Bradley W. Christian, McLennan Community College© 2016 Pearson Education, Inc.

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Chapter 20: Antimicrobial Drugs

History Antimicrobials Mode of Action

Today and the FutureResistance

FINAL ROUND

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Topic 1: History $100 Question

The birth of modern chemotherapy is creditedto the efforts of

a. Alexander Fleming.b. Paul Ehrlich.c. Robert Koch.d. Louis Pasteur.

ANSWER

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Topic 1: History $100 Answer

The birth of modern chemotherapy is creditedto the efforts of

a. Alexander Fleming.b. Paul Ehrlich.c. Robert Koch.d. Louis Pasteur.

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Topic 1: History $200 Question

In 1928, who observed that the growth of bacteriawas inhibited on a Petri plate contaminated by amold?

a. Alexander Flemingb. Paul Ehrlichc. Robert Kochd. Louis Pasteur

ANSWER

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Topic 1: History $200 Answer

In 1928, who observed that the growth of bacteriawas inhibited on a Petri plate contaminated by amold?

a. Alexander Flemingb. Paul Ehrlichc. Robert Kochd. Louis Pasteur

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Topic 1: History $300 Question

What was the FIRST antibiotic discovered?

a. tetracyclineb. erythromycinc. streptomycind. penicillin

ANSWER

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Topic 1: History $300 Answer

What was the FIRST antibiotic discovered?

a. tetracyclineb. erythromycinc. streptomycind. penicillin

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Topic 1: History $400 Question

In World War II, which of the following made it clear that antimicrobial agents could be effective against systemic bacterial infections?

a. sulfa drugs b. penicillinc. tetracyclined. erythromycin

ANSWER

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Topic 1: History $400 Answer

In World War II, which of the following made it clear that antimicrobial agents could be effective against systemic bacterial infections?

a. sulfa drugs b. penicillinc. tetracyclined. erythromycin

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Topic 1: History $500 Question

More than half of our antibiotics are produced byspecies of

a. Mycobacterium.b. Streptomyces. c. Clostridium.d. Bacillus.

ANSWER

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Topic 1: History $500 Answer

More than half of our antibiotics are produced byspecies of

a. Mycobacterium.b. Streptomyces. c. Clostridium.d. Bacillus.

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Topic 2: Antimicrobials $100 Question

Which of the following are the easiest to treat withantimicrobial agents?

a. virusesb. fungic. bacteria d. protozoa

ANSWER

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Topic 2: Antimicrobials $100 Answer

Which of the following are the easiest to treat withantimicrobial agents?

a. virusesb. fungic. bacteria d. protozoa

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Topic 2: Antimicrobials $200 Question

One disadvantage to using broad-spectrumantibiotics is that they

a. destroy normal microbiota.b. are easily inactivated by the host.c. are extremely toxic.d. target host cells.

ANSWER

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Topic 2: Antimicrobials $200 Answer

One disadvantage to using broad-spectrumantibiotics is that they

a. destroy normal microbiota.b. are easily inactivated by the host.c. are extremely toxic.d. target host cells.

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Topic 2: Antimicrobials $300 Question

Practically ALL antibiotic-producing microbes have a(n) ________ process.

a. toxin-producingb. sporulationc. motilityd. encapsulation

ANSWER

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Topic 2: Antimicrobials $300 Answer

Practically ALL antibiotic-producing microbes have a(n) ________ process.

a. toxin-producingb. sporulationc. motilityd. encapsulation

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Topic 2: Antimicrobials $400 Question

If an antibiotic prevents bacteria from growing, then its action is termed

a. bactericidal.b. selectively toxic.c. bacteriostatic. d. toxic.

ANSWER

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Topic 2: Antimicrobials $400 Answer

If an antibiotic prevents bacteria from growing, then its action is termed

a. bactericidal.b. selectively toxic.c. bacteriostatic. d. toxic.

