PHARMACOLOGY OF CANNABINOID RECEPTORS
PRESENTED BY RAJEEV MISHRA 2ND SEM M-PHARMACY PHARMACOLOGY
Cannabinoids are a group of chemicals which activate the bodyrsquos cannabinoid receptors
There are three general types of cannabinoids
Endogenous cannabinoids produced in the bodies of humans and otheranimals1048766
Herbal cannabinoidspresent in the Cannabis plant
Synthetic cannabinoids similar compounds produced in a laboratory
CANNABINOIDS
Cannabinoid receptors are part of the endocannabinoid system which consists of cannabinoid receptor endogenous cannabinoids (endocannabinoids) and the enzymes that synthesis and degrade endocannabinoids
The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily
Cannabinoid receptors are activated by three major group of ligands endocannabinoids plant cannabinoids lsquolsquosynthetic cannabinoids
All of the endocannabinoids and plant cannabinoids are lipophilic ie fat soluble compounds
Cannabinoid receptors
TYPES OF CANNABINOID RECEPTORS
There are currently two known subtypes termed CB1 and CB2
Several endogenous cannabinoids have been identified and the synthetic and degradative pathways of the endocannabinoids have been partially elucidated
Both CB1 and CB2 receptors belong to the superfamily of G protein-coupled receptors coupling to inhibitory G proteins (Gio)
The CB1 receptor was first cloned as orphan receptor from a rat cDNA library
Mainly expressed in BRAIN (CNS) LIVER LUNGS KIDNEY ON MALE FEMALE REPRODUTIVE SYSTEM
BRAIN region- basal ganglia limbic system hippocampus cerebellum involved with thinking amp memoryattention movement controlIn addition CB1 receptors inhibits presynaptic N- and PQ-type calcium channels and activate inwardly rectifying potassium channels
CB1 RECEPTOR
CB2 receptors are mainly expressed ion T CELSS of immune system on B CELLS on MACROPHAGESon HEMATOPOIETIC CELLS
ALSO expressed on peripheral nerve terminal
IN BRAINexpressed by microglial cells
HAVE function as KERATINOCYTESampplay a role in NOCICEPTION (percepion of pain )
CB2 RECEPTOR
CANNABINOID FROM PLANT
Plant cannabinoids are obtained from plant CANNABISIn species- csativacindica
CANNABIS also known as HEMPAs a drug it usually comes in the form of dried flowers (marijuana) resin (hashish) or various extracts collectively referred to as hash oil
Cannabis has been used by different civilizations for a variety of medical applications such as pain stimulation of appetite nausea fever infections and gynecological disorders
Endogenous cannabinoids
Two families of endogenous cannabinoids are known
Endocannabinoids are eicosanoids acting as agonists for cannabinoid receptors and they occur naturally in the body The first identified was anandamide (arachidonoyl ethanolamide) and the second was 2-AG (2-arachidonoyl glycerol) Additional endocannabinoids include virodhamine (O-arachidonoyl ethanolamine) noladin ether (2-arachidonoyl glyceryl ether) and NADA (N-arachidonoyl dopamine)
The endogenous cannabinoid system amp their signalling
The endogenous cannabinoid system includes cannabinoid receptors their endogenous ligands (endocannabinoids) and enzymes for their synthesis and degradationThere are two main receptor types associated with the endocannabinoid signaling system cannabinoid receptor 1 (CB1) and 2 (CB2) Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine monophosphate within cells Endocannabinoid mediated inhibition of neurotransmission comes in two forms transient and long lasting
long-term depression (LTD) LONG LASTING
TransientDSI(depolarization-induced suppression of inhibition) or DSE (depolarization-induced suppression of excitation)
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
Cannabinoids are a group of chemicals which activate the bodyrsquos cannabinoid receptors
There are three general types of cannabinoids
Endogenous cannabinoids produced in the bodies of humans and otheranimals1048766
Herbal cannabinoidspresent in the Cannabis plant
Synthetic cannabinoids similar compounds produced in a laboratory
CANNABINOIDS
Cannabinoid receptors are part of the endocannabinoid system which consists of cannabinoid receptor endogenous cannabinoids (endocannabinoids) and the enzymes that synthesis and degrade endocannabinoids
The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily
Cannabinoid receptors are activated by three major group of ligands endocannabinoids plant cannabinoids lsquolsquosynthetic cannabinoids
All of the endocannabinoids and plant cannabinoids are lipophilic ie fat soluble compounds
Cannabinoid receptors
TYPES OF CANNABINOID RECEPTORS
There are currently two known subtypes termed CB1 and CB2
Several endogenous cannabinoids have been identified and the synthetic and degradative pathways of the endocannabinoids have been partially elucidated
