Kuby IMMUNOLOGYSixth Edition

Chapter 1

Overview of the Immune System

Copyright © 2007 by W. H. Freeman and Company

Kindt • Goldsby • Osborne

Metchinikoff,

Phagocytosis, macrophages surrounding a foreign particel

1990,Ehrlich

Side chain theory

Cells in blood expressed

a variety receptor

Like key and lock

1950, Clonal selection

Rota virus, 1million death/yr

Pseudomonas ingested by macrophage

Candida albicans

Larva of Filaria attacked by macropahges,

120 million infection

Tyrosine

Serine

Threonine

105 MBA per cell

Secreted Ab

EM of APC (right) associating with T lym

CTLs (cytotoxic T lymphocytes)

Lag phase 5-7d

B cell, Th, Plasma cellLag phase 1-2d

Memory B cells

100-1000 folds

Allergic reaction to a bee stingImmune Dysfunction:

Allergies and asthma—anaphylaxis (anaphlactic reaction),

dog against toxin from jellyfish, physalia. IgE and Mast cells

Graft rejection and graft vs host disease, bone marrow transplantation, antigraft drug,

1930,Landsteiner ABO grouping, 1980 Thomas and Murry, MHC

Autoimmune disease—multiple sclerosis, Crohn’s disease, Rheumatic,

Immunodeficiency, IgA lacking, SCID (T, B cells ), AIDS

Asthma

Food allergy

Tree nut, peanuts

3 million American

Ban peanuts from school and airplane

Epinephrine injection or suction