My hero, Linus Pauling
• 1945: Hypothesized that sickle disease resulted from a mutant Hb
• 1949: Demonstrated that sHb had a less negative ionic charge than normal Hb
Figure 11-12 Biologically Important Nucleophiles and Electrophiles
Figure 11-9 RNase S complexed with a nonhydrolyzable substrate.
Figure 11-10 Catalytic mechanism of RNase A.