vet.osu.edu/biosciences
BIOS
In the Department of Veterinary Bioscience, we discover the mechanisms of disease. We use this knowledge to educate others and to develop and utilize tools for disease diagnosis, treatment, and intervention to improve the health of animals and humans. In the process of educating others, several members of VBS were recently recognized for their teaching excellence!
Dr. Li Wu is shown receiving the Charles C. Capen Teaching Excellence Award for Graduate Education from Dean Lonnie King. This award honors faculty who excel in their roles as advisors and mentors for Master of Science and Doctor of Philosophy candidates, as participants in departmental graduate programs, or as resource persons for the graduate students of the College.
Dr. Mary Jo Burkhard is shown receiving the Class of 2018 Excellence in Teaching Award from Kristen Bartholomew (Class President). Excellence in Teaching awardees are selected by students in the professional veterinary medical education program based on their character, the caliber of their instruction and teaching ability, and their responsiveness to needs of the students.
Dr. Maggie Shoemaker (1st year PhD / anatomic pathology resident) is awarded the SCAVMA Outstanding Teacher Award for Resident/Graduate Teaching Associates by Lyle Simpson (SCAVMA President). This award recognizes teaching ability, knowledge in their area of expertise, responsiveness to the needs of students, and dedication to the College and the profession.
Our Educational Mission
It is not the strongest of the species that survive, nor the most intelligent, but the one most responsive to change. – Charles Darwin
Dr. Salvador (Sal) Butera was recognized as a Distinguished Alumnus of the College of Veterinary Medicine at this year’s Oath and Hooding Ceremony. Sal is currently Chief Science Officer at the Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery at the Scripps Research Institute. His career path has been inherently impactful – he has utilized an extensive background of laboratory expertise, senior-‐level management experience, and knowledge of US Government health-‐science programs to advance human and animal disease prevention with local benefit and global impact. Dr. Butera completed a dual degree program at The Ohio State University receiving his DVM and MS in 1985. He followed this with a PhD at Colorado State University and then entered a 22 year career at CDC where he rose from Staff Research Fellow to Virology Section Chief to the Associate Director for Laboratory Science, Office of the Director, National Center for HIV/AIDS, Viral Hepatitis, STD and TB Prevention. Sal then transitioned to The Scripps Research Institute in La Jolla California, where he now serves as Director of Scientific Support for the Neutralizing Antibody Center, which is part of the International AIDS Vaccine Initiative. He and his group have secured funding from the NIH to establish the Center for HIV/AIDS Vaccine Immunology and Immunogen Discovery -‐ whose goal is to develop an HIV preventative vaccine. Sal has an extensive record of peer-‐reviewed scholarship, book chapters, and invited presentations, as well as editorial, advisory, and review panels. However, most importantly, by embracing leadership roles at the CDC and The Scripps Research Institute, Dr. Butera demonstrates the power and value of a veterinary medical education to the broader biomedical community.
Distinguished alum Salvador Butera
Shannon Binkley Title: Program Assistant Years of Service: 1 year Where do you work? Front Office of Goss Lab Recent contribution to the department: Working with Dr. Cianciolo and Texas A&M University to coordinate shipping for The International Veterinary Renal Pathology Service. We’ve helped practices in Australia, South Korea, the UK, and Canada. Best Part about working in Biosciences: Listening to researchers talking about their projects and actually understanding some of it now (from being surrounded by it for a year). And, getting to – hopefully! – maybe see the inside of a squid someday.
Contributing to our service and outreach mission
It is what we make of what we have, not what we are given, that separates one person from another.
