Afri-Vape: Changes the way we treat colds and flu, by Afrigetics Botanicals

PowerPoint Presentation

Click here to begin

OUR INNOVATIONChanges the way we treat respiratory infections++PELARGONIUM

EUCALYPTUS

Click on the below icons to go to section

Click on the buttons to navigateBackHomeNext

VAPE

PELARGONIUM

The treatable conditionsHow does it treat the mentioned conditionsClinical backgroundSuccess storyClick on the below icons to go to section

BackHomeNext

Click on the buttons to navigate

CLINICAL BACKGROUND

1. Witte K, Koch E, Volk H-D, Wolk K, Sabat R. The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes. PLOS ONE 2015;1-13. | DOI:10.1371/journal.pone.0138075 PELARGONIUMPelargonium species are indigenous to areas of Southern Africa and are highly valued by traditional healers for their curative properties 1In South Africa, polyphenol-rich herbal preparations are made up from roots of Pelargonium sidoides - traditionally used to treat respiratory and gastrointestinal infections, dysmenorrhea, and hepatic disorders 1Inspired by the healing of his tuberculosis, Charles Henry Stevens introduced this phytomedical drug to England already in 1897 1


BACK TO PELARGONIUM

1. Witte K, Koch E, Volk H-D, Wolk K, Sabat R. The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes. PLOS ONE 2015;1-13. | DOI:10.1371/journal.pone.0138075 CLINICAL BACKGROUND

More than seven decades later, a special ethanolic extract of Pelargonium sidoides roots, EPs 7630, was finally developed 1This extract is approved today for the therapeutic use in patients with acute bronchitis 1In addition, it was shown to be effective in clinical trials with patients suffering from tonsillopharyngitis, rhinosinusitis, common cold or COPD 1PELARGONIUM


BACK TO PELARGONIUM


Success Story

GERMANYUsed as a cough syrup70M Euro turnover in 2007

PELARGONIUM

BACK TO PELARGONIUM

THE TREATABLE CONDITIONS

PELARGONIUMSINUSITISInflammation of the sinuses, most commonly caused by a viral or bacterial infection or by an allergy

COLDSAcute, self-limited viral infection causing upper respiratory symptoms (ie cough, sore throat, etc.)

COUGHSSudden, forceful expulsion of air from the lungs to clear material from the airways and to protect the lungs from particles that have been inhaled

ALLERGIC ASTHMAType I reactions underlie atopic disorders develop < 1 h after exposure to antigen


BACK TO PELARGONIUM


PELARGONIUMRHINITISInflammation of the nasal mucous membrane

PHARYNGITISSore throat is pain in the posterior pharynx that occurs with or without swallowingLARYNGITISInflammation of the voice box (larynx)

PNEUMONIAAcute inflammation of the lungs caused by infection

BRONCHITISInflammation of the tracheobronchial tree, commonly following a URI, the cause is almost always a viral infection


BACK TO PELARGONIUM


PELARGONIUMHOW DOES IT TREAT THE MENTIONED CONDITIONS

Pelargonium has been shown to have a three-way effect:Click on the below icons to go to section

BACK TO PELARGONIUM

PELARGONIUMPelargonium has been shown to have a three-way effect:The Pelargonium Sidoides extract prevents bacteria from attaching to cells in mucous membranes. 1Pelargonium sidoides extracts inhibit the adherence of bacteria such as Streptococcus pyogenes and Helicobacter pylori to epithelial cells in vitro.

Furthermore, ciliated cells isolated from the nasal epithelium enhanced their ciliary beat frequency in the presence of these extracts, which should allow a better removal of excess mucous and bacteria.1. Witte K, Koch E, Volk H-D, Wolk K, Sabat R. The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes. PLOS ONE 2015;1-13. | DOI:10.1371/journal.pone.0138075


