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JACC. September 23, 2014. Accepted Manuscript DR. JUAN CARLOS BECERRA MARTÍNEZ Fellow en Cardiología Intervencionista, UMAE HE CMNO ACC Fellow in-Training Miembro ESC, EAPCI, SCAI, SOLACI, SOCIME, CCJ 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

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2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

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Page 1: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

JACC. September 23, 2014. Accepted Manuscript

DR. JUAN CARLOS BECERRA MARTÍNEZ

Fellow en Cardiología Intervencionista, UMAE HE CMNO

ACC Fellow in-Training

Miembro ESC, EAPCI, SCAI, SOLACI, SOCIME, CCJ

2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Page 2: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

JACC. September 23, 2014. Accepted Manuscript

Page 3: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Pathophysiology

JACC. September 23, 2014. Accepted Manuscript

Page 4: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Presentation

JACC. September 23, 2014. Accepted Manuscript

Page 5: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

TIMI Risk Score

JACC. September 23, 2014. Accepted Manuscript

Page 6: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

GRACE Risk Model

JACC. September 23, 2014. Accepted Manuscript

Page 7: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Early Risk Stratification

JACC. September 23, 2014. Accepted Manuscript

Page 8: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Cardiac Biomarkers

JACC. September 23, 2014. Accepted Manuscript

Page 9: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Medical Management

JACC. September 23, 2014. Accepted Manuscript

Page 10: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Medical Management

JACC. September 23, 2014. Accepted Manuscript

Page 11: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Medical Management

JACC. September 23, 2014. Accepted Manuscript

Page 12: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Medical Management

JACC. September 23, 2014. Accepted Manuscript

Page 13: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Aspirin

JACC. September 23, 2014. Accepted Manuscript

Page 14: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

P2Y12 Inhibitors

JACC. September 23, 2014. Accepted Manuscript

Page 15: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

GP IIb/IIIa inhibitors

JACC. September 23, 2014. Accepted Manuscript

Abciximab: better downstream

Page 16: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Parenteral anticoagulant

JACC. September 23, 2014. Accepted Manuscript

Page 17: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

JACC. September 23, 2014. Accepted Manuscript

Page 18: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

JACC. September 23, 2014. Accepted Manuscript

Page 19: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Strategies

JACC. September 23, 2014. Accepted Manuscript

Page 20: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Non-anginal pain management

JACC. September 23, 2014. Accepted Manuscript

Page 21: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Special patient groups

JACC. September 23, 2014. Accepted Manuscript

Page 22: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Special patient groups

JACC. September 23, 2014. Accepted Manuscript

Page 23: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Special patient groups

JACC. September 23, 2014. Accepted Manuscript

Page 24: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Special patient groups

JACC. September 23, 2014. Accepted Manuscript

Page 25: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Special patient groups

JACC. September 23, 2014. Accepted Manuscript

Page 26: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Special patient groups

JACC. September 23, 2014. Accepted Manuscript

Page 27: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Puntos a discutir…1.- Ya no usar CKMB ni mioglobina en el abordaje diagnóstico

2.- BNP es útil en estratificación

3.- Mejor ticagrelor/prasugrel que clopidogrel

4.- Prasugrel solo si se colocan stents

5.- Mejor eptifibatide/tirofibán que abciximab para terapia “upstream”

6.- Bivalirudina solo en estrategia invasiva

7.- Pacientes con fondoparinux: hacer switch a otro anticoagulante en caso de cateterismo

8.- La estrategia “conservadora inicial” ahora se llama “guiada por isquemia”

Page 28: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Puntos a discutir…9.- Cuatro estrategias de tratamiento:

- Guiada por isquemia (antes conservadora)

- Invasiva Inmediata (2 hrs)

- Invasiva temprana (24 hrs)

- Invasiva tardía (25-72 hrs)

10.- Se añade la pirámide invertida de analgésicos

11.- B-bloqueadores pueden desencadenar espasmo coronario en pacientes con uso reciente de cocaína / metaanfetaminas

12.- Nuevas recomendaciones sobre Takotsubo

Page 29: 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes

Gracias!