16
Interciencia 2013;4(3):105 - 112 Síntomas neuropsiquiátricos en Parkinson 105 ARTÍCULO ORIGINAL Alteraciones neuropsiquiátricas de pacientes con deterioro cognitivo leve y demencia asociada a la enfermedad de Parkinson 5PS[VU *\Z[VKPV 1-3 :OLPSH *HZ[YV:\HYLa ,KLY /LYYLYH7tYLa +H]PK 3PYH 1-3 9VZH 4VU[LZPUVZ ,YPR .\L]HYH:PS]H 3PaH 5|La KLS 7YHKV 8 5VYH 9VQHZ 8 . RESUMEN 3VZ ZxU[VTHZ UL\YVWZPX\Pm[YPJVZ :57 ZVU MYLJ\LU[LZ LU SH LUMLYTLKHK KL 7HYRPUZVU ,7 PUKLWLUKPLU[LTLU[L KLS LZ[HKV JVNUP[P]V KLS WHJPLU[L WLYV ZVU TmZ MYLJ\LU[LZ ` ZL]LYVZ LU LZ[HKPVZ H]HUaHKVZ KL SH LUMLYTLKHK Objetivos: *VUVJLY SH MYLJ\LUJPH ` [PWV KL :57 TLKPHU[L SH HWSPJHJP}U KL \UH LZJHSH KL TLKPJP}U NSVIHS LU WHJPLU[LZ JVU ,7 Pacientes y métodos: 7YVZWLJ[P]HTLU[L ZL MVYTHYVU [YLZ NY\WVZ! WHJPLU[LZ JVU KPHNU}Z[PJV KL ,7 JVNUP[P]HTLU[L UVYTHSLZ ,7*5 WHJPLU[LZ JVU KL[LYPVYV JVNUP[P]V SL]L HZVJPHKV H ,7 ,7+*3 ` WHJPLU[LZ JVU KLTLUJPH HZVJPHKH H ,7 +,7 :PN\PLUKV \U VYKLUHKV WYV[VJVSV SVZ PUKP]PK\VZ M\LYVU ZVTL[PKVZ H L]HS\HJPVULZ Z\JLZP]HZ KL JYPIHKV KPHNU}Z[PJV ` [PWV KL KL[LYPVYV JVNUP[P]V S\LNV KL SVZ J\HSLZ M\LYVU L]HS\HKVZ TLKPHU[L LS 5L\YVWZ`JOPH[YPJ 0U]LU[VY` 570 Resultados: 3VZ ZxU[VTHZ TmZ JVT\ULZ LU WHJPLU[LZ JVU ,7*5 ` ,7+*3 M\LYVU! KLWYLZP}U ` YLZWLJ[P]HTLU[L HUZPLKHK ` YLZWLJ[P]HTLU[L ` HWH[xH ` YLZWLJ[P]HTLU[L" TPLU[YHZ X\L LU WHJPLU[LZ JVU +,7 SVZ ZxU[VTHZ TmZ JVT\ULZ M\LYVU! HUZPLKHK WYVISLTHZ KLS Z\L|V ` HWH[xH Conclusiones: +LWYLZP}U HWH[xH ` HUZPLKHK ZVU SVZ [YLZ ZxU[VTHZ TmZ JVTUTLU[L YLWVY[HKVZ LU WHJPLU[LZ JVU ,7*5 ,7+*3 ` +,7 JVU WYL]HSLUJPHZ WHYH JHKH ZxU[VTH KL HWYV_PTHKHTLU[L KL [VKVZ SVZ JHZVZ JVU L_JLWJP}U KL KLWYLZP}U LU +,7 WYLZLU[L LU TLUVZ KL SH TP[HK KL WHJPLU[LZ 5\LZ[YV LZ[\KPV SSHTH SH H[LUJP}U WHYH HUHSPaHY [VKV LS LZWLJ[YV KL SHZ JHYHJ[LYxZ[PJHZ JVUK\J[\HSLZ LU ,7 KLZKL LZ[HKPVZ [LTWYHUVZ Palabras clave: *VNUPJP}U +LTLUJPH ,UMLYTLKHK KL 7HYRPUZVU :xU[VTHZ UL\YVWZPX\Pm[YPJVZ <UPKHK KL +PHNU}Z[PJV KL +L[LYPVYV *VNUP[P]V ` 7YL]LUJP}U KL +LTLUJPH *SxUPJH 0U[LYUHJPVUHS 3PTH 7LY <UPKHK KL 0U]LZ[PNHJP}U *SxUPJH 0U[LYUHJPVUHS 3PTH 7LY :LY]PJPV KL 5L\YVSVNxH *SxUPJH 0U[LYUHJPVUHS 3PTH 7LY :LY]PJPV KL 5L\YVSVNxH KL SH *VUK\J[H 0UZ[P[\[V 5HJPVUHS KL *PLUJPHZ 5L\YVS}NPJHZ 3PTH 7LY <UPKHK KL 7YV`LJ[VZ KL 0U]LZ[PNHJP}U 0UZ[P[\[V KL :HS\K KLS 5P|V 3PTH 7LY :LY]PJPV KL 4LKPJPUH KL 9LOHIPSP[HJP}U *SxUPJH 0U[LYUHJPVUHS 3PTH 7LY +LWHY[HTLU[V KL 4LKPJPUH /VZWP[HS :HU 1\HU KL 3\YPNHUJOV 3PTH 7LY :LY]PJPV KL 5L\YVSVNxH *SxUPJH 4HPZVU KL :HU[t 3PTH 7LY Cómo citar el artículo: Custodio N, Castro-Suarez S, Herrera-Pérez E, Lira D, Montesinos R, Guevara-Silva E, Núñez L, Rojas N. Alteraciones neuro-psiquiátricas de pacientes con deterioro cognitivo leve y demencia asociada a la enfermedad de Parkinson. Interciencia. 2013;4(3): 105-112.