- Nelson Mandela
Rosol Selected as HBA Mentor for Personal Branding Dr. Rosol has been selected as the only male mentor for the Healthcare Businesswomen’s Association (HBA) in-depth program on personal branding. Rosol will have 4 mentees selected by HBA and they will complete their program that includes two meetings a month with a market-
ready brand during a graduation ceremony in November. The program follows the book, ‘Branding Pays: The Five-Step System to Reinvent Your Personal Brand’ by branding expert, Karen Kang. www.hbanet.org
Anne Saulsbery Title: Lead Histology Technician (although we are all pretty self-‐sufficient!) Years of Service: 15 years
Where do you work? The Histology Lab Recent contribution to the department: I enjoy adding to my knowledge of special stains the renal panel of stains that I had to acquire when Dr. Cianciolo came on board with the renal pathology service. Best Part about working in Biosciences: The best part of working in Biosciences for me is meeting and learning from all the researchers and graduate students that come though the histology lab.
Trainee Awards – Kudos!
Dreams are extremely important. You can’t do it unless you can imagine it. - George Lucas
Congratulations current & alumni trainees for successful completion of Phase I of the ACVP Certifying Exam!
Nadine Bowden Sarah Chaney Elizabeth Clark Laurie Milward
CVM Research Day Immunology & Infectious Diseases *
Tara Martin
Identification of cGAMP as an effective adjuvant for induction of mucosal IgA via sublingual immunization
Mentor: Dr. Prosper Boyaka
* Sponsored by the Public Health Preparedness for Infectious Diseases Program
CVM Research Day Molecular & Cellular Biology
Dr. Lauren Himmel
Suppression of breast cancer stem cells in the MMTV-Her2/neu mouse model by the hdac inhibitor AR-42
Mentor: Dr. Ching-Shih Chen
Dr. Michael Martinez
Received the Ohio State Excellence in Pathology and the ACVP Excellence in Veterinary Pathology Awards. He will join our combined anatomic residency / PhD program in June!
Feifei Wang Hayes Graduate Research Forum
2nd Place, Oral Presentation
Effect of phosphorylation of mouse SAMHD1 on restriction of HIV-‐1 and murine leukemia virus infections
Mentor: Dr. Li Wu
EunSoo Kim
Chronic ingestion of low doses of cadmium alters the gut microbiome and immune homeostasis to enhance allergic sensitization
Selected for oral presentation & travel award at the American Association of Immunologists meeting
Mentors: Drs. Estelle Cormet-‐Boyaka and Prosper Boyaka
Impact starts with discovery!
Your success in life isn’t based on your ability to simply change. It is based on your ability to change faster than your competition.
– Mark Sanborn
Engineering protease-‐resistant A/B foldamer peptides for broad spectrum antivirals. Stefan Niewiesk; Weill Cornell Medical College.
Mechanisms underlying influenza-‐induced CF exacerbations. Ian Davis; Cystic Fibrosis Foundation.
Dissecting the role of miR-‐9 in normal and malignant mast cell biology. Joelle Fenger (Mentors: Cheryl London, Guido Marcucci); National Institutes of Health, KO2.
Accelerator Award Congratulations to Drs. Yasuko Rikihisa and Ian
Davis, their internal team, Drs. Jean Schelhorn, Kate Hayes-‐Ozello, Tom Rosol, and Melissa Kelly, and external partners Dr. David Ralph and Mr. John Steele on winning an Ohio State University
Accelerator Award for their proposal:
Harnessing Nature’s Tick to Deliver Drugs
This was the first round of Accelerator Awards granted at The Ohio State University. The primary goal of the new Accelerator Awards is to provide Ohio State researchers with awards up to $50,000 to develop and validate inventions, software, and technologies and to make early inventions more marketable to potential licensing and/or business partners.
People think focus means saying yes to the thing you’ve got to focus on. But that’s not what it means at all. It means saying no to the hundred other good ideas that there are. You have to pick carefully. – Steve Jobs
Publication spotlight: Cigarette smoke damages channels in airway cells that are critical for mucous clearance
Over 90% of patients who develop chronic obstructive pulmonary disease (COPD) are or were smokers and cigarette smoke has been shown to interfere with the function of airway cell channels that are critical for airway cells to remove mucous and other material from the lungs. In this study, the lab of Dr. Estelle Cormet-‐Boyaka found that cigarette smoke activates a pathway (MAPK/ERK) which is responsible for communication between the airway cell’s nucleus and the channel on the surface. Activation of this pathway leads to increased destruction of the airway channel – a key marker associated with reduced clearance of mucous, bronchitis, and obstructive airway disease in people. Importantly, they found that blocking the MAPK/ERK pathway, prevented the destruction of the airway channel – providing potential new treatments for patients with COPD.
