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&Luis Téllez Universidad de Yale
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¿Cómo elegimos lo que comemos? El sistema dopaminérgico como un
sensor calórico.
Congreso Internacional de Nutrición Dr. José María Bengoa Caracas, Venezuela
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Tellez L A et al. J Physiol 2013
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El Sistema Dopaminérgico Nigrostriatal…
• Juega un papel crítico en la conducta (e.g. atención, motivación, recompensa, la conducta dirigida por objetivos, y la adquisición de “hábitos” , incluyendo la auto-administración de drogas);
• Los ratones deficientes en DA mueren de hambre, un efecto que puede ser revertido mediante la restauración farmacológica de DA en el estriado dorsal;
• Los niveles extracelulares de DA se incrementan durante la ingestión de alimentos.
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Tellez L A et al. J Physiol 2013
¿Es posible regular la ingesta calórica en ausencia de esFmulación
gustaFva?
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Tellez LA et al. Biological Psychiatry 2013
Los niveles extracelulares de dopamina en el estriado reflejan la ingesta calórica, incluso en la ausencia de señales gusta=vas.
En ausencia de señales gustaFvas, bloquear el receptor de dopamina interrumpe la detección de calorías.
Ferreira J G et al. J Physiol 2012 ©2012 by The Physiological Society
¿Cómo afecta el estado metabólico a este sensor
calórico?
Se ha propuesto que la disminución en la función dopaminérgica conlleva a la sobrealimentación como un mecanismo compensatorio.
La respuesta dopaminérgica se encuentra alterada en organismos obesos.
(Wang et al, 2001)
(Johnson & Kenny, 2010)
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Daniele Piomelli
Trends in Endocrinology & Metabolism Volume 24, Issue 7 2013 332 -‐ 341
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¿Cuáles son las consecuencias conductuales derivadas del
incremento en los niveles de DA inducidos por la OEA?
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Gracias Fundación Bengoa para la Alimentación y Nutrición Yale University Ivan E. de Araujo Sara Medina Jozelia Ferreira Wenfei Han Xueying Ren Dana Small Tukiet Lam Albert Einstein College of Medicine Gary J Schwartz
Funding National Institute on Deafness and Other Communication Disorders (NIDCD) National Institute on Diabetes, Digestion and Kidney (NIDDK) Ajinomoto, Inc.
(J1*7(I think this is the beginning of a beautiful friendship!
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Dopaminergic effects of OEA are mediated by the nuclear receptor PPAR-‐α and by the vagus
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