Alteraciones neuropsiquiátricas de pacientes con deterioro cognitivo leve y demencia asociada a la enfermedad de Parkinson

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Articulo desarrollado por Nilton Custodio, Sheila Castro-Suarez, Eder Herrera-Pérez, David Lira, Rosa Montesinos, Erik Guevara-Silva, Liza Núñez del Prado y Nora Rojas para la revista Interciencia.

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Page 1: Alteraciones neuropsiquiátricas de pacientes con deterioro cognitivo leve y demencia asociada a la enfermedad de Parkinson

Interciencia 2013;4(3):105 - 112 Síntomas neuropsiquiátricos en Parkinson 105

ARTÍCULO ORIGINAL

Alteraciones neuropsiquiátricas de pacientes con

deterioro cognitivo leve y demencia asociada a la

enfermedad de Parkinson

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RESUMEN

3VZ�ZxU[VTHZ�UL\YVWZPX\Pm[YPJVZ��:57��ZVU�MYLJ\LU[LZ�LU�SH�LUMLYTLKHK�KL�7HYRPUZVU��,7���PUKLWLUKPLU[LTLU[L�KLS�LZ[HKV�JVNUP[P]V�KLS�WHJPLU[L��WLYV�ZVU�TmZ�MYLJ\LU[LZ�`�ZL]LYVZ�LU�LZ[HKPVZ�H]HUaHKVZ�KL�SH�LUMLYTLKHK�Objetivos:� *VUVJLY� SH� MYLJ\LUJPH� `� [PWV� KL� :57�� TLKPHU[L� SH� HWSPJHJP}U� KL� \UH� LZJHSH� KL� TLKPJP}U� NSVIHS� LU�WHJPLU[LZ�JVU�,7��Pacientes y métodos:�7YVZWLJ[P]HTLU[L�ZL�MVYTHYVU�[YLZ�NY\WVZ!����WHJPLU[LZ�JVU�KPHNU}Z[PJV�KL�,7�JVNUP[P]HTLU[L�UVYTHSLZ��,7�*5������WHJPLU[LZ�JVU�KL[LYPVYV�JVNUP[P]V�SL]L�HZVJPHKV�H�,7��,7�+*3���`����WHJPLU[LZ�JVU�KLTLUJPH�HZVJPHKH�H�,7��+,7���:PN\PLUKV�\U�VYKLUHKV�WYV[VJVSV��SVZ�PUKP]PK\VZ�M\LYVU�ZVTL[PKVZ�H�L]HS\HJPVULZ�Z\JLZP]HZ�KL�JYPIHKV��KPHNU}Z[PJV�`� [PWV�KL�KL[LYPVYV�JVNUP[P]V�� S\LNV�KL� SVZ�J\HSLZ�� M\LYVU�L]HS\HKVZ�TLKPHU[L�LS�5L\YVWZ`JOPH[YPJ�0U]LU[VY`��570���Resultados:�3VZ�ZxU[VTHZ�TmZ�JVT\ULZ�LU�WHJPLU[LZ�JVU�,7�*5�`�,7�+*3��M\LYVU!