BACK TO PELARGONIUM

PELARGONIUMPelargonium has been shown to have a three-way effect:Similarly, Pelargonium Sidoides prevents viruses from attaching to the mucous membrane cells and stimulates the bodys immune system in such a way that both bacteria and viruses are prevented from multiplying. 1In vitro, the extracts show efficacy against cellular infections with influenza virus, HSV, EMCV, RSV, coronavirus, parainfluenza virus, and coxsackie virus, and this appears to be mainly mediated indirectly by inhibition of virus attachment and spreading.1. Witte K, Koch E, Volk H-D, Wolk K, Sabat R. The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes. PLOS ONE 2015;1-13. | DOI:10.1371/journal.pone.0138075


BACK TO PELARGONIUM

PELARGONIUMPelargonium has been shown to have a three-way effect:The extract acts as an expectorant, allowing the body to expel contaminated mucous, making conditions less suitable for the multiplication of the bacteria and viruses can only find animal data.The three-way effect attacks the acute infection at its root, the stabilisation of the immune system prevents a re-infection and the vicious circle of infection, a short recovery phase and new infection is broken.


BACK TO PELARGONIUM

EUCALYPTUSThe treatable conditionsHow does it treat the mentioned conditionsClinical backgroundHow and where is it used todayClick on the below icons to go to section


1.Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):33-47. 2.Bapista EB , Zimmermann-Franco D,Lataliza AAB, Raposo NRB. Chemical composition and antifungal activity of essential oil from Eucalyptus smithii against dermatophytes Revista da Sociedade Brasileira de Medicina Tropical 2015; 48(6):746-752 3. Ben Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc C, Abderraba M, et alEucalyptus oleosa Essential Oils: Chemical Composition and Antimicrobial and Antioxidant Activities of the Oils from Different Plant Parts (Stems, Leaves, Flowers and Fruits). Molecules 2011;16:1695-1709.

EUCALYPTUSCLINICAL BACKGROUND

Eucalyptus oil (EO) has antibacterial, antiviral, and antifungal components and a long history of use against the effects of colds, influenza, other respiratory infections, rhinitis, and sinusitis. 1

Although most of the plants are native to Australia and Tasmania, they have been successfully introduced worldwide and are cultivated in many other countries. 3

The genus Eucalyptus belongs to the Myrtaceae family, which comprises approximately 130 genera and 4,000 species. 2

More than 300 species of Eucalyptus contain volatile oils in their leaves. 2


BACK TO EUCALYPTUS

CLINICAL BACKGROUND

1.Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):33-47.EUCALYPTUSEucalyptus oil (EO) and its major component, 1,8-cineole, have antimicrobial effects against many bacteria, including: 1Mycobacterium tuberculosis Methicillin-resistant Staphylococcus aureus (MRSA)VirusesAnd Fungi (including Candida)

Surprisingly for an antimicrobial substance, there are also immune-stimulatory, anti-inflammatory, antioxidant, analgesic, and spasmolytic effects 1

More recently, the biochemical details behind these effects have been clarified 1


BACK TO EUCALYPTUS

1.Bapista EB , Zimmermann-Franco D,Lataliza AAB, Raposo NRB. Chemical composition and antifungal activity of essential oil from Eucalyptus smithii against dermatophytes Revista da Sociedade Brasileira de Medicina Tropical 2015; 48(6):746-752 2.Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):33-47.3. Ben Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc C, Abderraba M, et al Eucalyptus oleosa Essential Oils: Chemical Composition and Antimicrobial and Antioxidant Activities of the Oils from Different Plant Parts (Stems, Leaves, Flowers and Fruits). Molecules 2011;16:1695-1709.The essential oils from Eucalyptus plants possess biological properties such as antibacterial, antifungal, antitumor, and insecticidal properties, and they are used in spices, cosmetic formulations, and pharmaceuticals worldwide 1,2

In the cosmetics industry Eucalyptus essential oil is used in detergents , toiletries and little employed in perfumes and as a flavoring agent in food 3

In addition, the essential oils of Eucalyptus species possesses important biological activities including diaphoretic, disinfectant, antimalarial, antiseptic, analgesic, anti-inflammatory, antibacterial ,expectorant and antioxidant properties 3How and where is it used today

