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by:- Shagufta by:- Shagufta

Multi enzyme complex

Uploaded By: Abdul Qahar Buneri(The Great)

AWKUM (Buner Campus)

1.Acyl transfer step1.Acyl transfer step

• O • HS-CYS• CH3-C-S-COA + ACP

HS-PN

ACETYL

TRANSFERASE COA-SH

O

CH3-C-S—CYS

ACP

HS-PN

2.MALONYL TRANSFER STEP2.MALONYL TRANSFER STEP

O

CH3 — C — S— CYS

ACP

HS — PN

+

COO —CH2 —C —S —COA

ACP MALOYNYL SH-COA

TRANSFERASE

O

CH3-C-S-CYS

ACP

O

COO-CH2-C-S-PN

3.Condensation Step3.Condensation Step

O

CH3-C-S-CYS

O ACP

COO-CH2-C-S-Pn

keto acyl H+

transferase

CO2

HS-CYS

O O ACP

CH3-C-CH2-C-S-Pn

4.Keto reducton step4.Keto reducton step

HS-CYS

O O ACP

CH3-C-CH2-C-S-Pn

NADH+H+

keto acyl Acp

reductase NADP+

HS-CYS

OH O ACP

CH3-C-CH2-C-S-Pn

H

5.Condensation step5.Condensation step

HS-CYS

OH O ACP

CH3-C-CH2-C-S-Pn

Hydroxacyl H2O

Acp reductase

HS-CYS

O ACP

CH3-CH=CH-C-S-Pn

6.Saturation6.Saturation

HS-CYS

O ACP

CH3-CH=CH-C-S-Pn

enoyl Acp NADPH+H+

reductase

NADP+

HS-CYS

O ACP

CH3-CH2-C-S-Pn

7.The Transfer Step7.The Transfer Step

HS-CYS

O ACP

CH3-CH2-C-S-Pn

Non Enzymatic

step

O

CH3-CH2-C-S-CYS

ACP

HS-Pn

8.Clevage8.Clevage

CH3-CH2-C-S-CYS

ACP

O

HS-Pn

Hydrolytic H2O

Enzyme

HS-CYS HS-CYS

ACP + ACP

HS-Pn O

C-S-Pn

CH3