�KLWYLZP}U���������`��������YLZWLJ[P]HTLU[L���HUZPLKHK���������`��������YLZWLJ[P]HTLU[L��`�HWH[xH���������`��������YLZWLJ[P]HTLU[L�"�TPLU[YHZ�X\L�LU�WHJPLU[LZ�JVU�+,7��SVZ�ZxU[VTHZ�TmZ�JVT\ULZ�M\LYVU!�HUZPLKHK����� �����WYVISLTHZ�KLS�Z\L|V����������̀ �HWH[xH����������Conclusiones:�+LWYLZP}U��HWH[xH�̀ �HUZPLKHK�ZVU�SVZ�[YLZ�ZxU[VTHZ�TmZ�JVT�UTLU[L�YLWVY[HKVZ�LU�WHJPLU[LZ�JVU�,7�*5��,7�+*3�`�+,7��JVU�WYL]HSLUJPHZ�WHYH�JHKH�ZxU[VTH�KL�HWYV_PTHKHTLU[L������KL�[VKVZ�SVZ�JHZVZ��JVU�L_JLWJP}U�KL�KLWYLZP}U�LU�+,7��WYLZLU[L�LU�TLUVZ�KL�SH�TP[HK�KL�WHJPLU[LZ���5\LZ[YV�LZ[\KPV�SSHTH�SH�H[LUJP}U�WHYH�HUHSPaHY�[VKV�LS�LZWLJ[YV�KL�SHZ�JHYHJ[LYxZ[PJHZ�JVUK\J[\HSLZ�LU�,7�KLZKL�LZ[HKPVZ�[LTWYHUVZ�

Palabras clave: *VNUPJP}U��+LTLUJPH��,UMLYTLKHK�KL�7HYRPUZVU��:xU[VTHZ�UL\YVWZPX\Pm[YPJVZ�

���<UPKHK�KL�+PHNU}Z[PJV�KL�+L[LYPVYV�*VNUP[P]V�`�7YL]LUJP}U�KL�+LTLUJPH�����*SxUPJH�0U[LYUHJPVUHS��3PTH��7LY�����<UPKHK�KL�0U]LZ[PNHJP}U��*SxUPJH�0U[LYUHJPVUHS��3PTH��7LY�����:LY]PJPV�KL�5L\YVSVNxH��*SxUPJH�0U[LYUHJPVUHS��3PTH��7LY�����:LY]PJPV�KL�5L\YVSVNxH�KL�SH�*VUK\J[H��0UZ[P[\[V�5HJPVUHS�KL�*PLUJPHZ�5L\YVS}NPJHZ������3PTH��7LY�����<UPKHK�KL�7YV`LJ[VZ�KL�0U]LZ[PNHJP}U��0UZ[P[\[V�KL�:HS\K�KLS�5P|V��3PTH��7LY�����:LY]PJPV�KL�4LKPJPUH�KL�9LOHIPSP[HJP}U��*SxUPJH�0U[LYUHJPVUHS��3PTH��7LY�����+LWHY[HTLU[V�KL�4LKPJPUH��/VZWP[HS�:HU�1\HU�KL�3\YPNHUJOV��3PTH��7LY�����:LY]PJPV�KL�5L\YVSVNxH��*SxUPJH�4HPZVU�KL�:HU[t��3PTH��7LY��

Cómo citar el artículo: Custodio N, Castro-Suarez S, Herrera-Pérez E, Lira D, Montesinos R, Guevara-Silva E, Núñez L, Rojas N. Alteraciones neuro-psiquiátricas de pacientes con deterioro cognitivo leve y demencia asociada a la enfermedad de Parkinson. Interciencia. 2013;4(3): 105-112.

