8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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Nglg Gvrxgsskal Ofjlngs kl Fwejl Ogccsji}gx Gvraswxg }a Iaxejcmgf{mg kl yk}xa jlm kl ykya
_kealg Lgwss# Rf,M,HJ_I _G# Cwm~knsfjigl
Iaxejcmgf{mg _okglog Oaligxglog# Ejmxkm 82:8
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g 8
8
Aw}cklg
• Kl}xamwo}kal
:, Nglg gvrxgsskal jljc{sks
8, Rxklokrcg ai ekoxajxxj{ nglg gvrxgsskal jljc{sks
• Xgswc}s
:, Giigo}s ai Iaxejcmgf{mg &IJ+ gvraswxg al nglg gvrxgsskal
kl ljsjc grk}fgckjc ogccs wlmgx gvrgxkegl}jc oalmk}kals
K, Nglg gvrxgsskal ofjlngs kl owc}wxgm fwejl ljsjc grk}fgckjc ogccs &FLGO+,
KK, Xgcj}kalsfkr hg}~ggl nglg gvrxgsskal ofjlngs jlm ngla}avkok}{,
KKK, Oaerjxksal ~k}f mj}j ah}jklgm kl jl kl ykya xj} klfjcj}kal s}wm{,
KY, _weejx{ K
8, Giigo}s ai Iaxejcmgf{mg &IJ+ klfjcj}kal al nglg gvrxgsskal
kl jl klfjcj}kal s}wm{ ~k}f fwejl yacwl}ggxs
K, Rxklokrcg ai klfjcj}kal s}wm{
KK, Nglg gvrxgsskal ofjlngs kl ljsjc hkarskgs
KKK, Nglg gvrxgsskal ofjlngs kl rgxkrfgxjc hcaam
KY, _weejx{ KK
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g ?
?
Nglg gvrxgsskal jljc{sks
• ]xjmk}kaljc jrrxajof4 gvjeklkln jlm oaccgo}kln mj}j al j sklncg nglg j} j }keg,
• ]amj{4 fjlmckln ai mj}j kl j ncahjc ijsfkal Nglaekos,
• Nglaekos ks }fg s}wm{ ai jcc }fg nglgs ai j ogcc# ax }ksswg# j} }fg MLJ &ngla}{rg+# eXLJ&}xjlsoxkr}aeg+# ax rxa}gkl &rxa}gaeg+ cgygc,
• ]avkoanglaekos4
• mgjcs ~k}f }fg oaccgo}kal# kl}gxrxg}j}kal jlm s}axjng ai kliaxej}kal jhaw} nglgjo}kyk}{ ~k}fkl rjx}kowcjx ogccs ax }ksswgs ai jl axnjlkse kl xgsralsg }a }avkoswhs}jlogs,
• oaehklgs }avkoacan{ ~k}f nglaekos4
gcwokmj}kal ai eacgowcjx egofjlkses jlm mgxkyj}kal ai eacgowcjx gvrxgsskalrj}}gxls &k,g, eacgowcjx hkaejx`gxs+ }fj} rxgmko} }avkok}{ ax }fg nglg}koswsogr}khkck}{ }a k},
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g =
=
Nglaekos4 Oal}xkhw}kal }a }fg }avkoacankojc rxaikcg ai IJ
Rasskhcg oal}xkhw}kal4
•Jc}gxj}kals kl nglg gvrxgsskal kl ogccs ! }ksswgs gvrasgm }a IJ,
•_gjxof iax rj}f~j{s jiigo}gm h{ IJ gvraswxg,
•_gjxof iax nglg ejx`gxs ai IJ gvraswxg,
•Kmgl}kikoj}kal ai }fxgsfacms iax IJ%klmwogm }avkok}{,
•Jrrckoj}kal iax zwjl}k}j}kyg xks` gs}kej}kal,
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g 7
7
Najc
• Ks }fg gvrxgsskal ai nglgs kl ogccs jlm }ksswg j} }fg sk}g ai ikxs} oal}jo} jc}gxgm ji}gx IJ
klfjcj}kal1