Both CB1 and CB2 receptors belong to the superfamily of G protein-coupled receptors coupling to inhibitory G proteins (Gio)
The CB1 receptor was first cloned as orphan receptor from a rat cDNA library
Mainly expressed in BRAIN (CNS) LIVER LUNGS KIDNEY ON MALE FEMALE REPRODUTIVE SYSTEM
BRAIN region- basal ganglia limbic system hippocampus cerebellum involved with thinking amp memoryattention movement controlIn addition CB1 receptors inhibits presynaptic N- and PQ-type calcium channels and activate inwardly rectifying potassium channels
CB1 RECEPTOR
CB2 receptors are mainly expressed ion T CELSS of immune system on B CELLS on MACROPHAGESon HEMATOPOIETIC CELLS
ALSO expressed on peripheral nerve terminal
IN BRAINexpressed by microglial cells
HAVE function as KERATINOCYTESampplay a role in NOCICEPTION (percepion of pain )
CB2 RECEPTOR
CANNABINOID FROM PLANT
Plant cannabinoids are obtained from plant CANNABISIn species- csativacindica
CANNABIS also known as HEMPAs a drug it usually comes in the form of dried flowers (marijuana) resin (hashish) or various extracts collectively referred to as hash oil
Cannabis has been used by different civilizations for a variety of medical applications such as pain stimulation of appetite nausea fever infections and gynecological disorders
Endogenous cannabinoids
Two families of endogenous cannabinoids are known
Endocannabinoids are eicosanoids acting as agonists for cannabinoid receptors and they occur naturally in the body The first identified was anandamide (arachidonoyl ethanolamide) and the second was 2-AG (2-arachidonoyl glycerol) Additional endocannabinoids include virodhamine (O-arachidonoyl ethanolamine) noladin ether (2-arachidonoyl glyceryl ether) and NADA (N-arachidonoyl dopamine)
The endogenous cannabinoid system amp their signalling
The endogenous cannabinoid system includes cannabinoid receptors their endogenous ligands (endocannabinoids) and enzymes for their synthesis and degradationThere are two main receptor types associated with the endocannabinoid signaling system cannabinoid receptor 1 (CB1) and 2 (CB2) Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine monophosphate within cells Endocannabinoid mediated inhibition of neurotransmission comes in two forms transient and long lasting
long-term depression (LTD) LONG LASTING
TransientDSI(depolarization-induced suppression of inhibition) or DSE (depolarization-induced suppression of excitation)
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
Cannabinoid receptors are part of the endocannabinoid system which consists of cannabinoid receptor endogenous cannabinoids (endocannabinoids) and the enzymes that synthesis and degrade endocannabinoids
The cannabinoid receptors are a class of cell membrane receptors under the G protein-coupled receptor superfamily
Cannabinoid receptors are activated by three major group of ligands endocannabinoids plant cannabinoids lsquolsquosynthetic cannabinoids
All of the endocannabinoids and plant cannabinoids are lipophilic ie fat soluble compounds
Cannabinoid receptors
TYPES OF CANNABINOID RECEPTORS
There are currently two known subtypes termed CB1 and CB2
Several endogenous cannabinoids have been identified and the synthetic and degradative pathways of the endocannabinoids have been partially elucidated
Both CB1 and CB2 receptors belong to the superfamily of G protein-coupled receptors coupling to inhibitory G proteins (Gio)
The CB1 receptor was first cloned as orphan receptor from a rat cDNA library
Mainly expressed in BRAIN (CNS) LIVER LUNGS KIDNEY ON MALE FEMALE REPRODUTIVE SYSTEM
BRAIN region- basal ganglia limbic system hippocampus cerebellum involved with thinking amp memoryattention movement controlIn addition CB1 receptors inhibits presynaptic N- and PQ-type calcium channels and activate inwardly rectifying potassium channels
CB1 RECEPTOR
CB2 receptors are mainly expressed ion T CELSS of immune system on B CELLS on MACROPHAGESon HEMATOPOIETIC CELLS
ALSO expressed on peripheral nerve terminal
IN BRAINexpressed by microglial cells
HAVE function as KERATINOCYTESampplay a role in NOCICEPTION (percepion of pain )
CB2 RECEPTOR
CANNABINOID FROM PLANT
Plant cannabinoids are obtained from plant CANNABISIn species- csativacindica
CANNABIS also known as HEMPAs a drug it usually comes in the form of dried flowers (marijuana) resin (hashish) or various extracts collectively referred to as hash oil
Cannabis has been used by different civilizations for a variety of medical applications such as pain stimulation of appetite nausea fever infections and gynecological disorders
Endogenous cannabinoids
Two families of endogenous cannabinoids are known