Page 2: Alteraciones neuropsiquiátricas de pacientes con deterioro cognitivo leve y demencia asociada a la enfermedad de Parkinson

Interciencia 2013;4(3):105 - 112Custodio N. et al.106

ARTÍCULO ORIGINAL

05;96+<**0Ô5

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Interciencia 2013;4(3):105 - 112 Síntomas neuropsiquiátricos en Parkinson 107

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Interciencia 2013;4(3):105 - 112Custodio N. et al.108

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* EP-CN vs. DEP p < 0,01 †�(3�'&/�YV��'(3�S�Ӻ�����BDI-II: Beck Depression Inventory–version II, MMSE: Mini Mental State Examination, ACE: Addenbroke’s Cognitive Examination.

Los resultados entre paréntesis corresponden a la desviación estándar (DS).

EdadGénero (F:M)

Educación (en años)Duración EP (en años)

Hoehn-YahrBDI-IIACE

63,9 (6,3)7:15

10,9 (2,5)6,2 (3,4)1,8 (0,6)12,3 (2,7)91,9 (3,3)

70,6 (8,2)7:11

10,1 (2,4)6,4 (2,7)2,1 (0,4)11,5 (4,3)84,3 (4,1)

NSNSNSNS

< 0,01*NS

< 0,001*†

71,4 (7,1)8:15

10,3 (2,6)8,8 (5,9)2,6 (0,3)12,2 (6,7)74,9 (4,6)

PEP-CNn = 22

EP-DCLn = 18

DEPN = 23

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Interciencia 2013;4(3):105 - 112 Síntomas neuropsiquiátricos en Parkinson 109

ARTÍCULO ORIGINAL

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Tabla 2. Puntuación promedio de los ítems del Neuropsychiatric Inventory (NPI) en todos los pacientes con enfermedad de Parkinson, según nivel de deterioro cognitivo y pacientes que muestran síntomas.

Ítem NPI

Delusiones

Alucinaciones

Agitación/agresividad

Depresión/disforia

Ansiedad

Euforia

Apatía

Desinhibición

Irritabilidad

Conducta motora aberrante

Problemas de sueño

Problemas de apetito

NPI TOTAL

EP-CN (n = 22)

TodosPuntos en NPI media (DS)0,43

(1,38)0,48

(1,53)0,58

(1,52)2,37

(2,65)2,23

(2,49)0,24

(1,11)1,41

(2,10)0,25

(0,93)1,12

(1,79)0,28

(1,27)1,34

(0,98)0,47

(0,36)9,64

(9,36)

Puntos en NPI media (DS)3,36

(2,79)2,90

(2,38)2,54 (227)3,46

(2,63)3,25

(2,56)2,25

(2,38)2,91

(2,49)2,12

(1,98)2,42

(1.12)2.78

(2,48)3,16

(2,45)2,56

(1,89)11,24

(10,43)

Porcentaje FRQ�13,����

N (% total)

2 (9,1)

2(9,1)

1 (4,5)

7(31,8)

6(27,3)

1(4,5)

4(18,2)

2(9,1)

4(18,2)

1(4,5)

2(9,1)

2(9,1)14

(63,6)

Pacientes con SNP TodosPuntos en NPI media (DS)1,25

(1,27)0.87

(1,45)0,67

(1,58)2,59

(2,08)2,81

(2,12)0,28

(1,23)1,98

(1,89)0,57

(1,12)1,25

(1,68)0,75

(1,43)1,45

(1,16)1,21

(0,76)12,13

(10,76)

