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BIOLOGICAL OXIDATION
Dr Vijay MarakalaAssistant professor
BiochemistrySIMS&RC
BIOLOGICAL OXIDATION
Oxidation Biological oxidation
Phosphorylation
Oxidative phosphorylatio
n
Biological oxidative
phosphorylation
Requirements for biological
oxidation
OXIDATION OF FOOD STUFFS IN THREE STAGES
Primary metabolism Secondary metabolism Tertiary metabolism
BIOLOGICAL OXIDATION
OXIDATION• Removal of electrons
REDUCTION• Gain of electrons
OIL
REG
BIOLOGICAL OXIDATION & PHOSPHORYLATION
Biological oxidationOxidation which occurs in living system
Phosphorylation The formation of ATP from
ADP and Pi
BIOLOGICAL OXIDATIVE PHOSPHORYLATION
Biol
ogic
al o
xida
tive
phos
phor
ylat
ionBiol
ogic
al
oxid
atio
n
Phos
phor
ylat
ion
BIOLOGICAL OXIDATION
REQUI
REM
ENTS
ENZY
MES
COEN
ZYM
ES
ELEC
TRON
CARR
IERS
BIOLOGICAL OXIDATION - REQUIREMENTS
ENZYMES
Oxidases
Dehydrogenases
Hydroperoxidases
Oxygenases
COENZYMES
NAD+
NADP+
FMN
FAD
BIOLOGICAL OXIDATION - REQUIREMENTS
CYTO
CHRO
MES
Cyt a
Cyt b
Cyt c
ELECTRON CARRIERS
OXIDASES
Cytochrome oxidase
L- amino acid oxidase
Xanthine oxidase
DEHYDROGENASES
Require specific coenzymes
Nicotinamide coenzymes• NAD+or NADP+
Flavin coenzymes• FMN or FAD
Coenzyme
Dehydrogenase specific for A
Dehydrogenase specific for B
NAD+ LINKED COENZYMES
Involved in
Glycolysis TCAETC
NAD+ NADH+H+
FLAVIN- COENZYME LINKED DEHYDROGENASE
2H
FMN FMNH2
HYDRO PEROXIDASES
CATALASESPEROXIDASES
DIOXYGENASESMONO OXYGENASES
OXYGENASES
ENZYMES N OF BIOLOGICAL OXIDATION
Use oxygen as an electron acceptorOxidases
Can’t use O2 as an electron acceptorDehydrogenases
Use H2O2 as a substrate
Hydroperoxidases
Catalyse the direct transfer of O2 into the substrate Oxygenases
ELECTRON CARRIERS
Iron
conta
inin
g
elect
ron
transfe
rring
prote
ins
CYTOCHROMES
Next class ETCPlease read and come