Endocannabinoids are eicosanoids acting as agonists for cannabinoid receptors and they occur naturally in the body The first identified was anandamide (arachidonoyl ethanolamide) and the second was 2-AG (2-arachidonoyl glycerol) Additional endocannabinoids include virodhamine (O-arachidonoyl ethanolamine) noladin ether (2-arachidonoyl glyceryl ether) and NADA (N-arachidonoyl dopamine)
The endogenous cannabinoid system amp their signalling
The endogenous cannabinoid system includes cannabinoid receptors their endogenous ligands (endocannabinoids) and enzymes for their synthesis and degradationThere are two main receptor types associated with the endocannabinoid signaling system cannabinoid receptor 1 (CB1) and 2 (CB2) Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine monophosphate within cells Endocannabinoid mediated inhibition of neurotransmission comes in two forms transient and long lasting
long-term depression (LTD) LONG LASTING
TransientDSI(depolarization-induced suppression of inhibition) or DSE (depolarization-induced suppression of excitation)
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
TYPES OF CANNABINOID RECEPTORS
There are currently two known subtypes termed CB1 and CB2
Several endogenous cannabinoids have been identified and the synthetic and degradative pathways of the endocannabinoids have been partially elucidated
Both CB1 and CB2 receptors belong to the superfamily of G protein-coupled receptors coupling to inhibitory G proteins (Gio)
The CB1 receptor was first cloned as orphan receptor from a rat cDNA library
Mainly expressed in BRAIN (CNS) LIVER LUNGS KIDNEY ON MALE FEMALE REPRODUTIVE SYSTEM
BRAIN region- basal ganglia limbic system hippocampus cerebellum involved with thinking amp memoryattention movement controlIn addition CB1 receptors inhibits presynaptic N- and PQ-type calcium channels and activate inwardly rectifying potassium channels
CB1 RECEPTOR
CB2 receptors are mainly expressed ion T CELSS of immune system on B CELLS on MACROPHAGESon HEMATOPOIETIC CELLS
ALSO expressed on peripheral nerve terminal
IN BRAINexpressed by microglial cells
HAVE function as KERATINOCYTESampplay a role in NOCICEPTION (percepion of pain )
CB2 RECEPTOR
CANNABINOID FROM PLANT
Plant cannabinoids are obtained from plant CANNABISIn species- csativacindica
CANNABIS also known as HEMPAs a drug it usually comes in the form of dried flowers (marijuana) resin (hashish) or various extracts collectively referred to as hash oil
Cannabis has been used by different civilizations for a variety of medical applications such as pain stimulation of appetite nausea fever infections and gynecological disorders
Endogenous cannabinoids
Two families of endogenous cannabinoids are known
Endocannabinoids are eicosanoids acting as agonists for cannabinoid receptors and they occur naturally in the body The first identified was anandamide (arachidonoyl ethanolamide) and the second was 2-AG (2-arachidonoyl glycerol) Additional endocannabinoids include virodhamine (O-arachidonoyl ethanolamine) noladin ether (2-arachidonoyl glyceryl ether) and NADA (N-arachidonoyl dopamine)
The endogenous cannabinoid system amp their signalling
The endogenous cannabinoid system includes cannabinoid receptors their endogenous ligands (endocannabinoids) and enzymes for their synthesis and degradationThere are two main receptor types associated with the endocannabinoid signaling system cannabinoid receptor 1 (CB1) and 2 (CB2) Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine monophosphate within cells Endocannabinoid mediated inhibition of neurotransmission comes in two forms transient and long lasting
long-term depression (LTD) LONG LASTING
TransientDSI(depolarization-induced suppression of inhibition) or DSE (depolarization-induced suppression of excitation)
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
The CB1 receptor was first cloned as orphan receptor from a rat cDNA library
Mainly expressed in BRAIN (CNS) LIVER LUNGS KIDNEY ON MALE FEMALE REPRODUTIVE SYSTEM
BRAIN region- basal ganglia limbic system hippocampus cerebellum involved with thinking amp memoryattention movement controlIn addition CB1 receptors inhibits presynaptic N- and PQ-type calcium channels and activate inwardly rectifying potassium channels
CB1 RECEPTOR
CB2 receptors are mainly expressed ion T CELSS of immune system on B CELLS on MACROPHAGESon HEMATOPOIETIC CELLS
ALSO expressed on peripheral nerve terminal
IN BRAINexpressed by microglial cells
HAVE function as KERATINOCYTESampplay a role in NOCICEPTION (percepion of pain )
CB2 RECEPTOR
CANNABINOID FROM PLANT
Plant cannabinoids are obtained from plant CANNABISIn species- csativacindica
CANNABIS also known as HEMPAs a drug it usually comes in the form of dried flowers (marijuana) resin (hashish) or various extracts collectively referred to as hash oil
Cannabis has been used by different civilizations for a variety of medical applications such as pain stimulation of appetite nausea fever infections and gynecological disorders