Puntos en NPI media (DS)2,45

(2,13)2.06

(1,98)2,24

(2,18)2,17

(2,34)3,96

(2,71)2,23

(2,16)3,56

(2,54)2,28

(1,76)3,81

(2,37)2,16

(1,76)3,16

(1,76)2,68

(1,94)14,35

(11,56)

Porcentaje FRQ�13,����

N (% total)

4 (22,2)

3(16,6)

4(22,2)

3(16,6)

6(33,3)

3(16,6)

7(38,9)

3(16,6)

5(27,8)

3(16,6)

6(33,3)

4(22,2)

13(72,2)

Pacientes con SNP TodosPuntos en NPI media (DS)1,98

(3,56)1,99

(3,12)1.31

(2,23)1,56

(2,56)1,83

(2,71)0,18

(0,68)2,58

(3,59)0,46

(1,23)1,42

(2,47)1,32

(2,48)2,56

(3,67)1,97

(3,84)19,35

(20,43)

Puntos NPI

media (DS)4.96

(3,74)3,93

(3,42)2,98

(2,48)3,16

(2,88)3,17

(2,79)1,51(1,1)4,77

(3,49)2,46(2,1)3,53

(2,96)3,56(3,8)4,87

(3,71)4,14

(3,88)21,42

(20,54)

Porcentaje FRQ�13,����

N (% total)

6(26,1)

5(21,7)

3(13)

4(17,4)

5(21,7)

1(4,3)

8(34,8)

1(4,3)

3(13)

4(17,4)

8(34,8)

6(26,1)

17(73,9)

Pacientes con SNP

EP-DCL (n = 18) DEP (n = 23)

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Interciencia 2013;4(3):105 - 112Custodio N. et al.110

ARTÍCULO ORIGINAL

Tabla 3. Proporción de pacientes con SNP en pacientes con DEP.

DelusionesAlucinaciones

Agitación/agresividadDepresión/disforia

AnsiedadEuforiaApatía

DesinhibiciónIrritabilidad

Conducta motora aberranteProblemas de sueñoProblemas de apetito

Síntomaneuropsiquiátrico

5810414311498128

N

21,734.743,517,460,913,047,817,439,134,752,234.7

%

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Interciencia 2013;4(3):105 - 112 Síntomas neuropsiquiátricos en Parkinson 111

ARTÍCULO ORIGINAL

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Page 8: Alteraciones neuropsiquiátricas de pacientes con deterioro cognitivo leve y demencia asociada a la enfermedad de Parkinson

Interciencia 2013;4(3):105 - 112Custodio N. et al.112

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Correspondencia:

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Interciencia 2013;4(3):113-120 Neuropsychiatric Symptoms in Parkinson’s Disease 113

ORIGINAL ARTICLE

Neuropsychiatric disorders in patients with mild

cognitive impairment and dementia associated

with Parkinson’s disease

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ABSTRACT

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Key words:�*VNUP[PVU��+LTLU[PH��7HYRPUZVU»Z�KPZLHZL��5L\YVWZ`JOPH[YPJ�Z`TW[VT�

���<UPKHK�KL�+PHNU}Z[PJV�KL�+L[LYPVYV�*VNUP[P]V�`�7YL]LUJP}U�KL�+LTLUJPH�����*SxUPJH�0U[LYUHJPVUHS��3PTH��7LY�����<UPKHK�KL�0U]LZ[PNHJP}U��*SxUPJH�0U[LYUHJPVUHS��3PTH��7LY�����:LY]PJPV�KL�5L\YVSVNxH��*SxUPJH�0U[LYUHJPVUHS��3PTH��7LY�����:LY]PJPV�KL�5L\YVSVNxH�KL�SH�*VUK\J[H��0UZ[P[\[V�5HJPVUHS�KL�*PLUJPHZ�5L\YVS}NPJHZ��3PTH��7LY�����<UPKHK�KL�7YV`LJ[VZ�KL�0U]LZ[PNHJP}U��0UZ[P[\[V�KL�:HS\K�KLS�5P|V��3PTH��7LY�����:LY]PJPV�KL�4LKPJPUH�KL�9LOHIPSP[HJP}U��*SxUPJH�0U[LYUHJPVUHS��3PTH��7LY�����+LWHY[HTLU[V�KL�4LKPJPUH��/VZWP[HS�:HU�1\HU�KL�3\YPNHUJOV��3PTH��7LY�����:LY]PJPV�KL�5L\YVSVNxH��*SxUPJH�4HPZVU�KL�:HU[t��3PTH��7LY��

