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Thanos KosmidisCo-founder & CEO
Personalized services for cancer patients
14m new cancer
diagnoses annually
1 in 4 patients report
“feeling isolated”
4
Average time with
doctor: <20 minutes
6
14165 oncology clinical trials
open for patient participation
7
50+ oncologists
available to
answer questions
1500+ curated articles
200+ original articles
20+ videos & webinars
9
Anonymous patient community
© 2017 Care Across
What Patients say
"Thank you so much for your help and advice.
It helps to not feel alone in all of this.”
“I had some high-level knowledge.
Your site informed me with adequate details.”
“Thank you so so much you have been amazing support
and made me realize I'm not alone!!”
“Thanks for all that you do.
It is because of people like you that those affected by cancer
are able to find a way to smile through treatment."
"That's my reading material sorted! You are wonderful!!"
"Thank you for your help it really is appreciated"
"Thank you very much for that. Thank you again for your attention."
"Just like to say thank you for your advice."
"Thank you so so much for investigating for me, you are so helpful."
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© 2017 Care Across
Recognition & Revenue
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• Ongoing
partnerships on a
global scale
• Contracts with
pharmaceutical
and diagnostics
companies
© 2017 Care Across
Patients’ top Nutrition concerns
Do not know what to eat36%
Need to know what to avoid
eating28%
I am gaining weight
15%
I have no appetite9%
I am overeating7%
I am losing weight5%
Source: CareAcross Research
© 2017 Care Across
Problems extend beyond Nutrition
• 52%: clinicians inadequately informed on
nutrition
• 74%: loss of muscle mass causes side
effects
• 80%: have nutrition problems
• 83%: experience appetite problems
• 90%: nutrition issues affect wellbeing
Source: European Cancer Patient Coalition survey & report, 201513
© 2017 Care Across
Nutrition, Exercise & Wellbeing service
Algorithm identifying specific coaching tips per individual, from• Diagnoses, treatments
• Co-morbidities
• Weekly food intake
• Exercise routines
• Side-effects
Mechanism to derive each patient’s overall Score & area-specific scores
Triggers for warning signs for visiting the doctor/hospital
Patient
Patient data
(anonymous)
Diagnoses TreatmentsCo-
morbidities
Nutrition Exercise Wellbeing
Current
status
Recent
events
Additional
info
Research
database
Input Guidance
Communication &
Follow-up module
Rules
Scoring
Algorithms
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© 2017 Care Across
Artificial Neural Network
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In
In
In
In
Input Hidden layers (intermediate & special cases)
Out
Out
Out
Out
Output
© 2017 Care Across
…after loading 300+ publications
16
In
In
In
In
Input Hidden layers (intermediate & special cases)
Out
Out
Out
Out
Output
© 2017 Care Across
Personalization in breast cancer:
1.7m diagnoses annually
• Diagnoses: 30+
– Stages and Metastases: 20+
• Treatments: 50+
– Lines of treatments: ~3
• Co-morbidities: 15+
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In theory:
1.35 million
combinations
In medical practice:
~20K combinations
Screenshots from Pilot
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© 2017 Care Across
Diagnoses input
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© 2017 Care Across
Health Profile input
20
© 2017 Care Across
Score History
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Business Model
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© 2017 Care Across
Global oncology drugs industry
to reach $147B in 2018
© 2017 Care Across
Services to Pharmaceutical &
Biotech companiesOncology Clinical
Trials
• 87% delay due to recruitment2
• Revenue loss: up to $21M/day2
• 14.1K+ trials recruiting globally3
Patient Support Programs
• Cancer becoming a “chronic condition”
• 32m+ people affected globally; ~10m in Europe4
• Patient Support improves quality of life & reduces healthcare costs
Real-World Evidence
• Healthcare Analytics industry worth $20.8B in 20205
• Oncology: top therapeutic area
• #1 in R&D focus6
• Long-term treatments & follow-ups
• Personalized
Medicine trends
Sources: 1: IMS Health Institute, Global Oncology Trend report, June 2016
2: Beasely, “Recruiting” (2008); loss projected based on global sales of top oncology drugs
3: ClinicalTrials.gov
4: GLOBOCAN 2012 (IARC) Section of Cancer Surveillance
5: IQ4I Research & Consultancy, 2014
6: “Drug Trend Report”, Medco, 201024
Team
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© 2017 Care Across
Multi-disciplinary founding team
Thanos Kosmidis
Chief Executive
Officer
• 15-year experience in technology & business (UK, USA, Greece)
• Verizon, WIND, Deutsche Telekom
•Helped grow a team of 5 to 180, with budget responsibility
• Launched telecom services used by millions of customers
• Imperial College, Carnegie Mellon, MIT
Paris Kosmidis
Chief Medical
Officer
• 40-year clinical experience in medical oncology (USA, Greece)
• Past President of European Medical Oncologists
• Led 10,000+ oncologists and multiple boards & committees
• Author of 100s of publications and books
• Awarded by Academy of Athens twice
Takis Vidalis
Legal Counsel
• Legal Expert at European Commission & Research Council
• Leading international workgroups on clinical trials
• Legal Advisor at National Bioethics Commission (Greece)
© 2017 Care Across
…supported by top
International Scientific Committee
30 oncologists from 20 countries, including:
• 7 current or past
Presidents of European
or American Oncology
Societies
• 6 founders of Oncology
Societies in their
country or continent
• 12 Oncology Professors at:– Harvard
– Oxford
– Hong Kong
– Sydney
– Texas MD Anderson
– Paris
– Tel Aviv
– Karolinska
– Zurich
– Vienna
– Halle/Germany
– Napoli 27
Digital Health:
Challenging
the status quo
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© 2017 Care Across
When your users are Patients or
Caregivers…
• Respect
• Understand
• Empathize
• Serve
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© 2017 Care Across
When Patients trust you with
their data…
• Data Protection
• Legal framework
• Regulatory structures
• Ethics
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© 2017 Care Across
When your clients are
multinationals…
• Understand their position & processes
• Build relationships early
• “Educate” them and learn from them
• Listen to their needs
• Persist
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The Future
32
© 2017 Care Across
CareAcross in the future
33
PatientsCaregivers
Prevention
Mobile Apps
Wearables
Internet of Things
Tools for Doctors
Bots
© 2017 Care Across
Tech stack
• Heroku hosted Platform-As-A-Service
• Dynamic Programming module
• MVC based web application
• Ruby on Rails
• Resque
• PostgreSQL
• NoSQL
• Big Data-oriented from ground up
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