Disorders of thyroid gland

Dr. Sadaf Mumtaz1/03/11

Anti-thyroid drugs

Goiter

• Enlargement of thyroid gland

• Hypothyroidism– Primary failure of thyroid gland

T3 and T4, TSH Yes

– Secondary to hypothalamic or anterior pituitary failureT3 and T4,TRH & TSH No

– Lack of dietary iodineT3 & T4, TSH Yes

Hyperthyroidism

• Abnormal presence of long acting thyroid stimulators T3 & T4, TSH Yes

• Secondary to hypothalamic or anterior pituitary secretion T3 & T4, TRH & TSH Yes

• Hypersecreting thyroid tumor T3 & T4, TSH No

Exopthalmos

• Complex water retaining carbohydrates depoisted behind eyes

• Degenerative changes in extra-ocular muscles

Types of Hypothyroidism

• Endemic colloid goiter

• Idiopathic Non-toxic colloid goiter– Mild thyroiditis– Deficiency of enzymes

• Myxedema– Gel nature of excess fluid which is immobile– Edema is non-pitting

• Athersclerosis

Investigations

• Free thyroxine

• BMR

• TSH

• TSI

Cretinism• Congenital• Endemic

Thanks