How to cite the article: Custodio N, Castro-Suarez S, Herrera-Pérez E, Lira D, Montesinos R, Guevara-Silva E, Núñez L, Rojas N. Neuropsychiatric disorders in patients ZLWK�PLOG�FRJQLWLYH�LPSDLUPHQW�DQG�GHPHQWLD�DVVRFLDWHG�ZLWK�3DUNLQVRQ·V�GLVHDVH��,QWHUFLHQFLD���������������������

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Interciencia 2013;4(3):113-120Custodio N. et al.114

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Interciencia 2013;4(3):113-120 Neuropsychiatric Symptoms in Parkinson’s Disease 115

ORIGINAL ARTICLE

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Interciencia 2013;4(3):113-120Custodio N. et al.116

ORIGINAL ARTICLE

PU�[OL�JVNUP[P]L�M\UJ[PVU�K\YPUN�[OL�SHZ[�`LHY·^OL[OLY�I`� [OL� WH[PLU[� VY� H� JHYLNP]LY�� HUK� JVUÄYTLK� I`� [OL�UL\YVWZ`JOVSVNPJHS�HZZLZZTLU[�¶^P[OV\[�KLTLU[PH�HUK�JOHUNLZ�PU�HJ[P]P[PLZ�VM�KHPS`�SPML�

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Table 1��'HPRJUDSKLF�FKDUDFWHULVWLFV�RI�SDWLHQWV�ZLWK�3DUNLQVRQ·V�GLVHDVH�DFFRUGLQJ�WR�WKH�FRJQLWLYH�LPSDLUPHQW�OHYHO��3'�&1��3'�0&,�DQG�3''��

* PD-CN vs. PDD p < 0.01 †PD-MCI vs. PDD p < 0.01 BDI-II: Beck Depression Inventory–version II. MMSE: Mini Mental State Examination. ACE: Addenbroke’s Cognitive Examination.

Results in parentheses correspond to standard deviation (SD).

AgeGender (F:M)

Education (in years)PD Duration (in years)

Hoehn-YahrBDI-IIACE

63.9 (6.3)7:15

10.9 (2.5)6.2 (3.4)1.8 (0,6)12.3 (2.7)91.9 (3.3)

70.6 (8.2)7:11

10.1 (2.4)6.4 (2.7)2.1 (0.4)11.5 (4.3)84.3 (4.1)

NSNSNSNS

< 0.01*NS

< 0.001*†

71.4 (7.1)8:15

10.3 (2.6)8.8 (5.9)2.6 (0.3)12.2 (6.7)74.9 (4.6)

PPD-CNn = 22

PD-MCIn = 18

PDDN = 23

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Interciencia 2013;4(3):113-120 Neuropsychiatric Symptoms in Parkinson’s Disease 117

