Degenerative Disorder

AN ABNORMAL NEURONAL BREAKDOWN

CHINUN B . [B . CH INUN@GMAIL .COM ]

Contents: 7 Neuronal Diseases

◉ Transmissible Spongiform Encephalopathies

◉ Parkinson's Disease ◉ Huntington’s Disease ◉ Alzheimer’s Disease ◉ Amyotrophic Lateral Scierosis ◉ Multiple Scierosis ◉ Korsakoff’s Syndrome

Evolving Concept ofDegeneration:

Not Aging and Normal Disorder Processes

▶ Lack of vital endurance ▶ Premature death

Pathology of Cell Death:

Necrosis an injured cell form which results in the premature death of cells in living tissue by autolysis.

It’s caused by external factors.

Apoptosis a process of programmed cell death

lead to characteristic cell changes and death.

Apoptosis and Degeneration:

Degeneration Disorders are more rapid neuronal loss, associated with deposition of

degenerative products

appear in cell molecular mechanism [normal] [apoptosis]

Degenerative Products: protein aggregation and inclusion body formation

[Characteristic Neurodegenerative Diseases involved Deposition of Abnormal Protein Aggregation]

Transmissible Spongiform Encephalopathies[ Pathology ]

Transmissible Spongiform Encephalopathies[ Incidence ]

Bovine Spongiform Encephalopathy (BSE) relates to TSE brain form1st Detection: 1980s in Great Britain

Transmissible Spongiform Encephalopathies[ The Origin and cause ]

Prion Protein

[ Pathology ]

Parkinson’sDisease

Parkinson’sDisease[ Incidence ]

[ The Origin and cause ]

Lewy Bodies & Misfolded Proteins Parkinson’sDisease

[ Symptoms]

Parkinson’sDisease

4[The Origin and cause ]

Huntington’s Disease

Huntington’s Disease[Pathology]

[ Symptoms]

Huntington’s Disease

Atrophy

Usually age 35 – 45 (+ or – 17 years)

Men and women equally

Younger people with Huntington's disease often have more severe case, and symptoms may progress more quickly

[The Origin and cause ]

Alzheimer’s Disease

[Pathology]

Alzheimer’s Disease

[ Symptoms]

Alzheimer’s Disease

[The Origin and cause ]

AmyotrophicLateralSclerosis

[Pathology]

AmyotrophicLateralSclerosis

[ Symptoms]

AmyotrophicLateralSclerosis

Medical Dilemma::

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