Paraxial and Intermediate Mesoderm• Formation of Somites• Muscle and bone formation• Intermediate mesoderm: Kidney formation
Trunk Mesoderm
Mesoderm fate during Gastrulation/Neurulation
Somite Formation• Periodicity• Fissure formation• Epithelialization• specification
Somite Formation: Periodicity• Notch and Wnt Signaling pathways• In chick embryos, new somite every 90 min.
Somite Formation: Periodicity
Somite Formation: Notch Signaling
Somite Formation: Notch Signaling
Somite Formation: Separation
Epithelialization of Somites• Ectodermal Signal: MET• Cdc42 downregulated; N-cadherin upregulated
Somite specification
Somite Differentiation
Somite Differentiation
Specification Patterning of Somites
Building muscle
Building Bone• Neural Crest Cells- Intramembranous ossification• Endochondrial ossification
Vertebrae Formation
Dorsal Aorta Formation
The Syndetome: Tendon Formation
Intermediate Mesoderm: Kidney Formation
Kidney Formation• Induction between Paraxial and Intermediate Mesoderm.
Kidney Formation: Reciprocal Induction
GDNF and Kidney formation
Who else? Wnt!
Development of Bladder and ducts