Biochimica et Biophysica Acta http://www.ncbi.nlm.nih.gov/pubmed/25697727
Publication spotlight: Newly characterized pig virus causes major economic impact
In 2014, a new virus emerged in pigs in the Midwest and rapidly spread across North America resulting in major economic losses. Although having similarity to other major diseases of pigs (transmissible gastroenteritis and epidemic diarrhea), veterinarians and researchers were able to identify a novel virus (porcine deltacoronovirus) as causing the disease. The labs of Drs. Jianrong Li, Steve Krakowka, and Mike Oglesbee teamed up to study this virus. They analyzed the virus’s genetic structure found it to be similar to coronoviruses of Asian leopard cats and Chinese ferret-‐badgers. They also tested the virus and compared it to other coronoviruses of pigs to better understand the disease it causes, the organs it affects, how it is transmitted and infects other pigs, and how to test for the infection. They show that the new virus causes severe diarrhea and vomiting in piglets, replicates strongly in the gut but also blood and multiple organs throughout the body. Furthermore, the virus was found to be highly infectious and could persist in pigs for a long period of time – making it a challenge to clear from a swine facility.
MBio http://www.ncbi.nlm.nih.gov/pubmed/25759498
Have something to contribute to BIOS? An interesting update? Someone we should highlight? A good quote or kudos you’d like to share? Please contact Robyn Luce at [email protected]
Ideas are cheap – making something of them is difficult. - Anne Sigismund Huff
From our pathology and shared resource groups Comparative Pathology & Mouse Phenotyping Shared Resource • Bolon, B (Editor). Pathology of the Developing Mouse; a systematic approach. CRC Press • Coble DJ, Shoemaker M, Harrington B, Dardenne AD, Bolon B. Histiocytic Sarcoma and Bilateral
Facial Vein Thrombosis in a Siberian Hamster (Phodopus sungorus). Comp Med http://www.ncbi.nlm.nih.gov/pubmed/25926398
• Gressel KL, Duncan FJ, Oberyszyn TM, La Perle KM, Everts HB. Endogenous Retinoic Acid Required to Maintain the Epidermis Following Ultraviolet Light Exposure in SKH-1 Hairless Mice. Photochem Photobiol http://www.ncbi.nlm.nih.gov/pubmed/25715879
International Veterinary Renal Pathology Service • Cianciolo RE, Mohr FC, Aresu L, Brown CA, James C, Jansen JH, Spangler WL, van der Lugt JJ,
Kass PH, Brovida C, Cowgill LD, Heiene R, Polzin DJ, Syme H, Vaden SL, Dongen AM, Lees GE. World Small Animal Veterinary Association Renal Pathology Initiative: Classification of Glomerular Diseases in Dogs. Vet Pathol http://www.ncbi.nlm.nih.gov/pubmed/25957358
• Holm LP, Hawkins I, Robin C, Newton RJ, Jepson R, Stanzani G, McMahon LA, Pesavento P, Carr T, Cogan T, Couto CG, Cianciolo R, Walker DJ. Cutaneous and renal glomerular vasculopathy as a cause of acute kidney injury in dogs in the UK. Vet Rec http://www.ncbi.nlm.nih.gov/pubmed/25802439
Pathology • Pieczarka EM, Russell DS, Santangelo KS, Aeffner F, Burkhard MJ. Osseous metaplasia within a
canine insulinoma. Vet Clin Pathol http://www.ncbi.nlm.nih.gov/pubmed/24446791
From our research and clinical trial groups
Boyaka lab • Xu X, Balsiger R, Tyrrell J, Boyaka PN, Tarran R, Cormet-Boyaka E. Cigarette smoke exposure
reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR. Biochim Biophys Acta http://www.ncbi.nlm.nih.gov/pubmed/25697727
Cormet-Boyaka lab • Abdelaziz DH, Khalil H, Cormet-Boyaka E, Amer AO. The cooperation between the autophagy
machinery and the inflammasome to implement an appropriate innate immune response: do they regulate each other? Immunol Rev http://www.ncbi.nlm.nih.gov/pubmed/25879294
• Gorr MW, Youtz DJ, Eichenseer CM, Smith KE, Nelin TD, Cormet-Boyaka E, Wold LE. In vitro particulate matter exposure causes direct and lung-mediated indirect effects on cardiomyocyte function. Am J Physiol Heart Circ Physiol http://www.ncbi.nlm.nih.gov/pubmed/25957217
• Qian Z, Xu X, Amacher JF, Madden DR, Cormet-Boyaka E, Pei D. Intracellular Delivery of Peptidyl Ligands by Reversible Cyclization: Discovery of a PDZ Domain Inhibitor that Rescues CFTR Activity. Angew Chem Int Ed Engl http://www.ncbi.nlm.nih.gov/pubmed/25785567
• Xu X, Balsiger R, Tyrrell J, Boyaka PN, Tarran R, Cormet-Boyaka E. Cigarette smoke exposure reveals a novel role for the MEK/ERK1/2 MAPK pathway in regulation of CFTR. Biochim Biophys Acta http://www.ncbi.nlm.nih.gov/pubmed/25697727
Sharing new knowledge
A good head and a good heart are always a formidable combination. But when you add to that a literate tongue or pen, then you have something very special.
- Nelson Mandela
Davis lab • Woods PS, Tazi MF, Chesarino NM, Amer AO, Davis IC. TGF-β-induced IL-6 prevents development of
acute lung injury in influenza A virus-infected F508del CFTR-heterozygous mice. Am J Physiol Lung Cell Mol Physiol http://www.ncbi.nlm.nih.gov/pubmed/25840995
Hamlin lab • Authier S, Curtis MJ, Soloviev M, Redfern WS, Kallman MJ, Hamlin RL, Leishman DJ, Valentin JP,
Koerner JE, Vargas HM, Botchway A, Correll K, Pugsley MK. The Diplomate in Safety Pharmacology (DSP) certification scheme. J Pharmacol Toxicol Methods http://www.ncbi.nlm.nih.gov/pubmed/25959882
Krakowka lab • Ma Y, Zhang Y, Liang X, Lou F, Oglesbee M, Krakowka S, Li J. Origin, evolution, and virulence of
porcine deltacoronaviruses in the United States. MBio http://www.ncbi.nlm.nih.gov/pubmed/25759498 Li lab • Cai H, Zhang Y, Ma Y, Sun J, Liang X, Li J. Zinc binding activity of human metapneumovirus M2-1
protein is indispensable for viral replication and pathogenesis in vivo. J Virol http://www.ncbi.nlm.nih.gov/pubmed/25855728
• Liu C, Tang J, Ma Y, Liang X, Yang Y, Peng G, Qi Q, Jiang S, Li J, Du L, Li F. Receptor usage and cell entry of porcine epidemic diarrhea coronavirus. J Virol http://www.ncbi.nlm.nih.gov/pubmed/25787280
• DiCaprio E, Purgianto A, Li J. The Effect of Abiotic and Biotic Stress on the Internalization and Dissemination of Human Norovirus Surrogates in Growing Romaine Lettuce. Appl Environ Microbio http://www.ncbi.nlm.nih.gov/pubmed/25956773
• Lou F, Neetoo H, Chen H, Li J. High hydrostatic pressure processing: a promising nonthermal technology to inactivate viruses in high-risk foods. Annu Rev Food Sci Technol http://www.ncbi.nlm.nih.gov/pubmed/25884283
• Ma Y, Zhang Y, Liang X, Lou F, Oglesbee M, Krakowka S, Li J. Origin, evolution, and virulence of porcine deltacoronaviruses in the United States. MBio http://www.ncbi.nlm.nih.gov/pubmed/25759498
