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J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Generation and In Situ Modification of Customized IOLs
J. F. Bille , R. Sahler , R. Aguilera , S. Zhou, D. J. Schanzlin 1) University of Heidelberg, Germany, 2) Aaren Scientific Inc, USA, 3) Shiley Eye Center, UCSD, USA,
1, 4 1, 2 2 3 2
Prof. Dr. J. F. Bille
• Aaren Scientific - C, P
• Heidelberg Engineering – C, P
Ruth Sahler
• Aaren Scientific - E
Rick Aguilera
• Aaren Scientific - E, O
Stephen Zhou
• Aaren Scientific - E
Prof. Dr. D. J. Schanzlin
• Aaren Scientific - C
Financial Disclosure
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Content
• Motivation • Refractive Index Shaping (RIS) • The Instrument • Phase Wrapping Algorithm • Aspheric / Toric IOLs
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Motivation
Reference: Market Scope Report 2010
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Concept
After:
Before:
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Refractive Index Shaping (RIS)
Free Electrons (Lucky) are created Electrons can absorb photons
Bond re-structuring Avalanche Effect creating a plasma
Molecules
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
RIS Key Points
• Refrac've index (RI) of the shaped lens is higher than the refrac've index of the surrounding IOL material
• The geometry of the 'lens' is determined by the pa@ern of laser beams hiAng the targets
• The diopter change is due to the refrac've index change and the curvature of the three dimensional shaped 'lens' object
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
2 Photon Microscope with 500mW Laser
500mW Laser
AOM
(Acousto Optic Modulator)
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
RIS Max and Min Speed
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Max RIS Speed
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Refractive Index Change
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Phase Wrapping Theory I
• The RIS area is limited to ~200um
• A traditional convex lens would therefore be limited to that height
• The power for a 6mm lens with a height of 200um would be 0.44dpt (Δn = 0.01)
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Phase Wrapping Theory II
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Toric IOL
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Aspheric IOLS
Peripheral Ray
Spheric Lens
Aspheric Lens
J.F. Bille, R. Sahler, R. Aguilera, S. Zhou, D.J. Schanzlin -‐ 03/ 28/11
Summary
• A novel method for generation and in situ modification of customized IOLs has been developed.
• Refractive Index Shaping (RIS) can be used to adjust the power of an IOL in situ by focused infrared femtosecond laser pulses.
• RIS was successfully performed on Aaren‘s hydrophobic acrylic IOLs and modified formulations with enhanced UV absorber.
• Employing phase wrapping techniques, several diopters of refractive change can be accomplished in a thin layer of approximately 50µm thickness.
• Using an acousto-optic modulator (AOM) a total processing time of approximately 20 seconds can be achieved.