NANO BASED POLYMERS AND

APPLICATIONS

(DRUG DELIVERY)

Presented By:

Mr. Anil Kumar

M.Phil./ Ph.D. Nano-science (2012-13)

Centre for Nano-science

Central University of Gujarat

NANO POLYMERS FORMATION

Bulk Material

Macro Micro Nano

MoleculesMonomers

units

Å

Nano

Polymers

Small Bulk Material

or Micro Polymers

Å

Bottom Up Approaches Top Down Approaches Nano

Lysis of Bulky Materials:- Synthesis of

Materials (Nano

Composites):-1. Chemolysis. (Use organic

solvents )

2. Thermolysis. (ΔG = ΔH –

TΔS)

3. Radiation. (Break chemical

bonds, phenolic ,

polystyrene)

4. Diffusion. (stirrer with high

speed)

5. Enzymolysis. (cellulase,

pectinase, ribulase..etc.)

6. Biodegradation. (bacteria,

fungi, algae ..etc.)

1. Self Assembling. (Inter or

Intra Molecular

Interaction)

2. Crystallization. ( Solid

and Liquid )

3. Precipitation. ( Liquid and

Liquid recovery of salt

and metals)

4. Sol-Gel. (NM + Organic

Solvent + Gel)

5. Molecular

Interaction.(Ionic

Interaction)

6. Biosynthesis. (Recovery

Na

no

po

lym

ers

Techniques Applied formation To

Nano Polymers

Model of Surface-to-volume

Comparisons…

Neglecting spaces between the smaller boxes, thevolumes of the box on the left and the boxes on the rightare the same but the surface area of the smaller boxesadded together is much greater than the single box.

Single Box Ratio

6 m2

1 m3 = 6 m2/m3

Smaller Boxes Ratio

12 m2

1 m3 = 12 m2/m3

PROPERTIES

Structural :- Platelets, Fibers, Spheroids, Linear, Branch, Network..etc.

Physical & Chemical:- Like as Stiffness, Strength, Stability, etc. (2D,3D).

Typical Structures are:

• Linear (end-to-end, flexible) .

• Branched(one end free, other attached to stalk polymer).

• Network (similar to highly cross-linked structures,termosetting polymers).

Polymer has a Multidisciplinary

Field of Science & Technology

Nano Based Polymers Types

Chemical Synthetics

- Polyglycolic acid (PGA)

- Polylactic acid (PLA)

- PGA-PLA

- Polydioxanone (PDO)

- Polycaprolactone

- PGA-polycaprolactone

- PLA-polycaprolactone

- Polydioxanone-polycaprolactone

Natural

- Elastin

- Gelatin collagen

- Fibrillar collagen

- Collagen blends

- Fibrinogen

- Heamoglobine

NANO BASED SOME POLYMERS AND APPLICATIONBroad Fields Nano Size Polymers Applications

Chemicals PVC. (Poly vinyl chloride) Raincoats, shower curtains, water pipes

PMMA. (Poly methyl

methacrylate)

Plastic base glasses

PE. (Polyethylene) Grocery bags, shampoo, bottles, children’s toys,

bulletproof vests

PS. (Polystyrene) Comb, TVs body,. radio knobs. drinking cups foamy

PP. (Polypropene) packaging, textiles (e.g. ropes, thermal underwear,

carpets), stationery, plastic parts laboratory,

equipment, loudspeakers,

PPS. (Poly phenylene

sulfide)

Resist chemical and thermal attacks

ABS. (Poly acrylonitrile

butadiene styrene)

Very strong and lightweight polymer. It is strong

enough to be used to make automobile body parts

PNBR. (Polymer Nitrile

Buna-N rubber)

Cleaning of lab equipment, sophisticated,

instruments and examination gloves.

Biological Immunogenic Immunoglobulin (IgA, IgD, IgE, IgG, IgM)

Antigenic Epitope, Motifs, TCR (CD4,CD8), MHC

Lipids Emulsions Mixture (HC+H2O)

Liposomes Micelle, Amphipathic

Metals Nanoshell Cover (Sphere) of NP

Nanocomposites NP + Polymer

Fibers Nanosphere Careers Nanoparticles(amino, carboxyl, surfaces)

Nanocapsule Fiber Coat (Medicine coat, cover)

Outline Process of Nano-Vector

Nano polymer mostly can be very effective to be Designing a

Drug as name “NANO VECTOR” by using of Nano Polymers and

Nano Materials in size nano range and also Applied for induced

tumor cells available in Critical Organs of Body such as

Brain, Lung, Heart...etc. These vector designed a typical

types, who are search to target site, that target site a specific

receptor Presented in outer cell membrane of the tumor cell

receptor made be become Biomolecules it bind by various ways

and released to NP into tumor cells. Where It are do The tumor

Cells Remove or Destroyed as may be possible without surgery

Because Some Tumor Cell have arises to another Tumor Cell by

Cell Cycling, here break Cell Cycling by This Nano Vector will as

a processing inhabit of protein synthesis of tumor cell.

DNA Strand in nm

Nano-Vector

DNA Strand

Nano-Vector

Nanoparticle

(Drugs)

DNA Strand

Nano-Vector

Nanoparticle

(Drugs)

Covering of NP by DNA Polymer

DNA Strand

Nano-Vector

Covering of NP by DNA Polymer

Covered of NP by DNA Polymer

Nanoparticle

(Drugs)

DNA Strand

NP

vector with

Drugs

vector with

Drug

Moieties Target

(Receptors)

Nanovector

with Durg

Moieties Target

(Receptors)

vector with

Durg

Moieties Target

(Receptors)

vector with

Durg

Moieties Target

(Receptors)

Nano vector with various

moiety receptors

Assembled Nano Vector (Drug)

Thank You

for a kind Attention