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Topic 2: Antimicrobials $500 Question

Which of the following antimicrobials has thebroadest spectrum of activity?

a. streptomycinb. isoniazidc. penicillin Gd. tetracycline

ANSWER

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Topic 2: Antimicrobials $500 Answer

Which of the following antimicrobials has thebroadest spectrum of activity?

a. streptomycinb. isoniazidc. penicillin Gd. tetracycline

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Topic 3: Mode of Action $100 Question

Penicillin works by inhibiting ________ synthesis.

a. proteinb. cell wallc. plasma membraned. nucleic acid

ANSWER

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Topic 3: Mode of Action $100 Answer

Penicillin works by inhibiting ________ synthesis.

a. proteinb. cell wallc. plasma membraned. nucleic acid

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Topic 3: Mode of Action $200 Question

Eukaryotes have 80S ribosomes whereas prokaryotes have ________ ribosomes.

a. 90Sb. 80S c. 70S d. 60S

ANSWER

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Topic 3: Mode of Action $200 Answer

Eukaryotes have 80S ribosomes whereas prokaryotes have ________ ribosomes.

a. 90Sb. 80S c. 70S d. 60S

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Topic 3: Mode of Action $300 Question

The relationship between the antimetabolite sulfanilamide and para-aminobenzoic acid (PABA) is an example of

a. antagonism.b. competitive inhibition.c. synergism.d. bacteriostasis.

ANSWER

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Topic 3: Mode of Action $300 Answer

The relationship between the antimetabolite sulfanilamide and para-aminobenzoic acid (PABA) is an example of

a. antagonism.b. competitive inhibition.c. synergism.d. bacteriostasis.

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Topic 3: Mode of Action $400 Question

The mode of action of chloramphenicol is to

a. inhibit cell wall synthesis.b. inhibit nucleic acid synthesis.c. injure the plasma membrane.d. inhibit protein synthesis.

ANSWER

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Topic 3: Mode of Action $400 Answer

The mode of action of chloramphenicol is to

a. inhibit cell wall synthesis.b. inhibit nucleic acid synthesis.c. injure the plasma membrane.d. inhibit protein synthesis.

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Topic 3: Mode of Action $500 Question

The mode of action of antifungal drugs that target sterols is to

a. inhibit the synthesis of essential metabolites.b. injure the plasma membrane. c. inhibit nucleic acid synthesis.d. inhibit cell wall synthesis.

ANSWER

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Topic 3: Mode of Action $500 Answer

The mode of action of antifungal drugs that target sterols is to

a. inhibit the synthesis of essential metabolites.b. injure the plasma membrane. c. inhibit nucleic acid synthesis.d. inhibit cell wall synthesis.

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Topic 4: Resistance$100 Question

Bacteria that are resistant to large numbers ofantibiotics are popularly termed

a. superbugs. b. superinfections.c. MRSA.d. mutants.

ANSWER

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Topic 4: Resistance$100 Answer

Bacteria that are resistant to large numbers ofantibiotics are popularly termed

a. superbugs. b. superinfections.c. MRSA.d. mutants.

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Topic 4: Resistance$200 Question

If one measures a large zone of inhibition in adisk-diffusion test, one can assume that thebacteria are

a. sensitive to the antibiotic.b. resistant to the antibiotic.c. unaffected by the antibiotic.d. producing the antibiotic.

ANSWER

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Topic 4: Resistance$200 Answer

If one measures a large zone of inhibition in adisk-diffusion test, one can assume that thebacteria are

a. sensitive to the antibiotic.b. resistant to the antibiotic.c. unaffected by the antibiotic.d. producing the antibiotic.