• Rgxiaxejlog ai nglg gvrxgsskal jljc{sks ~k}f MLJ ekoxajxxj{s,
• MLJ ekoxajxxj{s jxg wsgm }a egjswxg ofjlngs kl nglg gvrxgsskal cgygcs ai cjxng
lwehgxs ai nglgs skewc}jlgawsc{,
• Rjx}kowcjx kl}gxgs} kl4• nglgs klyacygm kl }fg mg}avkikoj}kal ai IJ &g,n, IMF# JCMF:J:# JCMF8+
• nglgs klyacygm kl }fg xgrjkx ai IJ%klmwogm MLJ mjejng &g,n, LGX# FX#IJLO!HXOJ xgrjkx rj}f~j{+
• _k}g ai ikxs} oal}jo} mwxkln IJ klfjcj}kal ks }fg ljsjc grk}fgckwe,• gvrgxkegl}s kl yk}xa &FLGO+ jlm
• gvrgxkegl}s ji}gx klfjcj}kyg gvraswxg }a IJ kl ykya ,
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g 9
9
Rxklokrcg ai ekoxajxxj{ nglg gvrxgsskal jljc{sks
• Ksacj}kal ai XLJ,
• _{l}fgsks ai oMLJ,
• F{hxkmksj}kal ai oXLJ}a ‖‖iwcc nglaeg fwejl ekoxajxxj{s–&W:??Rcws 8,2# Jii{eg}xkv+,
• Laxejcksj}kal ai xj~ mj}j jlmojcowcj}kal ai ‖‖can8 kl}glsk}{ gvrxgsskal
sweejx{ yjcwgs– &XEJ+,
• Kmgl}kikoj}kal ai mkiigxgl}kjc{gvrxgssgm nglgs &r ≭ 2,27 &} %}gs}+#8%iacm ofjlng+,
• Nglg Al}acan{ &NA+ Eklgx Jljc{sks4Kmgl}kikoj}kal ai ejklc{ jiigo}gm hkacankojcrxaogssgs,
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g >
>
Giigo} ai IJ al nglg gvrxgsskal kl FLGOkl yk}xa
▴ ]keg% jlm oalogl}xj}kal%mgrglmgl} ofjlngs kl nglg gvrxgsskal,
]xgj}egl}lwehgx ai
jc}gxgm nglgs$
wr%xgnwcj}gm
nglgs
ma~l%xgnwcj}gm
nglgs
72·E IJ 8f : 2 ::22·E IJ 8f = 2 =
72·E IJ =f 9 : 7
:22·E IJ =f :7? :> :?9
822·E IJ =f 66> :>6 >2;
:22·E IJ 8=f : 2 :822·E IJ 8=f = = 2
= v 82·E IJ$$ 2 2 2
= v 72·E IJ$$ :=? 7> 69
$ j} cgjs} ≧ 8%iacm ofjlng
$$ ~k}f 8= f kl}gxyjcs
Lgwss _, g} jc,# ]avkoac Cg}}, 82:2 Ao} 70:;6&8+486;%;7
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g 6
6
]fg xgcj}kalsfkr hg}~ggl ofjlngs kl nglg gvrxgsskal
jlm ngla}avko giigo}s
Ngla}avkok}{ ai IJ kl yk}xa % Oaeg} Jssj{
Mg}go}kal ai IJ%klmwogm MRV• ]xgj}egl} ai FLGO ~k}f IJ,
• Kxxjmkj}kal ai }xgj}gm owc}wxgs jlm oal}xacs ~k}f 8N{,
Xgmwo}kal ai ο%xj{%klmwogm MLJ eknxj}kalklmkoj}gs klmwo}kal ai MRV,
Xgrjkx ai IJ%klmwogm MRV
• Ras}klowhj}kal ai IJ%}xgj}gm owc}wxgs &?>²O+,Kxxjmkj}kal ~k}f 8N{,
Jhack}kal ai IJ%klmwogm xgmwo}kal ai MLJ eknxj}kalklmkoj}gs xgeayjc ai MRV,
Rjxjeg}gx4 ]jkc eaegl}&~gknf}gm rxamwo} ai }jkc kl}glsk}{ jlm }jkc cgln}f+
kxxjmkj}gm ~k}f 8N{
oal}xac
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g ;
;
Klmwo}kal jlm xgrjkx ai MRV kl fwejl ljsjc grk}fgckjc ogccs &FLGO+
kl yk}xa ji}gx IJ%}xgj}egl} iax :f
▴ Oalogl}xj}kal%mgrglmgl} klmwo}kal ai MRV,▴ Xgrjkx mwxkln 6f,
2
:
8
?
