The Mechanism of Protein Splicing:
**** the movie ****
Animation by Maurice W. Southworth
As seen in InBase, Francine Perler, Curator
CH2
SH
Cys
Intein
Asn
C-extein
NH
Cys
C
O
N-extein
NH C
O
CH2
SH
CH2
SH
N-extein Cys
Intein C-extein
Asn
C
O
NH
Cys
C
O
NH
CH2
SH
CH2
SH
N-exteinCys
Intein C-extein
Asn
C
O
NH
Cys
C
O
NH
CH2
SH
CH2
SH
N-extein
Cys
Intein C-extein
Asn
C
O
NH
Cys
C
O
NH
CH2
SH
CH2S
N-extein
Cys
Intein C-extein
Asn
C
O
NH
Cys
C
O
NH2
CH2
SH
Intein C-extein
Asn
C
O
NH
Cys
CH2
SH
CH2
SN-extein
Cys
C
O
NH2
Intein
C-extein
Asn
C
O
NH
CH2
SH
CH2
SN-extein
Cys
C
O
NH2
Intein
C-extein
Asn
C
O
NH
CH2
SH
CH2
SN-extein
Cys
C
O
NH2
Intein
C-extein
Asn
C
O
NH
CH2
SH
CH2
SN-extein
Cys
NH2
C
O
CH2
N-extein
Cys
Intein
C-extein
Asn
C
O
CH2
SH
S
C
O
NH
NH2
CH2
N-extein
Cys
Intein
C-extein
Asn
C
O
CH2
SH
S
C
O
NH
NH2
CH2
N-extein
Cys
Intein
C-extein
Asn
C
O
CH2
SH
S
C
NH
O
NH2
CH2
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2S
SH
C
O
NH2
CH2
N-extein
Cys
Intein
C-extein
Asn
C
O
CH2S
SH
C
O
NH2
NH
N-extein
Cys
Intein
C-extein
Asn
C
O
CH2
SC
O
NH2
CH2
SH
NH
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
SC
O
NH2
CH2
SH
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
SH
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
SH
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
SH
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
SH
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
C
NH2
CH2
SHO
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
C
NH2
CH2
SHO
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
C
NH2
CH2
SHO
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
C
NH2
CH2
SHO
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
C
NH2
CH2
SHO
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
CNH2
CH2
SHO
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2
NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
Asn
C
O
NH
CH2
S
C
O
NH2
CH2NH2
CH2
SHC
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
S
C
O
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
Cys
Intein
C-extein
NH2
CH2
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-exteinS
C
O
N-extein
Cys
Intein
C-extein
NH2CH2
S
C
O
NH2
CH2
SHCys
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2CH2
S
C
O
NH2
CH2
SHCys
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
SC
O
NH2
CH2
SHCys
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH2
CH2
SC
O
NH2
CH2
SHCys
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NHCH2
SH
C
O
NH2
CH2
SHCys
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NHCH2
SH
C
O
NH2
CH2
SHCys
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH
CH2
SH
C
O
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH
CH2
SH
C
O
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-extein
Cys
Intein
C-extein
NH
CH2
SH
C
O
NH2
CH2
SH
Cys
Asn
C
O
NHCH2
C
O
N-extein C-extein
NH
CH2
SH
C
O
Cys
Cys
Intein
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein C-extein
NH
CH2
SH
C
O
Cys
Cys
Intein
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein C-extein
NH
SH
C
O
Cys
Cys
Intein
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
CH2
N-extein C-extein
NH
CH2
SH
C
O
Cys
Cys
Intein
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein C-extein
NH
CH2
SH
C
O
Cys
Cys
Intein
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein C-extein
NH
CH2
SH
C
O
Cys
Cys
Intein
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein C-extein
NH
CH2
SH
C
O
Cys
Cys
Intein
NH2
CH2
SH
Asn
C
O
NHCH2
C
O
N-extein C-extein
NH
CH2
SH
C
O
Cys
Cys
Intein
NH2
CH2
SH
Asn
C
O
NHCH2
C
O