Alabama Neuroscience Blueprint Core Center

Core E

In Vivo Physiology & Phenotyping

Core Directors: J. Michael Wyss and Tim R. Nagy

In Vivo Physiology & Phenotyping

• Blood Pressure

• Heart Rate

• EEG/new Non-invasive

Seizure Detection

• Learning and Memory

• Body Composition

• Metabolism

Tinsley Harrison Tower 9th Floor

Volker Hall G008

Blood Pressure, Heart Rate, and EEG

Direct measurements

• Telemetry (Implantable devices):– Blood pressure– Heart rate– EEG

• Surgery

• Animal in home cage

• Signals relayed via a base under cage

Indirect measurements• Tail cuff measurements:

– Blood pressure– Heart rate

• No surgery• Placed in restraint

• TO BE ADDED IN LATE 2008Non-invasive seizure detection module

Learning and Memory

Intellicage system

• Screening for behavioral and cognitive malfunctions in mice living in groups.

• Allows normal social behavior

• Transponders can track individual behavior.

• Short and long-term studies possible

• Other learning and memory tests– Grip strength

– Mazes– Rotorod

• Contact Thomas van Groen 4-5940

Body composition

Dual-energy X-ray absorptiometry

• Lunar Piximus

• Measures fat mass, lean mass, bone mineral content and density

• Need anesthesia

Rat DXA

Quantitative Magnetic Resonance

• Echo Medical

• Fat and lean mass

• Rats, mice, tissues, biopsies

• No anesthesia

Energy ExpenditureFeeding and Activity

• Energy expenditure • Detailed food intake

– Meal size– Meal frequency– Timing of meals

• Activity– Locomotor– Fine movements– Different areas

Directors: J. Michael WyssTim R. Nagy

Contact personnel:

Blood pressure: Ning Peng 4-5940Behavioral: Thomas van Groen 4-5940Body composition/Metabolism: Maria Johnson 4-4008

Core EIn Vivo Physiology & Phenotyping