EUCALYPTUS


BACK TO EUCALYPTUS


INHALED EUCALYPTUS OIL VAPOUR IS A DECONGESTANT AND TREATMENT FOR BRONCHITIS

From a pharmaceutical perspective:Application by either vapor inhalation or oral route provides benefit for both purulent and non-purulent respiratory problems, such as bronchitis, asthma, and chronic obstructive pulmonary disease (COPD). 1 1. Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):EUCALYPTUS


BACK TO EUCALYPTUS

HOW DOES IT TREAT THE MENTIONED CONDITIONS


EUCALYPTUSClick on the below icons to go to sectionANTI-BACTERIALANTI-VIRAL EFFECTS

ANTI-FUNGALANTI-INFLAMMATORY

BACK TO EUCALYPTUS

Various Eucalyptus extract have shown strong antifungal activity against Candida albicans, certain Aspergillus species as well as Mycosporum and Trichophyton species. 1 a p40,2 a p7461.Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):33-47 2. Ben Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc C, Abderraba M, et al Eucalyptus oleosa Essential Oils: Chemical Composition and Antimicrobial and Antioxidant Activities of the Oils from Different Plant Parts (Stems, Leaves, Flowers and Fruits). Molecules 2011;16:1695-1709.

EUCALYPTUS


Click on the below icons to go to sectionANTI-BACTERIALANTI-VIRAL EFFECTS


BACK TO EUCALYPTUS

Mild antiviral effects of E globulus oil on Adenovirus. 1 a p391.Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):33-47 2. Ben Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc C, Abderraba M, et al Eucalyptus oleosa Essential Oils: Chemical Composition and Antimicrobial and Antioxidant Activities of the Oils from Different Plant Parts (Stems, Leaves, Flowers and Fruits). Molecules 2011;16:1695-1709.

EUCALYPTUS


Click on the below icons to go to sectionANTI-BACTERIALANTI-VIRAL EFFECTS


BACK TO EUCALYPTUS

1.Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):33-47 2. Ben Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc C, Abderraba M, et al Eucalyptus oleosa Essential Oils: Chemical Composition and Antimicrobial and Antioxidant Activities of the Oils from Different Plant Parts (Stems, Leaves, Flowers and Fruits). Molecules 2011;16:1695-1709.Effects on pathogenic bacteria in the respiratory tract more active against Gram positive than Gram negative organisms. 1, 2Table 3: Microbial Sensitivities to EucalyptusEffect of Eucalyptus on common respiratory pathogensMicrobeSensitivityS. aureusModerate E. globulusHigh E. sideroxylon, E. torquataNone E. globulusLittle to none - E. globulusHaemophilus influenzaHigh - E. globulusH. parainfluenzaHigh - E. globulusMycobacterium tuberculosisHigh improved symptoms and negative sputum culture reported; no studies found on the bacterial strain directly - E. globulusK. pneumoniaMild - E. sideroxylon, E. torquataNone - E. globulusLittle to none - E. globulusS. pneumoniaeMild - E. globulusS. pyogenesLittle - E. globulus

EUCALYPTUS


Click on the below icons to go to sectionANTI-FUNGAL

ANTI-VIRAL EFFECTS

ANTI-INFLAMMATORYANTI-BACTERIAL

BACK TO EUCALYPTUS

1.Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):33-47 2. Ben Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc C, Abderraba M, et al Eucalyptus oleosa Essential Oils: Chemical Composition and Antimicrobial and Antioxidant Activities of the Oils from Different Plant Parts (Stems, Leaves, Flowers and Fruits). Molecules 2011;16:1695-1709.Anti-inflammatory and analgesic qualities decreases certain cytokines reducing inflammation. 1Table 2. Immunomodulatory Effects of Eucalyptus Oil and 1,8-CineoleEucalyptus Oil1,8-CineoleIncreases phagocytic activity and number of monocytes/macrophages 7Inhibits or reduces TNF-, IL-1, IL-4, IL-5, IL-6, IL-8, LTB4, PGE2, TxB2 9,10,13Decreases significantly or inhibits IL-4, IL-6, TNF- and NF-B when inflammation present 7Affects monocytes/macrophages more than other leukocytes 13No influence of IL-2, IL-10, INF- 7Decreases localization of Egr-1 14Significantly lowers inflammation cell infiltrates such as neutrophils 8,17Had no effect on NF-B 14Decreases airway mucin secretion of tracheal and bronchiole epithelium 8E0/5-FU combination inhibited myelotoxicity and increased phagocytic activity of granulocytes 7

