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2
CHRISTOPHE SCHILLING, Ph.D.
TAGLIO DI PO, ROVIGO, ITALY
SEPTEMBER 30TH, 2016
THE VALUE OF A STRATEGIC PARTNERSHIP TO BUILD TECHNOLOGICAL
LEADERSHIP
4 Strategic Partnership for the Bioeconomy…starting with BDO Collaboration grounded in shared principles that drive successful commercialization of high impact technologies
pioneering innovation mindset
belief in the power of biotechnology
passion for sustainable development
Genomatica Innovation Center San Diego, California
About Genomatica
• Bioengineering Technologies for the chemical industry • Privately-held, founded in 2000 • San Diego, California a US biotechnology hub • ~ 80 employees • > 50% advanced technical/business degrees
6 Bioengineering innovations disrupting traditional value chains Complete platform to “industrialize” biotechnology; combining synthetic biology and bioprocess engineering
7 Driving Technologies from Concept to Commercial Realization
Core competencies across computation, experimentation, and bioprocessing, all tightly integrated
optimizing cell factories
integrating process design & engineering
engineering enzyme components
high fidelity scaling to commercial
Enabling Science& Discoveries
CommercialRealization
in silico design &prototyping pathways
guiding with techno-economics
Innovation Engine systems bioengineering
optimalpathway
bank
Lab Pilot Demo Commercial
$/ton
Scalable Engineering
Idea Conception & Modeling Analysis
8 Global Symbol for the Bioeconomy Novamont’s Mater-Biotech BDO Plant harnesses the power of biotechnology with the Genomatica GENO BDO Process
9 Ideation and design of the optimal BDO Organism - 2007 Metabolic Engineering designs for the first organism to produce 1,4-Butanediol from sugars
Carbohydrates
1,4-Butanediol
O
HO OHOH
OHHO
six-carbon sugars (ex. dextrose)
five-carbon sugars (e.x. xylose)
disaccharides (ex. sucrose)
10 The First BDO Producting Organisms - 2008 Genetically engineering E. Coli bacteria converting sugar into 1,4-butanediol
11
O
HO
OH
OH
OH
OPO3
O
OH
OH
HO
HO
OPO3
“Single Step Biocatalyst” converting Sugar into Butanediol Sequence of biochemical reactions convert sugar into BDO inside the organism
O
HO
OH
OH
OH
HO
O
OPO3
OH
HO
HO
OPO3
OH
O
OPO3
O
OH
OPO3
OPO3
OH
OPO3
O
OPO3
OH
OPO3
O
OH
OH
OPO3
O
OH
OH
OPO3
O
OH
OPO3
OH
O
OH
OPO3
OH
O
OH
OPO3
O
OH
OPO3
O
Dextrose Sugar 1,4-Butanediol
12 Purified 1,4-Butanediol - 2009 Designed and tested full process to produce on-spec BDO from sugars
13 Scaling-up the GENO BDO Process – 2010 to 2013 Move from Lab-Scale to Commercial-Scale validation with partners facilities and cooperation
3,000 Liter piloting
2010
Integrated Demonstration Plant
2011
Shipping Tons of Product
2012
Commercial Scale Campaigns
2013
14 The Journey toward the Mater-Biotech BDO Plant Setting new standards, 5 years concept to commercial scale, and now the world’s first dedicated bio-BDO plant
Mater-Biotech BDO Plant
family of biodegradable & compostable bioplastics
• enabling strategic partnership
• world’s 1st bio-based plant for a major intermediate chemical
• differentiated BDO applications
3,000L
13,000L
2013…Commercial scale
2012 campaignsShipping tons
2011Integrated demo plant
2010Piloting
2009Purified BDO
2008BDO producing organisms
GENO BDOTM Process Technology
15 Potential to serve existing BDO market applications $4B global market producing 2 Million tons – exact same chemical made a better way
1,4-Butanediol(BDO)
THFTetrahydrofuran
PBTPolybutylene Terephthalate
Spandex / Elastane
Polyurethane
Polyester
GBLGamma-Butyrolactone
Direct useDerivativesDownstream
Exact same chemical …now made a better way
16 Driving a Broader Transformation toward Green Chemicals Technologies targeting Large Existing Markets in Basic, Intermediate, and Specialty Chemicals
Applications for Renewables packaging apparel automotive carpeting cosmetics personal care nutraceuticals
Volume
$/ton
* Not to scale
Pharma, FlavorFragrance
Intermediate Chemicals ~30 products Ave. $9Bn each
Butadiene$20Bn+
BDO $4Bn
CPL$10Bn
ADA$6Bn
HMD$3Bn
Basic Chemicals 7 products Ave. $37Bn each
Specialty Chemicals 100’s of products $100M-1Bn each
$1-2Tn Core of the Chemical Industry
Genomatica Process Technologies
17 Accelerating the Pace of Bioprocess Technology Development New Strategic Alliance between Genomatica and Ginkgo Bioworks, a leader in organism engineering
• New alliance announced September 29 between technology leaders with highly complementary platforms
• Brings more capabilities to rapidly engineer organisms leveraging automation and ‘semi-conductor like’ foundries
• Advances in biotechnology continue to reduce the cost of R&D, and accelerate the potential for new technologies
18 Bright Future for the Bioeconomy Combined Team of Talented Passionate People have made this Achievement Possible
Team Novamont – leadership, vision, courage, drive, and determination
Investors – financiers supporting Novamont, Genomatica, and the Mater-Biotech project
National & Regional Support – openness to local revitalization and a bioeconomy vision
Mater-Biotech Team – dedication in construction, commissioning, start-up, and operations
On behalf of everyone at Genomatica we wish to acknowledge and provide our deepest thanks to:
19
CHRISTOPHE SCHILLING, Ph.D.
TAGLIO DI PO, ROVIGO, ITALY
SEPTEMBER 30TH, 2016
THE VALUE OF A STRATEGIC PARTNERSHIP TO BUILD TECHNOLOGICAL
LEADERSHIP