=
7
9
>
6
O a 8 N {
: 2 2 ·
E + 8 N
{
8 2 2 ·
E + 8 N
{ O a 8 N {
: 2 2 · E +
8 N {
8 2 2 ·
E + 8 N
{ O a 8 N {
: 2 2 · E +
8 N {
8 2 2 ·
E + 8 N
{
Iaxejcmgf{mg
] j k c e a e g l }
$$
$$
:f }xgj}egl} =f ras}%klowhj}kal 6f ras}%klowhj}kal
Lgwss _, g} jc,# ]avkoac Cg}}, 82:2 Ao} 70:;6&8+486;%;7
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g :2
:2
Klmwo}kal jlm xgrjkx ai MRV kl FLGO kl yk}xa ji}gx oal}klwaws
}xgj}egl} ~k}f IJ
▴ Klmwo}kal ai MRV aygx j calngx rgxkam ai }keg &IJ xgejkls jo}kyg kl egmkwe+,▴ Oal}klwaws xgrjkx &gv}gl} mgrglms al s}xgln}f ai klmwo}kal+,
2
:
8
?
=
7
9
>
O a 8 N {
: 2 2 · E +
8 N {
8 2 2 · E +
8 N { O a 8 N
{
: 2 2 ·
E + 8 N
{
8 2 2 · E +
8 N { O a 8 N
{
: 2 2 · E +
8 N {
8 2 2 ·
E + 8 N
{
Iaxejcmgf{mg
] j k c e a e g l }
$$
$$
$$
$$
:f }xgj}egl} =f }xgj}egl} 8=f }xgj}egl}
$
Lgwss _, g} jc,# ]avkoac Cg}}, 82:2 Ao} 70:;6&8+486;%;7
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g ::
2
:
8
?
=
7
9
>
6
Oa 8N{ 82·E8N{ 72·E8N{
Iaxejcmgf{mg
] j k c e a e g l }
::
Klmwo}kal jlm xgrjkx ai MRV kl FLGO kl yk}xa ji}gx }xgj}egl}
~k}f ca~ IJ oalogl}xj}kals iax = mj{s$
$ = }xgj}egl}s ~k}f }keg kl}gxyjcs ai 8=f# egjswxgegl} ai MRV :f ji}gx }fg cjs} }xgj}egl},
▴ La oxassckl`kln giigo} ji}gx xgrgj}gm }xgj}egl} ~k}f ca~ IJ oalogl}xj}kals,▴ La joowewcj}kal ai MRV,
Lgwss _, g} jc,# ]avkoac Cg}}, 82:2 Ao} 70:;6&8+486;%;7
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_kealg Lgwss :;,2=,82:8
_gk}g :8
:8
^fkof nglgs jxg wr%xgnwcj}gm kl FLGO ji}gx gvraswxg }a IJ1
Fgj} ejr
NAEklgx Jljc{sks &822 ·E IJ# = f+
▴ Jiigo}gm hkacankojc rj}f~j{s jxg la} xgcj}gm}a }fg srgokiko jo}kal ai IJ,
NA oj}gnax{Nglgs kl
oj}gnax{$
lwehgx ai wr%xgnwcj}gm
nglgs$$
wr%xgnwcj}gm
nglgs P'U
fgj} sfao` rxa}gkl hklmkln ?> 8 7,=:
ofxaej}kl :8; 6 9,82
`kljsg klfkhk}ax jo}kyk}{ ?8 8 9,87
ogcc o{ocg jxxgs} 98 = 9,=7
glmaxkhalwocgjsg jo}kyk}{ 86 8 >,:=
rxa}gkl ̀kljsg klfkhk}ax jo}kyk}{ 86 8 >,:=
ofxaej}kl jssgehc{ ax
mksjssgehc{;7 > >,?>
xgnwcj}kal ai o{ockl mgrglmgl}
rxa}gkl ̀ kljsg jo}kyk}{
?7 ? 6,7>
lwocgasaeg jssgehc{ 77 7 ;,2;
glmasaeg }xjlsrax} 88 8 ;,2;
egmkj}ax oaercgv 82 8 :2,22
lwocgasaeg =7 7 ::,::
xgnwcj}kal ai jlnkanglgsks 88 ? :?,9=
xgsralsg }a wliacmgm rxa}gkl =7 > :7,79
xgsralsg }a rxa}gkl s}kewcws =7 > :7,79$ oj}gnaxkgs ~k}f < ; nglgs
$$ ≧ 8%iacm ofjlngm oaerjxgm }a wl}xgj}gm oal}xac
Lgwss _, g} jc,# ]avkoac Cg}}, 82:2 Ao} 70:;6&8+486;%;7
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_kealg Lgwss :;,2=,82:8
_gk}g :?
