ISO/IEC 27001:2005

Certificate No: IS 567140

1

Mark De Simone

The Medicine Digital Network Ecosystem

Transforming Economies throughthe ‘CAPITULATION’ of obsolete health models

(Schumpeter was correct on innovation)

∂

Health Education/

Literacy

Health Enabling

Environment

Culture and NormsChange

Healthy Living Re-investment in Health

IncreasedProductivity Increased

Consumption

IncreasedInvestment

MaximizeHealthy

Life-years

Initiate InvestmentIn health

Healthy PopulationCreating…

EconomicGrowth

3 Aegate Confidential

0

5

10

15

20

25

INDIA CHINA

ECONOMIC BURDEN OF NCD IN INDIA AND CHINA ALONE

WILL REACH $ 28 TRILLION BY 2030

MENTAL ILLNESS

CANCER

CHRONIC

OBSTRUCTIVEPULMONARY

CARDIO VASCULAR

DIABETES

4.6

23

Econom

ic B

urd

en o

f N

CD

, 2012-2

030,$

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Aegate Confidential4

5

STRUGGLING HEALTH SYSTEMS

PHARMACEUTICAL INDUSTRY VALUE CHAIN

Aegate Confidential6

THE BIG ‘SQUEEZE’

The big opportunity

INNOVATION IS THE ONLY WAY

7

INNOVATION, CAPITULATION AND SCHUMPETER

€/Unit Of ServiceLog

Time

1

0.1

0.01

0.001

0.0001

0.00001

0.000001

100 Yrs 50 Yrs 20 Yrs 15 Yrs 10 Yrs

Western Union

Bell

NOKIA

?

APPLE

Aegate Confidential8

9

PHARMACEUTICALINDUSTRY

PHARMACIES,PHARMACISTS, DISPENSING

PHYSICIANS OR NURSES

HEALTHCAREPROVIDERS AND

INSURERS

WHOLESALERS

REGULATORS

ACADEMIA AND RESEARCH

ORGANISATIONS

A PERVASIVE PLATFORM TO INNOVATE WITHOUT

BOUNDARIES

Aegate Confidential10

THE FRANCIS CRICK INSTITUTE: THE POSSIBLE FUTURE IN HEALTH INNOVATION

11

A VIRTUOUS CYCLE: INVESTING IN HEALTHIS KEY TO SOCIO-ECONOMIC GROWTH

PRECISION MEDICINE

BETTER OUTCOME

AND BETTER VALUE

GREATER INSIGHT

INTO PATIENTS

MORE EFFICIENT HEALTH

DELIVERY

ECONOMIC DEVELOPMENT

GREATER INNOVATION INVESTMENT

MAXIMISING HEALTHY

LIFE YEARS

ENABLED BY THE DIGITAL MEDICINENETWORK ECOSYSTEM

The Falsified Medicines Directive will link

12

manufacturers

10 billion prescription medicine packs across Europe

500 million people

177,000 pharmacies455,000 pharmacists

2,500 manufacturers

Aegate Public

13

PharmaceuticalCompanies

Patient

MedicinesPharmacy

Aegate Public

THE VIRTUOUS CIRCLE

14 Aegate Confidential

Aegate: transforming how we protect and inform patients. Partnering with our Ecosystem Partners to provide a Real Time platform with value services for

People, for the Industry, for Pharmacies, for Distributors and for Health Care Providers