Clinical uses of systemic corticosteroids

Presented by :

Muhammad Aiman Shukrie bin Shamsul Ismai

Brief properties and mechanism of action of corticosteroids

• Corticosteroids are synthetic analogues of the natural steroid hormones produced by the adrenal cortex. Like the natural hormones, these synthetic compounds have glucocorticoid (GC) and/or mineralocorticoid properties. Mineralocorticoids affect ion transport in the epithelial cells of the renal tubules and are primarily involved in the regulation of electrolyte and water balance. GCs, on the other hand, are predominantly involved in carbohydrate, fat and protein metabolism, and have anti-inflammatory, immunosuppresive, anti-proliferate, and vasoconstrictive effects

Field of medicine

Allergy and respirology Dermatology Endocrinology

Gastroenterology Hematology Rheumatology

Ophthamology Other

Allergy and respirology

• Disorders:• Moderate to severe athma exacerbations• Acute exacerbations of chronic obstructive pulmonary disease• Allergic rhinitis• Atopic dermatitis• Urticaria/angioedema• Anaphylaxis• Food and drug allergies• Nasal polyps• Hypersensivity pneumonitis• Sarcosoids• Acute and chronic eosinophils pneumonia• Interstitial lung disease

Dermatology

• Disorders:• Pemphigus vulgaris• Acute, severe contact dermatitis

Endocrinology

• Disorders• Adrenal insufficiency• Congenital adrenal hyperplasia

Gastroenterology

• Disorders• Ulcerative colitis• Crohn’s disease• Autoimmune hepatitis

Hematology

• Disorders• Lyphoma/leukemia• Hemolytic anemia• Idiopathic thrombocytopenic purpura

Rheumatology/immunology

• Disorders• Rheumatoid arthritis• Systemic lupus erythematosus• Polymyalgia rheumatica• Polymyositis/dermatomyositis• Polyarteritis• Vasculitis

Ophthalmology

• Disorders• Uveitis• Keratoconjuctivitis

Other

• Disorders• Multiple sclerosis• Organ transplantation• Nephrotic syndrome• Chronic active hepatitis• Cerebral edema

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