ORIGINAL ARTICLE

;HISL���ZOV^Z�[OL�H]LYHNL�ZJVYL�MVY�LHJO�PUKP]PK\HS�P[LT�VM�HSS� [OL�7+�*5�WH[PLU[Z��VM� [OVZL�WH[PLU[Z�^OV�ZOV^LK� H[� SLHZ[� ZVTL�57:� �U� $� ��"� ������� HUK� [OL�WLYJLU[HNL�VM�[OVZL�̂ OV�VI[HPULK�H�ZJVYL�OPNOLY�[OHU�VY�LX\HS�[V���PU�LHJO�P[LT�VM�[OL�570����������;OL�H]LYHNL�ZJVYL�HUK�Z[HUKHYK�KL]PH[PVU��:+��VM�[OL�570�VM�HSS�WH[PLU[Z�PU�[OL�7+�*5�NYV\W�^HZ� ������ �����YLZWLJ[P]LS �̀��;OL�TVZ[� JVTTVU� Z`TW[VTZ� ^LYL� KLWYLZZPVU� �U� $� ��"��������HUK�HU_PL[`��U�$���"���������MVSSV^LK�I`�HWH[O`��U�$���"��������HUK�PYYP[HIPSP[`��U�$� "���� �����������VM�[OVZL�̂ OV�OHK�H[�SLHZ[�VUL�57:��YLWYLZLU[PUN�������V\[�VM�[OL�[V[HS�NYV\W��OHK�H[�SLHZ[�VUL�Z`TW[VT�̂ P[O�H�ZJVYL�OPNOLY� [OHU�VY�LX\HS� [V���� �(TVUN� [OLZL�WH[PLU[Z�� [OL�OPNOLZ[�ZJVYL�JVYYLZWVUKLK�[V�KLWYLZZPVU���������������HUK�KLS\ZPVUZ������������ ���MVSSV^LK�I`�HU_PL[`���������������HUK�HWH[O`���� ������� ��

0U� 7+�4*0� [OL� WLYJLU[HNL�VM� WH[PLU[Z�^OV�OHK� H[�SLHZ[�VUL�57:�^HZ����������� PUKP]PK\HSZ���^OPSL� [OH[�VM�WH[PLU[Z�YLHJOPUN�H�ZJVYL�OPNOLY�[OHU�VY�LX\HS�[V���MVY�H[�SLHZ[�VUL�P[LT�VM�[OL�570�^HZ��������;OL�H]LYHNL�ZJVYL�HUK�Z[HUKHYK�KL]PH[PVU�VM�[OL�570�MVY�HSS�[OL�7+�4*0�WH[PLU[Z�^HZ����������������YLZWLJ[P]LS �̀�;OL�TVZ[�JVTTVU� Z`TW[VTZ� ^LYL� HU_PL[`� �U� $� ��"� ��������KLWYLZZPVU��U�$���"��������HUK�HWH[O`��U�$���"���������(TVUN� WH[PLU[Z� ^OV� OHK� H[� SLHZ[� VUL� 57:� HUK� VUL�Z`TW[VT�ZJVYLK�OPNOLY�[OHU�VY�LX\HS�[V����[OL�OPNOLZ[�ZJVYLZ�^LYL� VI[HPULK� PU� [OL� P[LTZ�VM� HU_PL[`� ��� �����������HWH[O`����������������PYYP[HIPSP[`���������������HUK�ZSLLW�KPZVYKLYZ���������������

4VZ[� WH[PLU[Z� VM� [OL� 7++� NYV\W� �U� $� ��"� ������OHK�H[�SLHZ[�VUL�57:��^OPSL�[OL�WLYJLU[HNL�VM�WH[PLU[Z�

Table 2��$YHUDJH�VFRUH�RI� WKH� LWHPV� LQ� WKH�1HXURSV\FKLDWULF� ,QYHQWRU\� �13,�� LQ�DOO� SDWLHQWV�ZLWK�3DUNLQVRQ·V�GLVHDVH��DFFRUGLQJ� WR� FRJQLWLYH�impairment level and patients showing symptoms.

Item NPI

Delusions

Hallucinations

Agitation / aggressiveness

Depression / dysphoria

Anxiety

Euphoria

Apathy

Disinhibition

Irritability

Aberrant motor behavior

Sleep disorders

Appetite problems

NPI TOTAL

PD-CN (n = 22)

AllPoints in

NPI mean (SD)0.43

(1.38)0.48

(1.53)0.58

(1.52)2.37

(2.65)2.23

(2.49)0.24

(1.11)1.41

(2.10)0.25

(0.93)1.12

(1.79)0.28

(1.27)1.34

(0.98)0.47

(0.36)9.64

(9.36)

Pointsin NPImean(SD)3.36

(2.79)2.90

(2.38)2.54 (227)3.46

(2.63)3.25

(2.56)2.25

(2.38)2.91

(2.49)2.12

(1.98)2,42

(1.12)2.78

(2.48)3.16

(2.45)2.56

(1.89)11.24

(10.43)

PercentageZLWK�13,���

N (% total)