Endogenous cannabinoids
Two families of endogenous cannabinoids are known
Endocannabinoids are eicosanoids acting as agonists for cannabinoid receptors and they occur naturally in the body The first identified was anandamide (arachidonoyl ethanolamide) and the second was 2-AG (2-arachidonoyl glycerol) Additional endocannabinoids include virodhamine (O-arachidonoyl ethanolamine) noladin ether (2-arachidonoyl glyceryl ether) and NADA (N-arachidonoyl dopamine)
The endogenous cannabinoid system amp their signalling
The endogenous cannabinoid system includes cannabinoid receptors their endogenous ligands (endocannabinoids) and enzymes for their synthesis and degradationThere are two main receptor types associated with the endocannabinoid signaling system cannabinoid receptor 1 (CB1) and 2 (CB2) Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine monophosphate within cells Endocannabinoid mediated inhibition of neurotransmission comes in two forms transient and long lasting
long-term depression (LTD) LONG LASTING
TransientDSI(depolarization-induced suppression of inhibition) or DSE (depolarization-induced suppression of excitation)
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
CB2 receptors are mainly expressed ion T CELSS of immune system on B CELLS on MACROPHAGESon HEMATOPOIETIC CELLS
ALSO expressed on peripheral nerve terminal
IN BRAINexpressed by microglial cells
HAVE function as KERATINOCYTESampplay a role in NOCICEPTION (percepion of pain )
CB2 RECEPTOR
CANNABINOID FROM PLANT
Plant cannabinoids are obtained from plant CANNABISIn species- csativacindica
CANNABIS also known as HEMPAs a drug it usually comes in the form of dried flowers (marijuana) resin (hashish) or various extracts collectively referred to as hash oil
Cannabis has been used by different civilizations for a variety of medical applications such as pain stimulation of appetite nausea fever infections and gynecological disorders
Endogenous cannabinoids
Two families of endogenous cannabinoids are known
Endocannabinoids are eicosanoids acting as agonists for cannabinoid receptors and they occur naturally in the body The first identified was anandamide (arachidonoyl ethanolamide) and the second was 2-AG (2-arachidonoyl glycerol) Additional endocannabinoids include virodhamine (O-arachidonoyl ethanolamine) noladin ether (2-arachidonoyl glyceryl ether) and NADA (N-arachidonoyl dopamine)
The endogenous cannabinoid system amp their signalling
The endogenous cannabinoid system includes cannabinoid receptors their endogenous ligands (endocannabinoids) and enzymes for their synthesis and degradationThere are two main receptor types associated with the endocannabinoid signaling system cannabinoid receptor 1 (CB1) and 2 (CB2) Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine monophosphate within cells Endocannabinoid mediated inhibition of neurotransmission comes in two forms transient and long lasting
long-term depression (LTD) LONG LASTING
TransientDSI(depolarization-induced suppression of inhibition) or DSE (depolarization-induced suppression of excitation)
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
CANNABINOID FROM PLANT
Plant cannabinoids are obtained from plant CANNABISIn species- csativacindica
CANNABIS also known as HEMPAs a drug it usually comes in the form of dried flowers (marijuana) resin (hashish) or various extracts collectively referred to as hash oil
Cannabis has been used by different civilizations for a variety of medical applications such as pain stimulation of appetite nausea fever infections and gynecological disorders
Endogenous cannabinoids
Two families of endogenous cannabinoids are known
Endocannabinoids are eicosanoids acting as agonists for cannabinoid receptors and they occur naturally in the body The first identified was anandamide (arachidonoyl ethanolamide) and the second was 2-AG (2-arachidonoyl glycerol) Additional endocannabinoids include virodhamine (O-arachidonoyl ethanolamine) noladin ether (2-arachidonoyl glyceryl ether) and NADA (N-arachidonoyl dopamine)
The endogenous cannabinoid system amp their signalling
The endogenous cannabinoid system includes cannabinoid receptors their endogenous ligands (endocannabinoids) and enzymes for their synthesis and degradationThere are two main receptor types associated with the endocannabinoid signaling system cannabinoid receptor 1 (CB1) and 2 (CB2) Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine monophosphate within cells Endocannabinoid mediated inhibition of neurotransmission comes in two forms transient and long lasting
long-term depression (LTD) LONG LASTING
TransientDSI(depolarization-induced suppression of inhibition) or DSE (depolarization-induced suppression of excitation)
