Circadian rhythms

&

Human health

Presented by Dr. Sudhakar KokateDirector PPRC, India

Circadian rhythms .…

Also known as the “Body clock”

Physical, mental and behavioural changes that

follow a roughly 24 hrs. cycle responding to light

and darkness in the organism

Found in living things, plants, animals and even

among tiny microbesPPRC/INDIA 01

Circadian rhythms .…

PPRC/INDIA 02

Circadian rhythms ….

Related to biological cycle

Study of Circadian rhythms and health is known

as “Chronobiology”

Biological cycle controls Circadian rhythms –

governing of interacting molecules in cells

throughout the bodyPPRC/INDIA 03

Master clock ….

Master clock: Brain

A group of nerve cells ‘Suprachiasmatic nucleus’

(SCN) containing 20,000 nerve cells are located

in hypothalamus

Location: above optic nerves from eyes cross

PPRC/INDIA 04

Brain

PPRC/INDIA 05

Suprachiasmatic nucleus

PPRC/INDIA 06

About CR ….

Circadian rhythms influence sleep wake cycles,

hormone release and other bodily functions

CR – linked to sleep disorders e.g. Insomnia,

Obesity, Diabetes, Depression, Bipolar disorders

and Seasonal Affective Disorder (SAD)

PPRC/INDIA 07

Insomnia

PPRC/INDIA 08

Obesity

PPRC/INDIA 09

Diabetes

PPRC/INDIA 10

Depression

PPRC/INDIA 11

Bipolar disorders

PPRC/INDIA 12

Seasonal Affective Disorder (SAD)

PPRC/INDIA 13

About CR ….

CR tells our body when to sleep and regulate

many other physiological processes

This internal body clock is affected by

environmental cues like sunlight and

temperature

When CR is disrupted, sleeping & eating

patterns can run amokPPRC/INDIA 14

Physiological disruption leads to ….

PPRC/INDIA 15

Research ….

A growing body of research is examining the

adverse health effects like increasing cardio-

vascular events, observing neurological problems

like depression and bipolar disorders.

It also affects immune and metabolic systems

PPRC/INDIA 16

Immune system

PPRC/INDIA 17

Metabolic system

PPRC/INDIA 18

Research ….

Scientists are looking into:

1. How brain-neuro system works in disorder?

2. What are effective remedies without side effects

with minimum duration of time span?

3. Behaviour of Human being in disrupted CR

positionPPRC/INDIA 19

Research ….

4. Treatment of sleep disorders, Jet lag and other

health related issues

5. Do Ayurvedic plants control Circadian rhythms

in plants, animals and microbes? If so how and

at what level of output?

PPRC/INDIA 20

Research ….

6. Are there any natural control for strengthening

nerves and muscle? If so how and what

mechanism does it possess?

PPRC/INDIA 21

Remedies ….

Change or modify lifestyle

Ideal diet plan – implementation

Yoga, exercises and meditation

Use of herbal technology

Well disciplinary actions in exact time

Strengthen and calm – nerves and musclesPPRC/INDIA 22

Yoga

PPRC/INDIA 23

Exercise

PPRC/INDIA 24

Meditation

PPRC/INDIA 25

Cryobiology

Study of cell preservation technology with low

temperature

Applied science

Rule: Every 10°C reduction in temperature

= 50 % decrease in oxygen consumption

PPRC/INDIA 26

Cryobiology

Temperature ranges 32 to 37°C

and -80 to -196°C

Many Journals, Societies study Cryobiology

PPRC/INDIA 27

Neurochemicals ….

Organic molecules participating in Neural activity

Neuropeptide: Oxytocin signifies maternal

behaviour, stress wound healing

Glutamate

GABA: Inhibits neurotransmission

PPRC/INDIA 28

Neurochemicals

PPRC/INDIA 29

Neuropeptide

PPRC/INDIA 30

Oxytocin

PPRC/INDIA 31

Glutamate

PPRC/INDIA 32

GABA

PPRC/INDIA 33

Neurochemicals ….

Organic molecules participating in Neural activity

Dopamine: Function of the limbic system,

emotional function and control

Serotonin: Mood, sleep and alertness, sensation

of pleasure

PPRC/INDIA 34

Dopamine

PPRC/INDIA 35

Serotonin

PPRC/INDIA 36

Neurochemicals ….

Organic molecules participating in Neural activity

Acetylcholine: Memory

Nitric oxide

Endocannabinoids: Eicosanoids

PPRC/INDIA 37

Acetylcholine

PPRC/INDIA 38

Nitric oxide

PPRC/INDIA 39

Endocannabinoids

PPRC/INDIA 40

Foods for healthy nerves ….

₪ Milk

₪ Yogurt

₪ Honey

₪ Apple

₪ Mangoes

PPRC/INDIA 41

₪ Potatoes

₪ Bananas

₪ Herbal tea

₪ Whole grain

₪ Sweet potatoes

Foods for healthy nerves ….

PPRC/INDIA 42

Foods for healthy nerves ….

₪ Pineapples

₪ Beet salad

₪ Grape fruits

₪ Oranges

₪ Almonds

PPRC/INDIA 43

₪ Green salad

₪ Dates

₪ Cashew nuts

₪ Coconut water

PPRC/INDIA 44

₪ Tulsi

₪ Sunflower

₪ Papaya

₪ Peppermint

PPRC/INDIA 45

₪ Avocado

₪ Cabbage

₪ Cauliflower

₪ Asparagus

Tulsi (Ocimum sanctum)

PPRC/INDIA 46

Sunflower

PPRC/INDIA 47

Papaya

PPRC/INDIA 48

Peppermint

PPRC/INDIA 49

Avocado

PPRC/INDIA 50

Cabbage

PPRC/INDIA 51

Cauliflower

PPRC/INDIA 52

Asparagus

PPRC/INDIA 53

₪ Alfalfa

₪ Parsley

₪ Garlic

₪ Beet

PPRC/INDIA 54

₪ Kale

₪ Hemp

₪ Fenugreek

₪ Lime

Alfalfa

PPRC/INDIA 55

Parsley

PPRC/INDIA 56

Garlic

PPRC/INDIA 57

Beet

PPRC/INDIA 58

Kale

PPRC/INDIA 59

Hemp

PPRC/INDIA 60

Fenugreek

PPRC/INDIA 61

Lime

PPRC/INDIA 62

Thank You !!

“BE WITH US”