2 (9.1)

2(9.1)

1 (4.5)

7(31.8)

6(27.3)

1(4.5)

4(18.2)

2(9.1)

4(18.2)

1(4.5)

2(9.1)

2(9.1)14

(63.6)

Patients con NPS AllPoints in

NPI mean (SD)1.25

(1.27)0.87

(1.45)0.67

(1.58)2.59

(2.08)2.81

(2.12)0.28

(1.23)1.98

(1.89)0.57

(1.12)1.25

(1.68)0.75

(1.43)1.45

(1.16)1.21

(0.76)12.13

(10.76)

Pointsin NPImean(SD)2.45

(2.13)2.06

(1.98)2.24

(2.18)2.17

(2.34)3.96

(2.71)2.23

(2.16)3.56

(2.54)2.28

(1.76)3.81

(2.37)2.16

(1.76)3.16

(1.76)2.68

(1.94)14.35

(11.56)

PercentageZLWK�13,���

N (% total)

4 (22.2)

3(16.6)

4(22.2)

3(16.6)

6(33.3)

3(16.6)

7(38.9)

3(16.6)

5(27.8)

3(16.6)

6(33.3)

4(22.2)

13(72.2)

Patients con NPS AllPoints in

NPI mean (SD)1.98

(3.56)1,99

(3.12)1.31

(2.23)1.56

(2.56)1.83

(2.71)0.18

(0.68)2.58

(3.59)0.46

(1.23)1.42

(2.47)1.32

(2.48)2.56

(3.67)1.97

(3.84)19.35

(20.43)

Pointsin NPImean(SD)4.96

(3.74)3.93

(3.42)2.98

(2.48)3.16

(2.88)3.17

(2.79)1.51(1.1)4.77

(3.49)2.46(2.1)3.53

(2.96)3.56(3.8)4.87

(3.71)4.14

(3.88)21.42

(20.54)

PercentageZLWK�13,���

N (% total)

6(26.1)

5(21.7)

3(13)

4(17.4)

5(21.7)

1(4.3)

8(34.8)

1(4.3)

3(13)

4(17.4)

8(34.8)

6(26.1)

17(73.9)

Pacientes con SNP

PD-MCI (n = 18) PDD (n = 23)

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Interciencia 2013;4(3):113-120Custodio N. et al.118

ORIGINAL ARTICLE

Table 3. Percentage of patients with NPS out of PDD patients.

DelusionsHallucinations

Agitation / aggressivenessDepression / dysphoria

AnxietyEuphoriaApathy

DisinhibitionIrritability

Aberrant motor behaviorSleep disorders

Appetite problems

Neuropsychiatric Symptoms

5810414311498128

N

21.734.743.517.460.913.047.817.439.134.752.234.7

%

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+0:*<::065

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0U� JVUJS\ZPVU�� [OPZ� Z[\K`� YLWYVK\JLZ� HUK� L_[LUKZ�WYL]PV\Z�ÄUKPUNZ�VM�OPNO�WYL]HSLUJL�VM�57:�HTVUN�7+�WH[PLU[Z��HUK�KYH^Z�H[[LU[PVU�[V�HUHS`aL�[OL�M\SS�ZWLJ[Y\T�VM�7+�ILOH]PVYHS�JOHYHJ[LYPZ[PJZ�MYVT�LHYS`�Z[HNLZ��;OL�Z`Z[LTH[PJ�YLJVNUP[PVU�VM� [OL�WYLZLUJL�HUK�ZL]LYP[`�VM�JVTVYIPK�UL\YVWZ`JOPH[YPJ�JVUKP[PVUZ�PU�7+�JHU�OLSW�[OL� ZWLJPHSPZ[� IV[O� PU� [OL� JSPUPJHS�THUHNLTLU[� VM� [OL�KPZLHZL�HUK�[V�PTWYV]L�[OL�X\HSP[`�VM�SPML�VM�WH[PLU[Z�HUK�[OLPY�JHYLNP]LYZ�

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ORIGINAL ARTICLE

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Interciencia 2013;4(3):113-120Custodio N. et al.120

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