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The Blue Brain Project

“Imagination is more important than knowledge”, Einstein

Brain Mind Institute

and the Emergence of Perceptions

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Emergence of Man

The Elementary Modules of the Neocortex





Neocortical Columns are made according to a Stereotypical Recipe of Neurons and Connections

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Reverse Engineering the Neocortical ColumnMulti-neuron Patch-Clamp Recording





Markram & Sakmann, J.Physiol, 1994Markram, Lubke, Frotcher, Sakmann, Science, 1997Markram, Lubke, Frotscher, Roth, & Sakmann, 1997

Multineuron Patch-Clamp



Butterflies of the Cerebral Cortex

Yun Wang

Morphological Classes of Neocortical Neurons

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Repairing & Cloning 3D Neuron Morphology Models

Electrical Behavior of Neurons

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100mV Voltage Spikes = Action Potentials

I

V

threshold

Diversity of Electrical Behaviors of Neocortical Neurons

Soma Targeting INTS LBC_bADLBC_bISLBC_bNALBC_cADLBC_cFSLBC_cSTLBC_c NALBC_dFSLBC_dSTNBC_bNANBC_cAD

NBC-bADNBC_cFSNBC_c NANBC_dFSNBC_dST

NBC-cSTNBC-dADNBC-bSTSBC_bNASBC_cADSBC_cFSSBC_c NASBC_dFS

Axon Targeting INTS ChC_cADChC_cFS

ChC-dNAExcitatory Neurons SSC_cAD

SSC_cST

L2PC-cADL3PC-cADL4PC-cADL4SP-cADl4SS-cADL5CSPC-cADL5CHPC-cADL6CTPC-cADL6CCPC-cADL6CSPC-cAD

Bipolar

Bitufted

Multiple Electrical Types in Each Morphological Class

me-TypeTuft targeting INTS HC-cFS

HC-cADCRC-cADCRC-cFSMC_bADMC_bNAMC_cADMC_cFSMC_c NAMC_dFS

MC-bSTNGC-dFSNGC-dAL

Dendritic Targeting INTS NGC-dNABP_bISBP_bNABP_cADBP_cISBP_c NABTC_bADBTC_bISBTC_bNABTC_cADBTC_cFSBTC_c NADBC_bADDBC_bISDBC_bNADBC_c ADDBC_cISDBC_c NA

Health & Medicine

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