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Topic 4: Resistance$300 Question

Which of the following is NOT a method ofantibiotic misuse?

a. prescribing antibiotics for the common coldb. finishing the full regimenc. using outdated antibioticsd. using antibiotics in animal feed

ANSWER

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Topic 4: Resistance$300 Answer

Which of the following is NOT a method ofantibiotic misuse?

a. prescribing antibiotics for the common coldb. finishing the full regimenc. using outdated antibioticsd. using antibiotics in animal feed

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Topic 4: Resistance$400 Question

What was the FIRST penicillinase-resistant drug to be developed?

a. vancomycinb. penicillin Gc. methicillin d. clavulanic acid

ANSWER

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Topic 4: Resistance$400 Answer

What was the FIRST penicillinase-resistant drug to be developed?

a. vancomycinb. penicillin Gc. methicillin d. clavulanic acid

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Topic 4: Resistance$500 Question

Gram-negative bacteria are relatively more resistant to antibiotics because

a. they are too small for the antibiotic to attack.b. they all have capsules that resist antibiotics.c. their cell wall restricts absorption of

molecules through porins.d. they secrete antibiotic-destroying compounds.

ANSWER

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Topic 4: Resistance$500 Answer

Gram-negative bacteria are relatively more resistant to antibiotics because

a. they are too small for the antibiotic to attack.b. they all have capsules that resist antibiotics.c. their cell wall restricts absorption of

molecules through porins.d. they secrete antibiotic-destroying compounds.

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Topic 5: Today and the Future $100 Question

Assessing the risks and benefits whenadministering drugs is termed

a. the therapeutic index.b. the assessment index.c. therapeutic management.d. assessment management.

ANSWER

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Topic 5: Today and the Future $100 Answer

Assessing the risks and benefits whenadministering drugs is termed

a. the therapeutic index.b. the assessment index.c. therapeutic management.d. assessment management.

BACK TO GAME

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Topic 5: Today and the Future $200 Question

Seventy percent of antibiotics produced in the United States are

a. used for treating disease.b. exported to other countries.c. used in animal feed to promote growth.d. available over the counter.

ANSWER

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© 2016 Pearson Education, Inc.

Topic 5: Today and the Future $200 Answer

Seventy percent of antibiotics produced in the United States are

a. used for treating disease.b. exported to other countries.c. used in animal feed to promote growth.d. available over the counter.

BACK TO GAME

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Topic 5: Today and the Future $300 Question

The chemotherapeutic effect of two drugs given simultaneously that is greater than the effect of either given alone is known as

a. symbiosis.b. commensalism.c. synergism. d. antagonism.

ANSWER

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Topic 5: Today and the Future $300 Answer

The chemotherapeutic effect of two drugs given simultaneously that is greater than the effect of either given alone is known as

a. symbiosis.b. commensalism.c. synergism. d. antagonism.

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Topic 5: Today and the Future $400 Question

Which of the following is NOT a way to prevent the development of resistance?

a. using broad-spectrum antibiotics when possible

b. always finishing the full regimen of antibioticsc. never using leftover antibiotics to treat new

illnessd. avoiding unnecessary prescriptions ANSWER

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Topic 5: Today and the Future $400 Answer

Which of the following is NOT a way to prevent the development of resistance?

a. using broad-spectrum antibiotics when possible

b. always finishing the full regimen of antibioticsc. never using leftover antibiotics to treat new

illnessd. avoiding unnecessary prescriptions

BACK TO GAME

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Topic 5: Today and the Future $500 Question

Magainins and squalamine are examples of what defense system produced by MOST forms of life?

a. complement systemb. antibodiesc. interferonsd. antimicrobial peptides

ANSWER

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Topic 5: Today and the Future $500 Answer

Magainins and squalamine are examples of what defense system produced by MOST forms of life?

a. complement systemb. antibodiesc. interferonsd. antimicrobial peptides

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FINAL ROUND Question

Russian scientists have experimented with what agents as a means of therapy for killing pathogenic bacteria?

a. helminthsb. bacteriophagesc. fungid. protozoa

ANSWER

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FINAL ROUND Answer

Russian scientists have experimented with what agents as a means of therapy for killing pathogenic bacteria?

a. helminthsb. bacteriophagesc. fungid. protozoa

BACK TO GAME