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RECENT ADVANCES IN MANAGEMENT OF PARKINSON'S DISEASE

MISS.SULTANA SHAIKH (M.PHARM STUDENT) ORIENTAL COLLEGE OF PHARMACY GUIDED BY: Dr. (Mrs.) SHRUTI WAGLE

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Parkinson's disease [PD] is one of the most common neurodegenerative disorders. A progressive disease of the nervous system marked by tremor, muscular rigidity, and slow, imprecise movement, chiefly affecting middle-aged and elderly people. It is associated with degeneration of the basal ganglia of the brain and a deficiency of the neurotransmitter dopamine.

WHAT IS PARKINSON’S DISEASE?

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Non motor symptoms:1- Dysautonomia2-nocturia3-constipation4-dementia5-Orthostatic hypotension

WHAT ARE THE SYMPTOMS?

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Drug affecting dopaminergic system in brain:

1- Dopa precursor: Levodopa2- Peripheral decarboxylase inhibitor: carbidopa3- Dopaminergic agonist: Bromocriptin 4- MAO-B inhibitor: Salagiline5-COMT inhibitor: Entacapone

DRUG TREATMENT….(Already in use)

Drug affecting cholinergic system in brain:

1-Anti-cholinergics: Bipiriden2-Anti-histamins: Orphenadrine

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1. A2A antagonists Tozadenant

2. Perampanel

3. Duodopa gel is a combination of levodopa and carbidopa [ratio 4:1] in a gel for continuous intestinal infusion in advanced Parkinson's disease with severe motor fluctuations.4.Comt Inhibitor Nebicapone 5.Mao B Inhibitor Safinamide

NEW DRUG TREATMENT……..

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ROLE OF SURGERY IN PARKINSON’S DISEASE......

1. Deep brain stimulation [DBS] DBS is a neurosurgical procedure involving the implantation of a medical device called a brain pacemaker. which sends electrical impulses, through implanted electrodes, to specific parts of the brain[brain nucleus] for the treatment of movement and affective disorders.

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In Parkinson's disease, a part of the brain called the globuspallidus is overactive. This causes a decrease in the activity of a different part of the brain that controls movement. In a pallidotomy, the surgeon destroys a tiny part of the globuspallidus by creating a scar.

2. Pallidotomy

ROLE OF SURGERY IN PARKINSON’S DISEASE......

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AYURVEDIC TREATMENT

1. Turmeric Juice

2. Ginger Juice

3. Garlic Juice

4. Lemon Juice

5. Honey

6. Apple Cider Vinegar with Mother

2. PRX002

VACCINATION

1. PD01A

AYURVEDIC TREATMENT AND VACCINES…

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Gene therapy in Parkinson's disease consists of the creation of new cells that produce a specific neurotransmitter (dopamine)

Gene therapy in Parkinson's disease

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Stem-cell therapy is the use of stem cells to treat or prevent a disease or condition.Bone marrow transplant is the most widely used stem-cell therapy.

STEM-CELL THERAPY…..

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Parkinson's disease is a relatively common, progressive, movement disorder. Drugs only provide symptomatic relief and give most patient an additional 3-6 years of happier and productive life. Although there is no cure, there are several management options for the early treatment of Parkinson’s disease. Conventional drug therapy is more effective and economically beneficial than new drug thearapies. As the disease progresses, further treatment options are available; however, the management of late-stage motor complications and non-motor symptoms remains particularly challenging and will benefit from further clinical research.

CONCLUSION?

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REFERENCES:

1- World journal of pharmaceutical research “TREATMENT OF PARKINSON’S DISEASE” volume 4,issue 8, 804-818. 2.http://www.oxforddictionaries.com/definition/english/Parkinson's-disease. 3.GBD 2013 Mortality and Causes of Death, Collaborators [17 December 2014]. "Global, regional, and national age-sex specific all-cause and cause-specific mortality for 240 causes of death, 1990–2013: a systematic analysis for the Global Burden of Disease Study., 2013; 385: 117–71. 4.http://www.prokerala.com/health/parkinsons-disease/ayurveda-to-treat-parkinsons-disease.php. 5.http://herbaldaily.in/health_Benefits_haldi.html.

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AT H N K Y O U

ANY QUESTION….?