EUCALYPTUS


Click on the below icons to go to sectionANTI-FUNGAL

ANTI-VIRAL EFFECTS

ANTI-BACTERIAL

ANTI-INFLAMMATORY

BACK TO EUCALYPTUS

CASE STUDYCombining Eucalyptus Oil with Pelargonium (Sidoides or Reniforme)

SUMMARYEnhanced pharmacological effect by producing synergy

EXPLANATIONEucalyptus oil and Pelargonium Sidoides/Reniforme extract, both have anti-viral, anti-bacterial and anti-fungal properties, but act on different aerobic and anti-aerobic organisms, and on a different pharmacological basis (direct and indirect). 1,2,3

The vasodilation effect of Eucalyptus is providing air and oxygen to blocked sinus areas and is preventing anaerobic bacterial effect just with this action alone.SUMMARY OF THE HERB FORMULATION

1.Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):33-472. Ben Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc C, Abderraba M, et al Eucalyptus oleosa Essential Oils: Chemical Composition and Antimicrobial and Antioxidant Activities of the Oils from Different Plant Parts (Stems, Leaves, Flowers and Fruits). Molecules 2011;16:1695-1709.3.3. Witte K, Koch E, Volk H-D, Wolk K, Sabat R. The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes. PLOS ONE 2015;1-13. | DOI:10.1371/journal.pone.0138075


CASE STUDYEnhancing the absorption and effect on the body of the herb formulation of Pelargonium Sidoides / Reniforme and/or Eucalyptus, by mouth or nasal passage, using a medical device (battery-powered vaporiser, Electrical vaporiser or nebuliser/pump)

SUMMARYEnhanced pharmacokinetic effect by producing a formulation of the herb Pelargonium Sidoides/Reniforme, with/or without Eucalyptus, for inhalation purposes

EXPLANATIONEucalyptus oil is well absorbed by inhalation and has a direct vasodilation effect (within less than 120 seconds of inhalation, results not published), and therefore also has a faster onset effect on aerobic infections in the upper nasal and respiratory areas.

Pelargonium Sidoides / Reniforme has a low bioavailability (2%-6%) and will have an enhanced by inhalation, to provide a quicker pharmacological effect.

Both pharmacological active components are now provided to the site of infections at an enhanced rate and at higher effective concentrations, than oral administration.SUMMARY OF THE HERB FORMULATION

1.Sadlon AE, Lamson DW. Immune-Modifying and Antimicrobial Effects of Eucalyptus Oil and Simple Inhalation Devices. Alternative Medicine Review 2010;15(1):33-472. Ben Marzoug HN, Romdhane M, Lebrihi A, Mathieu F, Couderc C, Abderraba M, et al Eucalyptus oleosa Essential Oils: Chemical Composition and Antimicrobial and Antioxidant Activities of the Oils from Different Plant Parts (Stems, Leaves, Flowers and Fruits). Molecules 2011;16:1695-1709.3.3. Witte K, Koch E, Volk H-D, Wolk K, Sabat R. The Pelargonium sidoides Extract EPs 7630 Drives the Innate Immune Defense by Activating Selected MAP Kinase Pathways in Human Monocytes. PLOS ONE 2015;1-13. | DOI:10.1371/journal.pone.0138075


VAPEMedicinal vaping has a bright future!Why VapeWhat are the future trends for Vape/VapingClick on the below icons to go to section


VAPEPatient convenienceEasy to carry aroundMore cost effective than a nebulizerMobileRe-usableLess messy and uncomfortable than syrups/drops

Medical benefitsActs directly at the site of infectionHas a faster onset rate than oral administrationHigher concentration to the site of infectionQuicker recovery timeBetter patient complianceFashionable medication


