Juan Carlos Torres Sánchez #804-11-9230 BIOL 3095

Ranganathan S, Williams E, Ganchev P, Gopalakrishnan V, Lacomis D, Urbinelli à L,

Newhall K, Cudkowicz ME, Brown Jr. RH and Bowser R. 2005. Proteomic profiling

of cerebrospinal fluid identifies biomarkers for amyotrophic lateral sclerosis. Journal

of Neurochemestry. 95:1461–1471

This review is about Amyotrophic Lateral Sclerosis (ALS) and profiling biomarkers

for this disease. ALS is a neurodegenerative disease that causes damage to motor

neurons located in the cerebral cortex, brainstem and spinal cord. To help detect

specific biomarkers in this research,they used cerebrospinal fluid (CSF) from ALS

patients and from the control subjects using surface-enhanced laser desorption/

ionization-time of flight mass spectrometry (SELDI-TOF-MS). This technique has

better precision in identifying biomarkers. Three biomarkers were found in the results,

transthyretin, cystatin C, and carboxy-terminal fragment of neuroendocrine protein

7B2. Two of these biomarkers were validated, showing a section of CSF biomarkers

of ALS patients. This study is very useful because it displays the correlation of how

important it is to find biomarkers for ALS patients and how cystain C can be a great

biomarker for that disease.