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GAPDH & PFK
Oleh :
Neni Anggraeni (130120150011)
Tugas Mata Kuliah Gangguan Metabolisme & engenalann!a
Dosen Pengampu : Prof. Dr. M. NurhalimShahib, dr.
MAGISTER IM! "ED#"TERAN DASAR!NPAD$%&'
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GLYCERALDEHIDE 3-PHOSPHAT
DEHIDROGENASE
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GA"#
$n%im !ang mengaatalisis 'roses e enamalam gliolisis
gl()eraldeh(de *+phosphae D+gl()erae &,*+bisphosphae -&,*+PG/
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*NG+, -A,N GA"#
+bg sensor stres sel instrasel an estrasel. mam'umengati/an meanisme 'erbaian erusaan sel atau a'atmengati/an meanime a'o'tosis
ila terai stres osiati/. en%im ini menai tia ati/+ehingga sel a'at beralih /ungsi ari /ungsi metaboli e/ungsi untu menaga eseimbangan osiasireusi
eningatan GA"# an teraumulasi alam mitoonriaa'at mengati/an meanisme a'o'tosis Membranmitoonria menai im'remeabel an mele'asan /ator 'roa'o'toti an 4!torom 4
$s'resi abnormal en%im ini terlibat alam 'en!ait tertentu Terutama 'en!ait neuroegenerati/
Tristan. $t al 2011 The Diverse Functions of GAPDH : Views From DierentSubcelluar Compartmemnts N,# ubli4 A44es
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Tristan. $t al 2011 The Diverse Functions of GAPDH : Views From Dierent
Subcelluar Compartmemnts N,# ubli4 A44es
GA"# inasso4iation 6its
4!toseletonan 7esi4ulartrans'ort
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GA"# in mito4honria
Tristan. $t al 2011 The Diverse Functions of GAPDH : Views From DierentSubcelluar Compartmemnts N,# ubli4 A44es
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Tristan. $t al 2011 The Diverse Functions of GAPDH : Views From DierentSubcelluar Compartmemnts N,# ubli4 A44es
GA"# in Nu4leus
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GA"# sbg House!eepin""ene 8umlah gen !g teres'resi harus i baningan engan
umlah gen !g ban!a teres'resi 'aa selaringantersebut House!eepin" "ene
GA"# meru'aan salah satu houseee'ing gene !ang
'aling umum igunaan untu membaningan umlahgen9gen !ang teres'resi
arber. obert " $t al 2005 GAPDH as a house!eepin" "ene :anal#sis of GAPDH m$%A e&pression in a panel of '( human
tissuesh!siol Genomi4s
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arber. obert " $t al 2005 GAPDH as a house!eepin" "ene :anal#sis of GAPDH m$%A e&pression in a panel of '( human
8umlah mNAGA"# untu
setia' aringan
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arber. obert " $t al 2005 GAPDH as a house!eepin" "ene :
anal#sis of GAPDH m$%A e&pression in a panel of '( humantissuesh siol Genomi4s
Tia aa 'erbeaan e'resi GA"# antara lai9laian 'erem'uan
Tia tera'at 'erbeaan es'resi GA"# 'aa'erbeaan usia
erbeaan es'resi 'aa berbagai aringanmen4erminan /ungsi GA"# ialam sel
$s'resi GA"# !ang tinggi tera'at 'aa aringan!g membutuhan energi !g tinggi Otot. antung
(7entriel iri) an ota
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FOSFOFRUKTOKINASE
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$n%im ini a'at ihambat atau irangsang olehbebera'a metabolit. !aitu sen!a6a !ang terlibatalam 'roses gliolisis
AT berlebih an asam sitrat a'at menghambat
era /os/o/utoinase Namun. isaat !ang samaa'at 'ula merangsang en%im ini engan aan!a
e/etor 'ositi/ ari AM. A". an /utosa9
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ebera'a 'enelitian menunuan bah6a ati@tas K meningat'aa 4an4er 4ell line. begitu uga 'aa sel 'rimer tumor sgbres'on 'roli/erasi sel
Ati7itas K menai target 'engobatan 'aa aner Tuuann!auntu membatasi ati7itas gliolisis 'aa sel tersebut
Al #a6a6i. Naa 201> Phosphofructo!inase: A me)iator of "l#col#tic *u& in cancer
pro"ression $l+$?,$ riti4al e7ie6 in On4olog!#ematolog!