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CROMOLYN SODIUM

Amitsinh ViholExam No-43

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CROMOLYN SODIUM

According to WHO,• Worldwide 235 millions patient of asthma• In India, 15-20 million patient (15-20% are 5-11 year old children)• 1,80,000 death every year in the world.

• First line agent into mild to moderate asthma• Safer treatment, less adverse effect.

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CROMOLYN SODIUMPHARMACOLOGY• Pharmacologic class: Chromone derivative• Therapeutic class: Mast cell stabilizer, antiasthmatic,

ophthalmic decongestant.• Pregnancy risk category B• Mechanism of Action-Inhibits release of histamine and

reacting substances of anaphylaxis from mast cells, stabilizing the cell membrane and reducing the allergic response and inflammatory reaction.

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CROMOLYN SODIUMAdverse reactions• CNS: headache, dizziness• Respiratory: wheezing, cough, nasal irritation, stuffy nose,

sneezing, sore throat• GI: nausea, diarrhea, stomachache• Urinay: difficult or painful urination• Skin: rash• Other: altered taste, substernal burning, allergic

reactions.

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CROMOLYN SODIUMINDICATION-• Prophylactic in the management of patients with bronchial

asthma.• Prevention of exercise-induced bronchospasm; • Adjunct in prevention of allergic disorders including rhinitis

CONTRAINDICATIONS-• Contraindicated in those patients who have shown

hypersensitivity to cromolyn sodium.

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CROMOLYN SODIUMDOSAGE-Usual Adult Dose for Asthma -- Maintenance:• Nebulization solution: 20 mg 4 times a day at regular

intervals.• Metered dose inhaler: 2 puffs 4 times a day at regular

intervals. Usual Pediatric Dose for Asthma -- Maintenance:• Nebulization solution:

> 2 years: 20 mg 4 times a day at regular intervals.• Metered dose inhaler:

> 5 years: 2 puffs 4 times a day at regular intervals.

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CROMOLYN SODIUM

COMPETITOR- • Fintal(Abbot)-(94RS/5 vial of each 2ml)

• Nalcrom (Sanofi-Aventis)-($10/20ml)

• Nasalcrom(Prestige Brands)-($9/13ml)

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CROMOLYN SODIUM

STORAGE & LABELLING-• Store at 20°-25°C (68°-77°F).• Do not use if solution is discolored or contains a precipitate.• Retain in foil pouch until time of use.• PROTECT FROM LIGHT.• KEEP THIS AND ALL MEDICATIONS OUT OF THE REACH OF

CHILDREN.

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CROMOLYN SODIUM

PACKAGING & AVAILABLE DOSAGE FORM-• Packed in vial which is made from a low density polyethylene

(LDPE) resin.• Cromolyn Sodium Inhalation Solution Unit-Dose 2 mL Vial is

supplied as a colorless to pale yellow solution containing 20 mg cromolyn sodium, USP, in water for injection, USP, with 5 vials per foil pouch in cartons as listed below.

• 60 vials per carton. • 120 vials per carton.

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CROMOLYN SODIUM

PRICING• 90Rs/5 vial Each contain 2ml

• 999Rs/Cartoon of 60 Vials

• 1999Rs/Cartoon of 120 vials

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CROMOLYN SODIUM

• REFRENCE-• Rang & Dale’s Pharmacology by H.P.Rang, M.M.Dale, et all.,6th

edition, Page no-364-365• http://www.nlm.nih.gov/medlineplus/druginfo/meds/

a601042.html• http://www.drugs.com/mtm/cromolyn-sodium-

inhalation.html• http://dailymed.nlm.nih.gov/dailymed/lookup.cfm?

setid=AEC8F12A-B778-4AB5-A932-FDFB620FD50B#section-10

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