:?
Jlmgxsgl g} jc,# 82264Kl ykya
klfjcj}kal s}wm{ ~k}f xj}s
• Xgrgj}gm gvraswxg wr }a 9 rre IJ iax ? ~gg`s,
• ]keg% jlm oalogl}xj}kal%mgrglmgl} ofjlngs kl nglg gvrxgsskal,
• _klncg gvraswxg ai xj}s ~k}f :7 rre IJ iax 9f,
• NAEklgx Jljc{sks4 eas} sglsk}kyg ofjlngs iax nglgs jssaokj}gm ~k}f }fg
NA oj}gnaxkgs ‖‖gv}xjogccwcjx oaeralgl}– jlm ‖‖rcjsej egehxjlg–,
Jlmgxsgl E,G, g} jc,# ]avkoac _ok, 8226 Ao}0:27&8+4?96%6?
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_kealg Lgwss :;,2=,82:8
_gk}g :=
:=
Oaerjxksal ai NA oj}gnaxkgs kl yk}xa &FLGO+ ‟ kl ykya &xj}s+
▴ Hkacankojc rj}f~j{s xgicgo} nglgxjc xgjo}kal }a ogccwcjx s}xgss,
Lx NA Oj}gnax{r%Yjcwg aygx
&FLGO$$+ ≭
Rgxogl} ai wrxgnwcj}gm nglgs
&FLGO+ kl oj}gnax{ &'+
r%Yjcwg aygx
&xj}s$$$+ ≭
Rgxogl} ai wrxgnwcj}gm nglgs
&xj}s+ kl oj}gnax{ &'+
: NA422279?= Lwocgws 2,222: :,>2 2,2289 :,62
8 NA42229?72 ]xjlsoxkr}kal 2,222: 8,22 2,2?>6 :,>2
8,: NA42229?7: ]xjlsoxkr}kal# MLJ%mgrglmgl} 2,222: :,;2 2,2?6? :,62
? NA422:9897 Mgj}f 2,222: ?,82 2,222: ?,?2
?,: NA422268:; Ogcc mgj}f 2,222: ?,?2 2,222: ?,?2
?,:,: NA422:872: Rxanxjeegm ogcc mgj}f 2,222: ?,=2 2,2228 ?,:2
?,:,:,: NA42229;:7 Jrar}asks 2,222: ?,=2 2,2228 ?,82
= NA42229;72 Xgsralsg }a s}xgss 2,222: 8,?2 2,2222 ?,72
=,: NA4227:>6; Xgsralsg }a rxa}gkl s}kewcws 2,222: :7,92 2,2886 >,>2=,:,: NA42229;69 Xgsralsg }a wliacmgm rxa}gkl 2,222: :7,92 2,2886 >,>2
7 NA422?:?8? Xgnwcj}kal ai eg}jhackse 2,222: :,62 2,22?: 8,22
7,: NA422?:?8? Xgnwcj}kal ai ogccwcjx eg}jhackse 2,222: :,62 2,22=8 8,22
7,:,: NA422:;8:;
Xgnwcj}kal ai lwocgahjsg#
lwocgaskmg# lwocga}kmg jlm lwocgko
jokm eg}jhackse
2,222: :,;2 2,28?; :,62
$ nglgs kl oj}gnaxkgs ~k}f j} cgjs} ≧ 8%iacm wrxgnwcj}kal
$$ NA oj}gnaxkgs ~k}f }fg ca~gs} r%yjcwg iax jl glxkofegl} ai wrxgnwcj}gm nglgs
$$$ mg}gxeklgm ixae xj~ mj}j rwhcksfgm h{ Jlmgxsgl g} jc, &8226+
]ar 7 ai NA Oj}gnaxkg Nxawrs iax ]xjlsoxkr}s Wrxgnwcj}gm h{ 822·E Iaxejcmgf{mg &IJ+ ]xgj}egl} iax = f kl FLGO sax}gm h{ r%Yjcwg aygx kl Oaerjxksal
~k}f Xj}s Gvrasgm }a :7rre IJ iax 9 f h{ Klfjcj}kal$
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g :7
:7
Jlmgxsgl g} jc,# 82:24 Kl ykya klfjcj}kal s}wm{ ~k}f xj}s
