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PowerPoint Presentation By Dr.P.L.John Israel
PowerPoint Presentation By Dr.P.L.John Israel
PowerPoint Presentation By Dr.P.L.John Israel
COMMON CAUSES
• Viral Rhinitis (Common Cold)• Sinusitis • Fevers• Hypertension• Refractive Error• Tension Headache• Hypoglycemia• Post ictal headache
PowerPoint Presentation By Dr.P.L.John Israel
SPECIFIC CAUSES
• Migraine Headache
• Cluster Headache
• Temporal Arteritis
• Post traumatic Headache
• Thunderclap Headache (Subarachnoid Haemorrhage)
PowerPoint Presentation By Dr.P.L.John Israel
Specific Causes Contd..
• Intracerebral Haemorrahage • Subdural Haematoma• Brain Abscess• Primary Brain Tumor• Metastatic Brain Tumor• Meningitis • Hydrocephalus• Glaucoma
PowerPoint Presentation By Dr.P.L.John Israel
BRAIN• Seat of intelligence• By itself is not sensitive to pain but the
adjacent structures protect the brain to make sure that the brain is safe.
• Headache is like an alerting signal• Face and scalp are richly supplied by pain
receptors than other parts of the body in order to protect the precious contents of the skull
• Also the nasal, oral passages , eye and ear all are delicate and highly sensitive structures which reside here and must be protected
PowerPoint Presentation By Dr.P.L.John Israel
CRANIAL STRUCTURES SENSITIVE TO PAIN
• The scalp• Scalp blood supply• Head and neck muscles• Great venous sinuses• Arteries of the meninges• Larger cerebral arteries • Pain –sensitive fibers of the fifth, ninth and tenth
cranial nerves• Parts of the dura mater at the base of the brain
PowerPoint Presentation By Dr.P.L.John Israel
• Migraine occurs commonly in – Females – 70% – Males – 30%
• Cluster Headache occurs almost entirely in men – 90%
• Tension Headache seen equally in both sexes
PowerPoint Presentation By Dr.P.L.John Israel
Location of Headache
• Hemicranial
• Bi-Temporal
• Occipital
• Frontal
• Peri-Orbital
• Vertex
PowerPoint Presentation By Dr.P.L.John Israel
Nature of Headache
• Constant
• Paroxysmal
• Lancinating
• Throbbing
PowerPoint Presentation By Dr.P.L.John Israel
PowerPoint Presentation By Dr.P.L.John Israel
MIGRAINE HEADACHE
• Familial Disorder characterised by periodic, Commonly unilateral , often pulsa tile headache.
• Age of onset– Begins in childhood , adolescents in early
adult life and diminishes in frequency and severity during advancing years. (Typically begins in teenage years and seldom begins after 40yeras of age)
PowerPoint Presentation By Dr.P.L.John Israel
TYPES
• Classic Migraine or Neurologic Migraine– Is characterised by aura
• Common Migraine– Migraine without aura
• Ratio – Classic Migraine : Common Migraine
1 : 5
PowerPoint Presentation By Dr.P.L.John Israel
CLASSIC MIGRAINE
• Prodrome :– Occurs hours to days before headache and consists
of change in mood, behavior, apetite and cognition.