Why VapeBACK TO VAPE

VAPEWhat are the future trends for Vape/Vaping

There is growing evidence that Essential Oils (EOs) in vapour phase are effective antimicrobial systems and that they do have advantages over the use of EOs in liquid phase such as an increase in antibacterial activity and use at lower concentrations. 1


1.Laird K, Phillips C.Vapour phase: a potential future use for essential oils as antimicrobials? Letters in Applied Microbiology 2011; 54, 169174.BACK TO VAPE

VAPEMedicinal vaping has a bright future!Since 2008, the number of U.S. vape shops has grown to about 8,500, and the sale of electronic cigarettes and supplies climbed to $3.5 billion, according to Wells Fargo Securities analyst Bonnie Herzog. She expects U.S. use of e-cigarettes and vaporizers to overtake combustible cigarettes in 10 years. Business Insider, Jilian Mincer, Jul. 29, 2015


BACK TO VAPE

STORY OVERVIEWWHY DO WE EXISTWho are weWhose behind it allWhat do we doExisting offeringsHow do we engage our communitiesHow we workOUR INNOVATION, YOUR OPPORTUNITYPelargonium sidoides/reniformeEucalyptusVapeOUR OFFERING, YOUR OPPORTUNITYWhats in it for you?


Our offering,YOUR OPPORTUNITY


ONE MONTH SUPPLY BATTERY-POWERED VAPORISERA disposable, pre-loaded one month supply e-cigarette with enclosed battery.

VIAL FOR NEBULISER

Vial of the herb that can be branded by you and sold with a nebuliser.

RE-USABLE ELECTRONIC VAPE

Re-usable e-cigarette into which the e-liquid herb formulation can be placed Afrivape.

OUR OFFERING, YOUR OPPORTUNITYAvailable product variations of Pelargonium with/without Eucalyptus:


WHY OUR OFFERING WORKS

USEIn medical and/or inhalation device, to be inhaled through the mouth and nasal passages into lungs for the purposes of treating medical respiratory conditions.

WHY?Inhalation of Pelargonium Sidoides at the site of infection has a faster onset rate than oral administrationExtracts of Pelargonium have been proven to reduce the duration and severity of colds, especially relating to bronchial infections of the lungs 1,2,3 Ultimately makes the process of taking medication more convenient 1.Lizogup VG, Riley DS, Heger M. Efficacy of apelargoniumsidoidespreparation in patients with the common cold: a randomized, double blind, placebo-controlled clinical trial. Explore (NY).2007 Nov-Dec;3(6):573-84.2.2. Timmer A, Gunther J, Motschall E, et al. Pelargonium sidoides extract for treating acute respiratory tract infections. Cochrane Database Syst Rev.2013 Oct 22;10:CD006323. doi: 10.1002/14651858.CD006323.pub3. 3.Matthys H, Pliskevitch DA, Bondarchuk OM, Malek FA, Triabnek M, Kieser M. Randomised, double-blind, placebo-controlled trial of EPs 7630 in adults with COPD. Respiratory Medicine 2013; 107: 691-e701


WHY OUR OFFERING WORKS

vsvsDROPS Needs to get into blood stream first (ie via GIT system), messy & time-consuming

SYRUPSNeeds to get into blood stream first (ie via GIT system), messy, difficult to measure & time-consuming

NEBULIZERS Inconvenient, uncomfortable, expensive & time-consuming

INTRAVENOUS METHODS Painful, inconvenient, uncomfortable, expensive & time-consuming


vsvsVAPE = Convenient and cost effective method acting right at the infected site


WHATS IN IT FOR YOU?We are offering you white labelling opportunitySole Patent licencing in the countryExtended current product range or variationsNew product offerings


WHATS IN IT FOR YOU?Targeting the herbal-inclined consumerOpportunity to further research of this multi-purpose herb formulationOpportunity to be leaders in medicinal Vaping Be at the forefront of a new medical device offering

Click on the buttons to navigateBackHome

THANK YOU

Health & Medicine

Afri-Vape: Changes the way we treat colds and flu, by Afrigetics Botanicals