• 2,># 8# 9# :2 ax :7 rre IJ iax :# = jlm :? ~gg`s &9f rgx m# 7 m rgx ~gg`+
• ]keg jlm oalogl}xj}kal mgrglmgl} jc}gxj}kals kl nglg gvrxgsskal,
• 8 rre4 Wrxgnwcj}kal ai nglgs jssaokj}gm ~k}f ogccwcjx s}xgss# }fkac }xjlsrax}! xgmwo}kal# klicjeej}kal jlm ogcc rxackigxj}kal,
• ≧ 9 rre4
• Glxkofegl} ai rj}f~j{s klyacygm kl ogcc o{ocg# MLJ xgrjkx# jrar}asks &MLJ%xgrckoj}kal s}xgss# glfjlogm rxackigxj}kal# eg}jrcjskj# jlm s}ge ogcc%lkofgjo}kyj}kal+,
• Fks}arj}facankojc ofjlngs jlm glfjlogm ogcc rxackigxj}kal,
Jlmgxsgl E,G, g} jc,# ]avkoac _ok, 82:2 Mgo0::6&8+4>:9%?:
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
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_kealg Lgwss :;,2=,82:8
_gk}g :9
:9
_glsk}kyg xgsralsg nglgs
• :7 nglgs wrxgnwcj}gm &:,7%iacm+ j} 8 rre gvraswxg iax 7 mj{s &Jlmgxsgl g} jc,# 8226+
• > ai }fgsg wrxgnwcj}gm j} 9 rre ji}gx gvraswxg iax :# = ax :? ~gg`s
&Jlmgxsgl g} jc,# 82:2+–_glsk}kyg Xgsralsg Nglgs–4
• Xgrxgsgl}kln gv}xjogccwcjx xgsralsg }a kxxk}jlo{# xgmwo}kal ai rcjsej egehxjlgjl}kavkmjl} }fkacs,
• Xgicgo} xgsralsgs }a ejkl}jkl xgmwogm }fkacs jlm gvrax} N_F }a gv}xjogccwcjx srjogs,
• Fa~gygx# }fg hkacankojc xgcgyjlog ai }fg ca~ masg nglg xgsralsg ks wlocgjx,
Jlmgxsgl E,G, g} jc,# ]avkoac _ok, 82:2 Mgo0::6&8+4>:9%?:Jlmgxsgl E,G, g} jc,# ]avkoac _ok, 8226 Ao}0:27&8+4?96%6?
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_kealg Lgwss :;,2=,82:8
_gk}g :>
:>
_weejx{ K
• ]fg gvrxgsskal ai IMF jlm a}fgx nglgs ejklc{ klyacygm kl }fg mg}avkikoj}kal ai IJ
ks la} glfjlogm kl FLGO gvrasgm }a IJ,
• Lalg ai }fg ejkl MLJ xgrjkx rj}f~j{s iax }fg xgeayjc ai MRV sgges }a hgklmwogm kl FLGO gvrasgm }a IJ wlmgx oalmk}kals klmkoj}kln xgrjkx jo}kyk}{ kl }fg
oaeg} jssj{,
• Hkacankojc rj}f~j{s sfa~ xj}fgx wlsrgokiko ogccwcjx xgjo}kals# klmwogm h{ nglgxjc
s}xgss,
• Ofjlngs kl nglg gvrxgsskal jxg jooaerjlkgm h{ ngla}avko giigo}s ji}gx jow}g
}xgj}egl},
• Xgrgj}gm }xgj}egl}s ai FLGO ~k}f ca~ IJ oalogl}xj}kals cgjm }a nglg gvrxgsskal
ofjlngs kl }fg jhsglog ai ngla}avko giigo}s,
• Oaerjxksal hg}~ggl kl yk}xa mj}j &FLGO+ jlm kl ykya mj}j ai j xj} klfjcj}kal s}wm{xgygjcs alc{ j ig~ oaeealc{ wr%xgnwcj}gm nglgs,
