Drug Delivery Systems

Mullner, M.; Schallon, A.; Walther, A.; Freitag,

R. Biomacromolecules, 2010, 11, 390-396.

Problem with cancer drugs

Most not water soluble

Toxic to healthy cells

Do not just target cancerous cells

Cause harmful side effects

New Design

Nanoparticle Template:

Use a micelle that makes drug water soluble

Micelle has hydrophilic outer layer and hydrophobic coreDrug is incorporated into hydrophobic coreNot harmful to body and allows careful delivery of medicine

http://www.uic.edu/classes/bios/bios100/f05pm/micelle.jpg

Bind a dye that can be used for imaging

Organic dye or quantum dot

Helps scientist track drug

Attach cancer targeting agent on outside of nanoparticle

Allows the drug to target specifically cancer cells

Almost no harm to healthy cells

Benefits

Longer circulation of drug

Targeting of cancerous cells = less harm to healthy cells

Target allows for more harm to cancerous cells

Cancer and chiropracticsJ Manipulative Physiol Ther 2001 (Jan);   24 (1):   52–57

A chiropractor can help provide noninvasive and non-pharmacologic options for decreasing pain and improving function.

Treatment may benefit those patients experiencing pain from the side effects of treatment or from the disease process itself

The chiropractor's treatment may include manipulation, soft tissue techniques, physiotherapeutic modalities, exercise, and ergonomic counseling.