London lab • London CA, Gardner HL, Mathie T, Stingle N, Portela R, Pennell ML, Clifford CA, Rosenberg MP, Vail
DM, Williams LE, Cronin KL, Wilson-Robles H, Borgatti A, Henry CJ, Bailey DB, Locke J, Northrup NC, Crawford-Jakubiak M, Gill VL, Klein MK, Ruslander DM, Thamm DH, Phillips B, Post G. Impact of Toceranib/Piroxicam/Cyclophosphamide Maintenance Therapy on Outcome of Dogs with Appendicular Osteosarcoma following Amputation and Carboplatin Chemotherapy: A Multi-Institutional Study. PLoS One http://www.ncbi.nlm.nih.gov/pubmed/25923466
Oglesbee lab • Ma Y, Zhang Y, Liang X, Lou F, Oglesbee M, Krakowka S, Li J. Origin, evolution, and virulence of
porcine deltacoronaviruses in the United States. MBio http://www.ncbi.nlm.nih.gov/pubmed/25759498 Rikihisa lab • Cheng Z, Lin M, Rikihisa Y. Erratum for Cheng et al., Ehrlichia chaffeensis proliferation begins with
NtrY/NtrX and PutA/GlnA upregulation and CtrA degradation induced by proline and glutamine uptake. MBio http://www.ncbi.nlm.nih.gov/pubmed/25784699
Impact through scholarship
Rosol lab • Byrd RA, Sorden SD, Ryan T, Pienkowski T, LaRock R, Quander R, Wijsman JA, Smith HW,
Blackbourne JL, Rosol TJ, Long GG, Martin JA, Vahle JL. Chronic Toxicity and Carcinogenicity Studies of the Long-Acting GLP-1 Receptor Agonist Dulaglutide in Rodents. Endocrinology http://www.ncbi.nlm.nih.gov/pubmed/25860029
• Parviainen S, Autio K, Vähä-Koskela M, Guse K, Pesonen S, Rosol TJ, Zhao F, Hemminki A. Incomplete but infectious vaccinia virions are produced in the absence of oncolysis in feline SCCF1 cells. PLoS One http://www.ncbi.nlm.nih.gov/pubmed/25799430
• Vahle JL, Byrd RA, Blackbourne JL, Martin JA, Sorden SD, Ryan T, Pienkowski T, Wijsman JA, Smith HW, Rosol TJ. Effects of Dulaglutide on Thyroid C-Cells and Serum Calcitonin in Male Monkeys. Endocrinology http://www.ncbi.nlm.nih.gov/pubmed/25860028
Wu lab • de Silva S, St. Gelais C, Nagaraja T, and Wu L. Counteraction of SAMHD1 by Vpx. In Hope T,
Richman D, Stevenson M. (Ed.) Encyclopedia of AIDS • St Gelais C, Roger J, Wu L. Non-POU Domain-Containing Octamer-Binding Protein Negatively
Regulates HIV-1 Infection in CD4+ T Cells. AIDS Res Hum Retroviruses http://www.ncbi.nlm.nih.gov/pubmed/25769457
• Wong HK, de Silva S, Mishra A, Wu L, and Porcu P. Cutaneous T Cell Lymphoma: Mycosis Fungoides and Sézary Syndrome. In Lu, Q., Chang CC, and Richardson BC (Eds) Epigenetics & Dermatology
Scholarship and Excellence
Noteworthy news!
Drs. Jean Schelhorn and Tom Rosol, with Dr. Joan Herbers and members of the NSF funded CEOS (Comprehensive Equity at Ohio State) project, were part of the Organizing Committee for the National Summit on Innovation & Entrepreneurship – A Roadmap for Inclusion held April 30, 2015 in Washington DC. This partnership between the Association for Women in Science (AWIS) and Ohio State, was designed to bring together experts in innovation and entrepreneurship from industry, academia, and government to develop a roadmap for engaging women as well as men in STEM (science, technology, engineering, and mathematics) entrepreneurship.
Science is simply common sense at its best, that is, rigidly accurate in observation and merciless to fallacy in logic. - Thomas Henry Huxley