Iwlmjegl}jc rxaogssgs jxg oalsks}gl} hw} alc{ xgicgo} nglgxjc xgjo}kals ai ogccs
}a j }avko j}}jo`,
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_kealg Lgwss :;,2=,82:8
_gk}g :6
:6
Klfjcj}kal s}wm{ ~k}f fwejl yacwl}ggxs
• Rgxiaxegm j} }fg “Kls}k}w} ióx Jxhgk}s% wlm _atkjcegmktkl–
Wlkygxsk}{ ai Fgkmgchgxn &Rxai, ]xkghkn+,
• Klfjcj}kal s}wm{ }a klygs}knj}g ofgeasglsaxko jlm ngla}avko giigo}s ai IJ~k}f =: ejcg swhdgo}s,
• Mgiklgm oxk}gxkj iax klocwskal jlm gvocwskal ai yacwl}ggxs,
• Xjlmaeksgm gvraswxg rxa}aoac iax 7 mj{s &Ealmj{ }a Ixkmj{+#
= fawxs rgx mj{,
• Ikyg iaxejcmgf{mg oalogl}xj}kals &20 2,?0 2,=0 2,70 2,> rre+,
• Rgj`s4 =v:7 eklw}gs 2,9 wlm 2,6 rre IJ
mwxkln gvraswxg ~k}f 2,? wlm 2,= rre IJ,
• Hko{ocg gvgxoksgs &= v :7 ekl0 62 ^+ mwxkln gvraswxg,
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
http://slidepdf.com/reader/full/gene-expression-changes-in-human-cells-by-simone-neuss 19/24
_kealg Lgwss :;,2=,82:8
_gk}g :;
:;
Gvraswxg rxa}aoac
• 8: swhdgo}s ~k}f }fg fknfgs} gvraswxg &2,> rre IJ+ al ]wgsmj{# ]fwxsmj{ axIxkmj{,
• Ljsjc hkarskgs jlm hcaam }a klygs}knj}g nglg gvrxgsskal ofjlngs,
• _jerckln4 Ealmj{ hgiaxg gvraswxg ‟ Ixkmj{ ji}gx cjs} gvraswxg,
Mj{ ai 2,> rre
GvraswxgNxawr Lwehgx Ealmj{ ]wgsmj{ ^gmlgsmj{ ]fwxsmj{ Ixkmj{
? 8 O G M H J
:8 = O G M H J
6 ? O M J G H
:: = J M H G O
: = J H O M G
; = M J H O G
$ 2 rre gvraswxg al Ixkmj{
O 5 2,= rre rcws = rgj`s ai 2,6 rre iax jhaw} :7 ekl0M 5 2,7 rre0 G 5 2,> rre
]wgsmj{$
]fwxsmj{
Ixkmj{
J 5 2 rre0 H 5 2,? rre rcws = rgj`s ai 2,9 rre iax jhaw} :7 ekl0
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
http://slidepdf.com/reader/full/gene-expression-changes-in-human-cells-by-simone-neuss 20/24
_kealg Lgwss :;,2=,82:8
_gk}g 82
82
Nglg gvrxgsskal ofjlngs kl ljsjc hkarskgs ai IJ gvrasgm swhdgo}s
Oaerjxksal ai nxawrs hgiaxg gvraswxg4
]wgsmj{%]fwxsmj{ 4 ; nglgs ↚# 8= nglgs ↟
]fwxsmj{%Ixkmj{ 4 8 nglgs ↚# = nglgs ↟
]wgsmj{%Ixkmj{ 4 = nglgs ↚# 92 nglgs ↟
▴ Ejxnkljc giigo}s# la} xgcj}gm }a IJ gvraswxg,
fknfgs}
gvraswxg
lwehgx ai jc}gxgm
nglgs
wr%xgnwcj}gm
nglgs
ma~l%xgnwcj}gm
nglgs
]wgsmj{ :> = :?