• Aura :– Occurs within 1 hour of headache, and is most
commonly visual or sensory – Visual Aura
• Most Common• Consist of photopsias, bright flashing lights, scintillating
scotomas, field cuts and fortification spectra (zigzag lines / Teichopsia)
PowerPoint Presentation By Dr.P.L.John Israel
– Sensory Auras• Next most common feature • Characterized by numbness or paresthesiae in a limb
– Motor Weakness and aphasia are less common
• HEADACHE– Often unilateral (Hemicranial in 60% of ages) and
throbbing in nature– Follows aura with in 60minutes and lasts 4 – 72 hrs – Is associated with
• nausea,• vomiting • Photophobia (aversion to light)• Phonophobia (aversion to sound)
PowerPoint Presentation By Dr.P.L.John Israel
– Headache may be relieved after vomiting – Is aggravated by strain, routine physical
activity or rapid movement of the head– Some relief with pressure on temporal vessels– Strong Family History (80%)
• Migraine attacks come once or twice per month, or three tp four times per year
• There is a strong association with menstruation in females
PowerPoint Presentation By Dr.P.L.John Israel
• Common Migraine– Symptoms are similar to classic migraine but there
are no aura
• Precipitating factors– Foods rich in tyramine (Cheese, redwine)– Foods containing monosodium glutamine (Chinese
and Mexican foods)– Foods containing Nitrates (Cold cuts – bologna,
salami, smoked meats)– Pickled,fermented,marinated foods (pasta salads)– Alcoholic beverages (especially red wine)– Caffeinated beverages (soft drinks, tea and coffee)
PowerPoint Presentation By Dr.P.L.John Israel
ETIOPATHOGENESIS OF MIGRAINE
• VASCULAR THEORY– Vascular Theory of Migraine states that the
migraine aura is due to cerebral vaso constriction and that the migraine itself is caused by vasodilatation
– Cerebral blood flow is decreased during migraine with aura but there is no changes in blood flow during migraine without aura – Controversial
PowerPoint Presentation By Dr.P.L.John Israel
• ROLE OF SEROTONIN– 90% in GI Tract– 10% distributed in the brain and platelets– During Migraine attack, serotonin levels in the
blood may decrease where as urinary concentration may increase.
– This shift in serotonin level may trigger changes in blood vessels and blood flow and also alter pain perception in the brain.
PowerPoint Presentation By Dr.P.L.John Israel
• ROLE OF SEROTONIN– Serotonin may thus play a role in the cause of
migraine– Amtriptyline, nortryptyline & sumatriptan which
have an effect on serotonin metabolism are therefore useful in migraine headache.
PowerPoint Presentation By Dr.P.L.John Israel
• SUBSTANCE - P– The intra and extra cranial vessels are
innervated by small unmyelinated fibers derived from trigeminal nerve and subserve both pain and autonomic function.
– Activation of these fibers releases substance P and other peptides into the vessel valve.
– The peptides dilate the cerebral vessels and increase there permeability causing a throbbing headache.
PowerPoint Presentation By Dr.P.L.John Israel
Nitric Oxide
Nitric Oxide generated by endothelial cells has been
implicated as the cause of pain in migraine headache.
PowerPoint Presentation By Dr.P.L.John Israel
BASILAR MIGRAINE
• Basilar artery or vertebra basilar migraine – Less common form – Prominent brain symptoms – Seen usually in young women with a family history of
migraine– Have visual aura and may even develop temporary
cortical blindness– There may be associated vertigo, staggering, inco-
ordination of limbs, dysarthria and tingling both hands and feet and around the mouth
PowerPoint Presentation By Dr.P.L.John Israel
BASILAR MIGRAINE contd…..
– Exceptionally there can be period of coma or quadriplegia .
– The symptoms lost 10-30minutes followed by headache which may be occipital
– Some patients at the onset of headache may faint, or become confused or stuporous and this stage may persist for several hours or longer.
PowerPoint Presentation By Dr.P.L.John Israel
Ophthalmoplegic Migraine
• Characterised by recurrent unilateral headaches associated with weakness of extra ocular muscles
• Transient 3rd nerve palsy with ptosis with or without involvement of the pupil is the usual picture.
• 6th nerve is early effected common in children • Paresis may persist even after headache for
days to weeks.• Occasionally opthalmoparesis may remian
permanent.
PowerPoint Presentation By Dr.P.L.John Israel
Retinal Migraine or Ocular Migraine
• Characterised by retinal or optic nerve ischemia.• There may be retinal haemorrhages or
narrowing of retinal venules during and attack.• Mono ocular blindness, disc edema may occur
and vision recovers only partially after several months.
• The retinal or ciliary circulation may be involved.
PowerPoint Presentation By Dr.P.L.John Israel
Post Traumatic Migraine
• Occurs following trivial head injury there may be loss of sight, headache confusion for hours or days before recovering
• In others there may be hemiparesis or aphasia
PowerPoint Presentation By Dr.P.L.John Israel
Abdominal Migraine
• Seen in young children
• Instead of complaining of headache the child appears limp and pale and complains of abdominal pain.
