Eye Tumor SPORE Update:Uniting to Advance Ocular Melanoma

Research

Robin Noe, MDEmory Eye Tumor SPORE Administrator

National Cancer Institute (NCI) Specialized Programs of Research

Excellence (SPORE)

Hans E. Grossniklaus, MD, MBA

Interim Vice Chair, Emory Eye Center

Professor of Ophthalmology and Pathology

Director, Section of Ocular Oncology and Pathology

Director, L.F. Montgomery Laboratory

Emory University School of Medicine

NIH

NCI

DCTD • TRP

Origins of SPORE

HHS

Translational Research“Translational” refers to the translation of basic scientific discoveries in a lab setting into practical ways to prevent,

diagnose, and treat human diseases.

Laboratory to Clinic

Clinic to Laboratory

Translational Research Program

Supports research in high incidence cancers as well as rare cancers

Institutional and other collaboration

Establishes organ-specific tumor specimen banks

Maintains 2 programs->develop new translational researchers

Invites advice of patient advocates who support translational research

Source Information: trp.cancer.gov

SPORESpecialized Programs of Research Excellence

Source information: trp.cancer.gov

Translational cancer research promoted by NCI via grant funding

A collaborative approach

Basic and Clinical Scientists work to discover new approaches to prevention, diagnosis, and treatment of human cancers

Methods developed for early cancer detection

SPORE Grant NIH P series grants

• Large multi-project efforts• Includes diverse array of research activities• P50 grant- Specialized Center Grant- funds

SPOREs

NIH R series grants• R01- Most frequently used grant program• P50 does not compete with R01• SPORE grant could be 4 individual R01 grants

Source Information: trp.cancer.gov

Source information: trp.cancer.gov

NIH Scoring

OVERALL IMPACT

The likelihood for a project to exert a sustained, powerful influence on research

field involved.

NIH Scoring:Evaluating Overall Impact

5 Individual Criterion Scored: Significance Investigator Innovation Approach Environment

Additional Criteria: Protection and inclusion of human subjects Vertebrate animal care and welfare Biohazards Scientific Collaborations

EMORY EYE TUMOR SPORE STRENGTHS

• Significance

• Innovation

• Investigators

• Environment

Conjunctival Malignant Melanoma has been added to the SPORE

Emory Eye Tumor SPORE

Principal Investigators:Hans E. Grossniklaus, MD

Erwin G. Van Meir, PhD

Hans E Grossniklaus, MD, MBAInterim Vice Chair Emory Eye CenterProfessor of Ophthalmology and PathologyDirector, L.F. Montgomery Pathology LaboratoryDirector, Section of Ocular Oncology and Pathology

Erwin Van Meir, PhDProfessor, Departments of Neurosurgery, Hematology and Medical OncologyDirector, Laboratory for Molecular Neuro-OncologyDirector, Emory Graduate Program in Cancer Biology

Emory Eye Tumor SPORE

Overall goal of our SPORE is to develop improved diagnostic techniques and therapies for

ocular tumors and their metastasis

Changed

ChangedP4 Teleimaging of

Ocular TumorsBB,CB

P3 Identify Markers for Development of RB DNA

Test

P4 Develop Innovative Molecular Tests for

Conjunctival Cancers

Score: OutstandingOverall Impact: High

Project 2:Early Detection and

Progression of Liver Metastatic Uveal Melanoma by

Precision MR Imaging

Jenny J. Yang, PhD (GSU)Pardeep Mittal, MD (Emory)

Hui Mao, PhD (Emory)

Score: Very GoodOverall Impact: Medium

Project 1:.

Entolimod for Treatment ofMetastatic Uveal Melanoma

Edmund Waller, MD, PhDDavid Lawson, MD

Andrei Gudkov, MD, PhD

Old Project 3 Score: Very GoodOverall Impact: Medium

New Project 3:Identification of Key Markers for the

Development of a DNA Test for Retinoblastoma

Hans E. Grossniklaus, MD Director J. William Harbour, MD Co-Director

J William Harbour, MDProfessor of OphthalmologyDirector, Ocular Oncology ServiceVice-Chair, Translational ResearchUniversity of Miami

Hans E Grossniklaus, MD, MBAInterim Vice Chair Emory Eye CenterProfessor of Ophthalmology and PathologyDirector, L.F. Montgomery Pathology LaboratoryDirector, Section of Ocular Oncology and PathologyEmory University School of Medicine

New Project 4:The Development of Innovative New ..

Molecular Tests for Conjunctival Squamous Cell Carcinoma (CSCC) and Conjunctival Malignant

Melanoma (CMM)

J. William Harbour, MD Director Carol L Karp, MD Co-Director

Old Project 4 Score: SatisfactoryOverall Impact: Medium

Anat Galor, MD, MSPH Co-Investigator

J William Harbour, MDProfessor of OphthalmologyDirector, Ocular Oncology ServiceVice-Chair, Translational ResearchUniversity of Miami

Carol L. Karp, MDProfessor of OphthalmologyRichard K. Forster Chair in OphthalmologyUniversity of Miami

Anat Galor, MD, MSPHAssociate Professor of Clinical OphthalmologyUniversity of Miami

Greater Outreach for Rare Eye Disease