]fwxsmj{ 8 : :
Ixkmj{ 6 9 8
Tgccgx D, g} jc,# Ew}jnglgsks, 82:: Dwc089&=+4777%9:
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
http://slidepdf.com/reader/full/gene-expression-changes-in-human-cells-by-simone-neuss 21/24
_kealg Lgwss :;,2=,82:8
_gk}g 8:
8:
Nglg gvrxgsskal ofjlngs kl hcaam ai IJ gvrasgm swhdgo}s
Oaerjxksal ai nawrs hgiaxg gvraswxg4
]wgsmj{%]fwxsmj{ 4 :9 nglgs ↚# 8 nglgs↟
]fwxsmj{%Ixkmj{ 4 8 nglgs ↚# > nglgs ↟
]wgsmj{%Ixkmj{ 4 8 nglgs ↚
▴ Ejxnkljc giigo}s# la} xgcj}gm }a IJ gvraswxg,
fknfgs}
gvraswxg
lwehgx ai jc}gxgm
nglgs
wr%xgnwcj}gm
nglgs
ma~l%xgnwcj}gm
nglgs]wgsmj{ 8 : :
]fwxsmj{ ; = 7
Ixkmj{ 2 2 2
Tgccgx D, g} jc,# Ew}jnglgsks, 82:: Dwc089&=+4777%9:
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
http://slidepdf.com/reader/full/gene-expression-changes-in-human-cells-by-simone-neuss 22/24
_kealg Lgwss :;,2=,82:8
_gk}g 88
88
Nglg gvrxgsskal ofjlngs kl rgxkrfgxjc hcaam
gvrasgm }a IJ kl yk}xa
• Hcaam ai 7 mkiigxgl} swhdgo}s &ejcg# lalsea`gxs+,
• IJ }xgj}egl} iax = fawxs kl yk}xa,
• Nglg gvrxgsskal jljc{sks,
▴ Mkxgo} }xgj}egl} ~k}f fknf IJ oalogl}xj}kals cgjms }a giigo}s kl fwejl hcaam,▴ Giigo}s kl hcaam jxg cgss rxalawlogm }fjl kl FLGO,
}xgj}egl} ~k}f
iaxejcmgf{mg
lwehgx ai jc}gxgm
nglgs
wr%xgnwcj}gm
nglgs
ma~l%xgnwcj}gm
nglgs
72·E 2 2 2
:22·E 2 2 2
822·E ?=8 :6 ?8=
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
http://slidepdf.com/reader/full/gene-expression-changes-in-human-cells-by-simone-neuss 23/24
_kealg Lgwss :;,2=,82:8
_gk}g 8?
8?
_weejx{ KK
• La hkacankojcc{ xgcgyjl} ofjlngs kl nglg gvrxgsskal
• kl ljsjc hkarskgs ai fwejl yacwl}ggxs ji}gx gvraswxg }a IJ wr }a 2,> rre
• kl rgxkrfgxjc hcaam ai fwejl yacwl}ggxs ji}gx gvraswxg }a IJ wr }a 2,> rre,
• ]fg hkacankojc xgcgyjlog ai ca~ masg nglg xgsralsgs &xj} lasg+ ks wlocgjx,
• ]fg hkacankojc egofjlkse cgjmkln }a ofjlngs kl nglg gvrxgsskal ji}gx IJ gvraswxg ks
wlocgjx,
• ]fg xgcj}kalsfkr hg}~ggl ofjlngs kl nglg gvrxgsskal jlm }fg rxaogss aiojxoklanglgsks ks wlocgjx,
Iwx}fgx klygs}knj}kals jxg lggmgm }a gcwokmj}g }fg wsgiwclgss ai nglg gvrxgsskal
ofjlngs iax }fg mg}gxeklj}kal ai }fxgsfacms jlm iax xks` jssgssegl},
8/2/2019 Gene Expression Changes in Human Cells by Simone Neuss
http://slidepdf.com/reader/full/gene-expression-changes-in-human-cells-by-simone-neuss 24/24
_kealg Lgwss :;,2=,82:8
_gk}g 8=
8=
_rgokjc }fjl`s }a
Oaargxj}kal rjx}lgxs4
• Ngxfjxm ]xkghkn# Dùxn Eóccgx
Kls}k}w} ióx Jxhgk}s%wlm _atkjcegmktkl
Wlkygxsk}í} Fgkmgchgxn
• Ofxks}arf @cklnejll
Fjcs%Ljsgl%Afxgl`cklk`
Wlkygxsk}í} Fgkmgchgxn
• @jxcfgklt Factejll#
Ekoxajxxj{%Oaxg Ijokck}{
Wlkygxsk}í}s`cklk`we Wce
• Hjxhjxj Eùrrs#
Kls}k}w} ióx Rfjxej`acankg
wlm ]avk`acankg
Wlkygxsk}í} Wce
• Fgklt%Rg}gx Ngch`g
IaxejOjxg
N_N Wce4• Nól}gx _rgk}• Djsekl Tgccgx
• _}gijlkg @óflgx• Xgnklj Cklsgleg{gx• Rg}xj _ofó}t
Ikljlokjc swrrax}4 OGIKO ! IaxejOjxg
]fjl` {aw iax {awx j}}gl}kal*