Bio-Strike

Rüdiger Trojok ITAS, University Kalrsruhe

Technikfolgenabschätzungsbüro beim Bundestag

Opentechsummit, Berlin 14.05.2015

Souce: center for disease control

Tragedy of the Commons:Antibiotics crisis

overuse of antibiotics

spread of antibiotics in environment

development of resistant bacteria

by mutation

Antibiotic crisis

overuse of antibiotics

spread of antibiotics in environment

development of resistant bacteria

by mutation

spread of resistance genes by Horizontal Gene Transfer

resistance genes render antibiotics useless

Antibiotic crisis

Antibiotics CrisisMarket failure1990– 18 companies, – 10 new antibiotics

2011 – 4 companies, – 2 new antibiotics

Antibiotics CrisisD

rug

/ Bi

llion

US

Dol

lar

Solutions

• Reduce antibiotic consumption– Regulation– Management– Education

• Research new antibiotics• Find entirely new cures…

Citizen Science Initiative Biostrike !

Scenario I

Decentralized RESEARCH Centralized

Biostrike

9http://synthesis.cc/

Bio-Language AGTC

Scenario I

Scenario II

Decentralized RESEARCH Centralized

Biostrike

12Prof. Blaney, Broad Institute http://www.youtube.com/watch?v=66Oc8fLKXlE

Moore‘s law for Biolabs

Digital biology

Nanopore Sequencing

MicrofluidicsSynthesisAnalog Biology

Digital Biology

AGTC

Phage Therapy

• Well known since 100 years• Programmable• Highly specific• Safe

Wetware

Software

Hardware 0

Bio-Commons License

Biostrike

Citizens / NGOs / Academics

§§

Personalized Phages

Ampicillin(blocks D-Alanin-Transpeptidase )

BakteriaWith cell wall (grampositiv)

PlasmidWith AmpicillinResistannce gene

beta-lactamase(destorys Ampicillin)

Ampicillin Resistenz