixel) Pixel intensity response at different excitation –emission pairs
Excitation cube and spectrum
Micro-5DOutput
Detecting and assessing the metastatic potential of CTCs (OncoSeed Program) ….for personalizing treatments
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Hyperspectral Cameras for non destructive analysis of objects of artistic and historic value
I. Palimpsest (72 verso) – Mt. Athos
40
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Christ on the Cross, New Mexico
41
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
El Greco St Francis of Assisi
42
SCM
Realgar Minio Cinnabar Hematite Red lake dark Red lake light
-Red: Mix. Of Red lake dark and light
Realgar Minio Cinnabar Hematite Red lake dark light
Pigment identification in Paintings by El Greco
Achievements in Hyperspectral Imaging • The first to develop the all optical imaging
monochromator
• best paper awards
• Pubs Included in Nature-research highlights,
• Patents granted in US
• Technology licensing in EU and USA
• 150 installations world wide incl. Harvard, J&J, Getty
Selected pubs
C. Balas et al , “A Novel Spectral Microscope System: Application in Quantitative Pathology”, IEEE-Transactions on Biomedical Engineering, vol. 50,No. 2, pp. 207-217 N. Kantzilakis, E. Stiakaki, A. Ppadakis, H. Dimitriou, E. Stathopoulos, E. Markaki, C. Balas, M. Kalmanti, “Spectral characteristics of acute lymphoblastic leukemia in childhood”, Leukemia Research, 28 pp 1159-1164, 2004 C. Balas, V. Papadakis, N. Papadakis, A. Papadakis, E. Vazgiouraki, G. Themelis, “A Novel Hyper-Spectral Imaging Apparatus for the Non-Destructive Analysis of Objects of Artistic and Historic Value”, J. of Cultural Heritage, Vol: 4, Supplement 1, January, 2003, pp. 330-337 K. Melessanaki, V. Papadakis, C. Balas, D. Anglos: “Laser Induced Breakdown Spectroscopy (LIBS) and Hyper-spectral Imaging Analysis of Pigments on an Illuminated Manuscript”, Spectrochimica Acta, B: Atomic Spectroscopy, pp. 2337-2346, 2001
http://www.economist.com/node/3786393?story_id=3786393
Other special articles in “Science & Vie”, June 2004, The Times, CNN.com etc.
Installations in the most prestigious organizations
A NEW PROJECT STARTED : Quantitative assessment of the pupillary photomotor response dynamics to
tunable, narrow band stimuli Opening a window for
examining brain with light
the first binocular hyperspectral digital
pupillograher, capable of recording pupillary
responses to both monochromatic and
polychromatic stimuli
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Grants awarded in 2010
• OncoSeed Diagnostics: Biology of Circulating Tumour Cells, Distant Metastasis & Development of Liquid Biopsy Methods. Funding source: «COOPERATION»-SUB-ACTION ΙΙ:« Large Scale Cooperative Projects». Total budget: €2.000.000, TUC Budget €210.000
• In vivo molecular imaging of epithelial pre‐cancers based on dynamic optical scattering modeling. Funding source: Heraclitus II program for supporting graduate research. Budget €45.000
• Imaging system for assessing papillary response to tunable monochromatic light excitation. Funding source: TUC internal program for supporting graduate research. Budget €15.000
2009
• Contract research in collaboration with FP €30.000
2006-2008,
• ENTER (04-ENTER-72), (GSRT) €78.000
Funding
47
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Collaborations (indicative)
Imperial College London
St Mary's Hospital London
Hammersmith Hospital London
VU University, Amsterdam
University Medical Centre, Utrecht,
Erasmus University, Rotterdam
Harvard-Wellman Centre for Photomedicine, MA, USA
University of Pittsburgh, PE, USA
Institute Pasteur Paris &Athens
FORTH-IMBB
U-Ioannina
U-Patras
Corallia cluster
H-bio cluster initiative
Forth-Photonics Ltd UK, GR
Johnoson&Johnosn, NJ, USA
Neutrogena, CA, USA
IRIDEX, CA, USA
48
ΠΟΛΥΤΕΧΝΕΙΟ ΚΡΗΤΗΣ
ΤΜΗΜΑ ΗΜΜΥ, Εργ. Ηλεκτρονικής
Conclusions
Over the past years significant efforts directed towards attracting funds for purchasing and setting up (from scratch) lab equipment.
Today the lab’s research facilities are unique and can support ambitious research programs and help in attracting funding
The two activities of the Electronics Lab are unique in Greece and competitive worldwide
The Lab members have established long term collaborations with leading academic institutions. Dept’s students are benefited from this
The Lab members have a significant track record in innovation and technology transfer to industry. The Lab’s educational and research activities has the potential to play a leading role in the further development of the relevant industry in Greece and EU.
49