Anal
Introdcapillardisease(PAH) phase-cparameaccelerwith prshape oinflow pulmonand patMaterifemale(male:5(Siemetriggerivelocitimages(MPA)interestimageshemodpeak flin flowStudennormalResultin PAHrespect3.69 1MPA w(189.51of 1 listemax.not onldifferenDiscushighly hemodWhen tthe resof patiegroup. parame
more putilizedtwo grtreatmepresentpatientexhibitother pinformRefere1. Simoal. (19150:10
lysis of the He
duction: Patients ries. Symptoms sue with a markedlywhich is one of th
contrast MR imageters [2]. Hemodyration time and arrimary pulmonaryof the arterial pres( ) and outflow
nary vascular resistients with PAH. ials and Methods:7; age:42 17 y/o5; female:7; age:3ens Sonata, Erlaning. A 2D FLASHty-encoding gradies and phase image, right pulmonaryt (ROI) of cross-ss and were appliedynamic parameterlow rate (acceleratw rate during ejent’s t-test was usel subjects and PAHts: Fig. 1 showed tH patients and ntively (p<0.001). 1.19 L/s2 (p<0.05)was 361.33 104.11 65.70; p<0.001
of MPA and ed all hemodynam⁄ and the defly MPA but also ance between two g
ssion and Conclucorrelated with th
dynamic parameterthe pressure in puistance and the ents is significantlIn addition, the ra
eter of force. PAH
power against highd to estimate the croups is indistinguent phases of PAHt. For further studyts into different tt satisfied performphysiological para
mation. ences: onneau G et al. (299) Radiology; 21
075-1080. 4. Wang
emodynamic P
1Nat
with pulmonary huch as short and ray decreased toleranhe five categories
ging (PC-MRI) is aynamic parameterterial distensibility
y hypertension (PPsure waveform, ha
w ( ) during a stance (PVR) [2].
s: The study popuo) and 12 normal 39 9 y/o). PC-Mngen, Germany) uH sequence (TR/Tent was acquired, ses were obtained
y artery (RPA) andsection of above ved to phase imagrs were calculatedtion time ( )),ection (max. ⁄ed to comprehendH patients. the calculated hemnormal subjects The values of ma), respectively. Th4, significantly gr). However, in ou
between two mic parameters fined ratio were st RPA and LPA. Agroups. usions: Hemodynat measured with irs were evaluated ulmonary artery is
might be shly larger, suggestinatio, defined by (mpatients showed h
her pressure in theompliance of aortuishable in our prH patients includey, it is necessary totreatment phases. mance to differentameters, such as
2004). J. Am. Coll.12 : 896-902. 3. T
g JJ et al. (2003) Am
Parameters of
tional Tsing Hua U
hypertension (PH)apid breaths, dizzince of exercise anof PH. Before thea convenient methrs of patients wiy, measured by noPH) and volunteeras been used to descardiac cycle [4].In this study, we a
ulation consisted osubjects without hRI was performedusing the torso c
TE=22/4.8ms, flip sampling 90% of tby using PC-MR
d left pulmonary avessels were selecges for calculationd: , the time fr acceleration volu
), and the ratiod the significance
modynamic results were 94.7 27.0
ax. ⁄ of two he mean value of treater than that ob
ur preliminary resugroups were not sof two groups.
statistically signifiAs for and
namic indices estiinvasive catheterizto non-invasivelymuch higher, the
hortened (Fig. 1(a)ng that the ascendmax. ⁄ )/ higher ratio, sugge
eir pulmonary sysic artery [4]. Horeliminary results ed in this study, tho recruit a larger p In conclusion,
tiation PAH patienPVR, can be inc
. Cardiol. 43 (12 STardivon AA et am J Physiol Heart
Patients with
Hung-Hsuan W
University, Hsinch
) usually present iness, faintness, annd heart failure [1 treatment of PAH
hod for diagnosis. Ith PH have beenon-invasive PC-Mrs (p<0.05) [3]. Wscribe the reservoi Moreover, it hasaim to acquire
of 13 PAH patienhistory of pulmonad on a 1.5T clinicoil with prospecangle=15°) with 1
the cardiac cycle.RI at main pulmonartery (LPA). The cted manually on n of flow velocitrom the onset of fume ( ), maximo of max. ⁄e of the differenc
of MPA. The ms and 132.1groups were 6.40the defined ratio i
btained from normults, the differencestatistically signifiThe parameters
icant between two, there was no
imated by non-invzation methods [2]y differentiate PAHcardiac output mi
)). As shown in Fiding slope of flow
with a unit of secesting that PAH pa
tem. In previousowever, the differe
(Fig. 1(e)). Becahe index of
population of PAHseveral hemodyn
nts from normal gcluded to provide
Suppl S): 5S–12S.al. (1994) Am J Rt Circ Physiol 284:
Pulmonary A
Wang1, and Hsu-Hs
u, Taiwan, 2Nation
an increase in blnd so on, are exac]. The subjects in
H-related diseases, In previous study,n proved with hi
MRI and invasive cWindkessel volume
ir in aortic artery ins been demonstrat
and other hemo
nts (male:6; ary disease ical imager ctive ECG 150 cm/sec Magnitude nary artery regions of magnitude
ty. Several flow to the mal change
to . ce between
of MPA 14.0 ms,
0 3.17 and in patients’
mal subjects es of values cant. Table of ,
o groups at significant
vasive PC-MRI w]. In this study, sevH from normal groight be reduced duig. 1(b), max. rate is higher in P
c-2, implied a physatients’ hearts supp
s study, has bnce of betw
ause of the varietymay not be robus
H patients and to grnamic parametersgroups. In the fute more hemodyna
2. Elie MousseauRespir Crit Care M: H1358–H1368
Arterial Hyper
sia Peng2
nal Tsing Hua Un
lood pressure in cerbated while doincluded in this stu clinicians may ha, non-invasive PC-igh correlation cocatheterization mee ( ), a quantifin animal experimeted that some indiodynamic paramete
were veral roup. ue to ⁄ PAH sical plied
been ween y of st at roup can
ture, amic
ux et Med.
Table1. He
Ratio = NS:no st
rtension by M
iversity, Taiwan
pulmonary arterieing exercise. Pulmudy are patients wave to evaluate pat-MRI has been usoefficients. The hethods, were signied parameter of went [4]. It is calculices derived by Pers to investigate d
emodynamic param
. ⁄ ⁄tatistical significan
MR Phase-Con
es, pulmonary vemonary hypertensiowith pulmonary arttients’ severity at ed to provide relia
hemodynamic parnificantly differenwindkessel effect, lated by integratingC-MRI were highdifferences betwee
meters of subjects
; p-value:Stunce
Fig.1. hemodyparametnormalPAH paparametmax.ratio)significa(d,e) fail to groups.
trast Imaging
ins, or pulmonaryon can be a severeterial hypertensionfirst. Non-invasiveable hemodynamicrameters includingnt between patient
accounted for theg the measuremen
hly correlated withen normal subjects
s
dent’s t-test
Comparing ynamic ters between
subjects and atients. (a-c) Theters ( , ⁄ , defined of MPA are
antly different. and
differentiate two
g
y e n e c g s e
nt h s
1198Proc. Intl. Soc. Mag. Reson. Med. 20 (2012)