• There may be vomiting and fever
• There may also be disturbances in mood along with abdominal pain.
PowerPoint Presentation By Dr.P.L.John Israel
Hemiplegic Migraine
• The infant, child or adult has episodes of hemiparesis that may outlast the headache.
• Has autosomal dominant trait with a family history (familial hemiplegic migraine).
PowerPoint Presentation By Dr.P.L.John Israel
Complicated Migraine Or
Migranous Infarction• Here the temporary nerologic symptom of
migraine headache may remain permanent • Ex : A Homonymous visual field defect • Platelet aggregation, edema of the arterial wall
increased coagulability of blood, intense prolonged spasm of vessels have all been implicated in the pathogenesis of arterial occlusion and strokes that complicate migraine
PowerPoint Presentation By Dr.P.L.John Israel
• In children with mitochondrial disease (MELAS- Mitochondrial Myopathy- Encephalopathy Lactic Acidosis and Stroke like Episodes)
• And in adults with rare vasculopathy
(CADASIL – Cerebral Autosomal Dominant Arteriopathy
with Subcortical Infarcts and Leuko Encephalopathy), Migraine is prominent feature
PowerPoint Presentation By Dr.P.L.John Israel
STATUS MIGRAINOSUS
• Continuous migraine with unilateral throbbing and disabling headache.
• May follow head injury or viral headache.
PowerPoint Presentation By Dr.P.L.John Israel
Premenstrual / Menstrual Migraine
• Is thought to be due to withdrawal of estrogens.
• Migraine attacks tend to cease during pregnancy in 75-80% of patients
• Oral contraceptive pills or associated with increased frequency and severity of migraine and may be even be associated with permanent neurologic deficit.
PowerPoint Presentation By Dr.P.L.John Israel
FOOTBALLERS MIGRAINE
• Sudden jarring of the head may precipitate the migraine attack in susceptible footballers
PowerPoint Presentation By Dr.P.L.John Israel
TREATMENT OF MIGRAINE
•Treatment of Acute Attack (Primary treatment)
•Prophylactic treatment
PowerPoint Presentation By Dr.P.L.John Israel
Treatment of Acute attack(Primary Treatment)
• Mild attack of migraine– Acetaminophen– NSAIDS
• Severe attack– Ergot alkaloids:
• Ergotamine /Dihydroergotamine (DHE)• Best given at the on set of attack
– Is an α adrenergic agonist with a strong serotonin receptor affinity and has a vasoconstrictor action.
PowerPoint Presentation By Dr.P.L.John Israel
– Available as oral, sublingual, injectable and inhalation forms
• 1 – 2mg every half an hour (Dose ) Sublingual or to be swallowed
• Maximum dose (8mg)
– A Single dose of promethazine (Phenergan) 50mg or Metaclopramide (Reglan) 20mg given along with ergotamine relaxes the patient and allays nausea and vomiting.
– Caffeine 100mg is thought on slim evidence to potentiate the effects of ergot and other medications for migraine
– Reduces headache in 70-75% of patients.
PowerPoint Presentation By Dr.P.L.John Israel
5HT Receptor Agonists
• Sumatriptan – Is effective at stopping acute attack of migraine
headache– Can be given subcutaneously 6mg– As intranasal spray 20mg– Or orally 50-100mg– Provide relieve in 70% patients.
• Side Effects– Chest tightness & flushing – Should not be used concomitantly with
ergotamines or inpatients with heart disease
PowerPoint Presentation By Dr.P.L.John Israel
Other 5HT Receptor Agonists
• Zolmitriptan 2.5 to 5mg
• Rizatriptan 10mg– Doses can be repeated if needed in 2hrs
PowerPoint Presentation By Dr.P.L.John Israel
MIDRIN
• Is a combination medication that consists of dichloralphenazone (a muscle relaxant), isometheptene (a vasospasm agent) and acetaminophen.
• May be used as abortive therapy (2tabs with onset of headache) and one tab every hour after that, up to 5 tabs total.
