RAS oncogene
Research goals
Outline
RAS oncogene
Molecular characterization
Mammalian counterpart
Point mutations
Transforming oncogene
Biochemical properties
Ras family
Ras GDP-GTP Cycle
Ras membrane localization
Ras signaling network
Ras mutations
Mutation spectrum
GTP hydrolysis
Oncogenic driver
Neoplastic transformation
Ras signaling
Ras membrane association
Ras inhibition
Direct inhibition
Kinase inhibitors
MAPK pathway
MAPK pathway
Feedback activation
MEKi combinations
Therapeutic window
Synthetic lethality
Oncogene addiction
Synthetic lethal interactions
Dissecting the contribution
siRNA platform
KRAS addiction
Ras effector and stress response
Single node dependency
Private node dependency
Paired node dependency
Paired node pair dependencies
Private node pair dependency
Gene paralog combinations
Deconvolution
Knockdown
Cell cycle arrest
Autophagy pathways
RAF kinase and autophagy
Co-targeting
MAPK and autophagy
Acknowledgment