Cloud pharmaceuticals (2)

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Cavendish Global Health Impact ForumOctober 25-28, 2015• Ed Addison,• Chairman, Co-Founder and CEO


PRESENTATION TITLE

Cavendish Global Health Impact ForumOctober 25-28, 2015• Ed Addison,

• Chairman, Co-Founder and CEO

About Our Company

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About Our Company

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www.cloudpharmaceuticals.com 01



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One Column TextPut your great subtitle here


Contains every small molecule to increase the wellness of people around the world, to prevent people from dying, to relieve their pain and suffering

The trick is to find the right ones

Virtual Molecular SpacePut your great subtitle here


Cloud Pharmaceuticals

Atomwise

PharmacopiaNumerate

E-Therapeutics

Verseon

Schrodinger

AC

CU

RA

CY

D I V E R S I T Y

Competitive Landscape

Competitive AdvantagesPut your great subtitle here

1Use of artificial intelligence searches novel molecular space to identify the strongest matches to protein targets, resulting in original IP and enormous diversity

Binding affinity of molecules to targets achieves >80% correlation using quantum chemistry, making our process very accurate

Biophysical models of chemical properties enables selection of very good drug candidates

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Collaboration developing 12 drugs, validation data

Grant for development of discovery methods and select drugs

Muscle growth and inflammation research

Autism and cancer research Malaria collaboration

Collaboration developing 7 drug programs

Valuable RelationshipsPut your great subtitle here


Pancreatic Cancer

People diagnosed50,000 Of all cancers in the US3%

Of all cancer deaths in the US7%Will die from pancreatic cancer40,560

Key statistics for 2015 from the American Cancer Society:

Quantum Molecular Design Process

How We Do ItPut your great subtitle here

01Design compounds that inhibit the activity of protein targets, which are produced by the genes responsible for certain pathologies

Combine high-performance cloud computing, quantum mechanics/molecular mechanics, and molecular property simulation

Fundamentally transform and improve the design of new medicines

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Questions?Ed Addison, CEO

Cloud Pharmaceuticals Inc.6 Davis Drive

Research Triangle Park, NC 27709(910) 398-1200

[email protected]

mailto:[email protected]

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DRUG DISCOVERY

10,000COMPOUNDS

PRE-CLINICAL

250

CLINICAL TRIALS

1DRUG

Traditional discovery has

Low probability of success

High-throughput screening is

Very inefficient

Timelines and costs of past development efforts are

Prohibitive

Previous in silico methods areUnreliable

The OpportunityPut your great subtitle here

ACHIEVES FDA APPROVAL


• Why?

• Moore's Law• Accessibility of cloud-based

super computing• Artificial intelligence

• How?• Store 3D model of every

human protein in the druggable genome

• Analyze a proposed drug for toxicity prior to clinical trial

Emerging life sciences data center

The Time is Now for In SilicoPut your great subtitle here


Appendix1 Cloud Pharmaceuticals

Investor Overview

Fall 20152

AI technology identifies novel targets by souring published

research enabling basket trials

Designs drug leads for those targets and filters for drug properties such

as blood–brain barrier

Finding a Cure


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02 03Targets pancreatic cancer using real genomics data

Uses genome data and DNA analysis

to discover novel drug targets

Designing drug leads for those targets

Finding a CurePut your great subtitle here


Health & Medicine

Cloud pharmaceuticals (2)