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
Endogenous cannabinoids
Two families of endogenous cannabinoids are known
Endocannabinoids are eicosanoids acting as agonists for cannabinoid receptors and they occur naturally in the body The first identified was anandamide (arachidonoyl ethanolamide) and the second was 2-AG (2-arachidonoyl glycerol) Additional endocannabinoids include virodhamine (O-arachidonoyl ethanolamine) noladin ether (2-arachidonoyl glyceryl ether) and NADA (N-arachidonoyl dopamine)
The endogenous cannabinoid system amp their signalling
The endogenous cannabinoid system includes cannabinoid receptors their endogenous ligands (endocannabinoids) and enzymes for their synthesis and degradationThere are two main receptor types associated with the endocannabinoid signaling system cannabinoid receptor 1 (CB1) and 2 (CB2) Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine monophosphate within cells Endocannabinoid mediated inhibition of neurotransmission comes in two forms transient and long lasting
long-term depression (LTD) LONG LASTING
TransientDSI(depolarization-induced suppression of inhibition) or DSE (depolarization-induced suppression of excitation)
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
The endogenous cannabinoid system amp their signalling
The endogenous cannabinoid system includes cannabinoid receptors their endogenous ligands (endocannabinoids) and enzymes for their synthesis and degradationThere are two main receptor types associated with the endocannabinoid signaling system cannabinoid receptor 1 (CB1) and 2 (CB2) Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine monophosphate within cells Endocannabinoid mediated inhibition of neurotransmission comes in two forms transient and long lasting
long-term depression (LTD) LONG LASTING
TransientDSI(depolarization-induced suppression of inhibition) or DSE (depolarization-induced suppression of excitation)
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
CB1 Receptor agonist
Endocannbinoids are agonist for cb1 receptorsANANDAMIDE amp 2-AG are two endocannabinoid located in brain
Anandamide ndash 1st endogenous cannbinoid from porcine brainHave functions mesentric vasodilation in vivo amp PSHYCOACTIVE EFFECThave low efficacy (agonist action ) at cb1 receptor similar to delta9 THC
Degrades by FAAH (fatty acid amino hydrolase )
2mdashAG (2-ARACIDNOYL GLYCEROL ) 2ND AFTER ANANDAMIDEmajor highly effective attenuates the early phase amp late phase behaviour amp produce endothelium induced hypotension
Degrades by MAG LIPASE (mono glycerol lipase )
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
CB2R selectiveagonists
CB2 receptor agonists have potentially useful effects in a number of models of inflammatory and neuropathic pain possibly involving the release of endogenous opioids and can inhibit growth of CB2-receptor-expressing gliomain vivo
Cb2 agonist useful in various model for osteoporosis artherosclerosis
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
clinical studies suggest that CB1 antagonists have significant metabolic effects that extend beyond decreasing caloric intake
Rimonabant also known as SR141716 or Acompliareg was the first CB1 antagonist reported
It is a diarylpyrazole with nanomolar affinity for CB1 receptors and little affinity for the CB2 receptors
Many congeners of rimonabant have been synthesized and an SAR developed
CB1 Receptor Antagonists
Cb1 antagonist useful in smoking cessation appetite suppressent decrease food consumption obesity treatment
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
Cannabinoids potential anticancer agents
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
It is commonly assumed - although not rigorously proven that endocannabinoid action is terminated in part by their uptake into cells
This putative mechanism appears similar for anandamide and 2-AG with some mild difference
However whether endocannabinoid transport occurs through a specific transporter or by nonspecific means is still the subject of some debate
The initial pharmacological probe used to study the putative endocannabinoid membrane transporter (EMT) AM404 inhibited uptake but it also interacted with CB1 receptors and activated VR1 channels at higher concentrations
Endocannabinoid Transport Inhibitors
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
FAAH seems to be the major degradative enzyme for anandamide and related amides in vivoThus drugs that selectively inhibit FAAH would increase N-acylethanolamine levels without affecting those of 2-AGEg URB532 URB597 the reversible alpha-ketoheterocycle FAAH inhibitors are OL92
Fatty Acid Amino Hydrolase (FAAH )
Therapeutic Promises
Thankuuuuuuu
uu
Therapeutic Promises
Thankuuuuuuu
uu
Thankuuuuuuu
uu