• As prophylaxis ( 1tab 2-3times per day)
PowerPoint Presentation By Dr.P.L.John Israel
Prophylactic Treatment
• When headache occur at frequency of 2-3 per month the following drugs have been effective of prophylactic agents– Beta –Blockers
• Inderal – 20mg TID can increase up to 240mg /day• Atenolol – 40 to 160mg/day • Timolol - 20 to 40 mg /day• Metoprolol – 100 to 200 mg /day
PowerPoint Presentation By Dr.P.L.John Israel
• Sodium valproate - 500mg/day (upto 1000mg /day)
• Calcium channel blockers– Verapamil - 180 to 240mg /day– Nifedepine - 30 mg /day
• Tricyclic Antidepressants (Amitriptyline,Imipramine) – Amitriptyline – 25mg HS – OD increase upto
200mg/day (increase 25mg /week)– Side effects
• Dry mouth• Constipation• Urinary hesitancy• Sedation• Weight gain,
PowerPoint Presentation By Dr.P.L.John Israel
• Methysergide– Serotonin agonist , vasoconstrictor. Highly effective
for primary treatment but has side effects on prolonged use (Retroperitoneal fibrosis, Pulmonary fibrosis)
– Dose : 2 to 6 mg/day
• Other Drugs– Clonidine – 0.5mg TID/day– Cyproheptadine – 4 to 16mg /day– Flunarazine – 5 to 10mg/day– Indomethacin – 150 to 200mg /day
PowerPoint Presentation By Dr.P.L.John Israel
CLUSTER HEADACHE
• Also known has – Paroxysmal nocturnal cephalalgia– Migrainous neuralgia– Histamine cephalalgia – Red Migraine– Erythromelalgia of the Head
PowerPoint Presentation By Dr.P.L.John Israel
CLUSTER HEADACHE
• So called because these headaches occur during a short time span.
• The cluster then recurs periodically.• A typical cluster of headaches may last 4-8weeks with 1-
2 headaches/day during the cluster.• Patient may be free 6months to 1year before another
cluster of headache occurs.• They may be distinctly seasonal.• Young adult Men (20-50 yrs age) are more affected then
women • Male to Female ratio 5:1
PowerPoint Presentation By Dr.P.L.John Israel
SYMPTOMS
• Abrupt onset of headache originating in the eye and spreading over the temporal area.
• Pain extremely severe and last 20-60minutes
• The headache associated with – Nasal stuffiness – Rhinorrhoea– Redness of the Eye– Flush and edema of the cheek
PowerPoint Presentation By Dr.P.L.John Israel
SYMPTOMS
– There may also be partial Horner’s Syndrome with ptosis and miosis on the side of The Head pain. These autonomic phenomena are similar to those elicited by local action of histamine and was therefore previously called Horton’s Histamine Headaches
– These headaches are usually nocturnal, between 1-2hrs after the onset of sleep are several times during the night and day not associated with aura or vomiting. The headache recurs with remarkable regularity each day for periods that last over 6-12weeks
PowerPoint Presentation By Dr.P.L.John Israel
CAUSE AND MECHANISM OF CLUSTER HEADACHE
• Not clear
• Probably due to paroxysmal parasympathetic discharge mediated through the greater superficial petrosal nerve and sphenopalatine ganglion
PowerPoint Presentation By Dr.P.L.John Israel
CLUSTER MIGRAINE
• These persons have characteristics of both migraine headache as well as cluster headache
PowerPoint Presentation By Dr.P.L.John Israel
TREATMENT
• Ergotamine 2mg at bedtime• Inhalation of 100% oxygen for 10 – 15min at
onset of the headache• Intranasal lidocaine or sumatriptan• Methysergide 2-8 mg/day• Prednisolone - 75mg / day for 3days and then
taper the dose• Verapamil – upto 480mg /day • Lithium – 600 to 900mg/day (blood level of
lithium must be between 0.7 to 1.2 meq/Lt)• Indomethacin – 75 to 200mg /day
PowerPoint Presentation By Dr.P.L.John Israel
PowerPoint Lecture Presented by Dr.P.L.John Israel
Prof & HOD , Department of Internal Medicine