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Drugs Affecting Urinary System
Diuretics
BYDINA ABDEL-AZIM GHAZY GHORABA
LECTURER OF MEDICAL SCIENCE
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Outlines: 1 -Diuretics
A-Loop Diuretics → Furesmide (Lasix®)
B- Thiazides → Chlorothiazide (Diuril®)
C- Potassium Sparing Diuretics → Spironolactone (Aldactone®)
D- Osmotic Diuretics → Mannitol (Osmitrol®)C- Carbonic Anhydrase Inhibitors → Acetazolamide (Diamox®)
2 -Urinary antiseptics -Ciprofluxacine HCl (Cipro®)
-Nitrofurantoin (Macrodantin®)
3 -Urinary analgesicPhenazopyredine
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References:• Catherine Paradiso.1998 , Pharmacology. Lippincott’s.
USA.• Bruce D. Clayton., Yvonne N. Stock.1997, Basic
pharmacology for nurses. 11th Ed, Mosby.USA. • Ben Greenstein., 2004 , Trounce’s Clinical
Pharmacology for Nurses. 17th Ed, Churchill Livingstone.USA.
• Brunner & Suddarth., 2004 , Medical-Surgical Nursing. 10th Ed, Lippincott’s. USA.
• http://en.wikipedia.org/wiki/Adenosine• Amy M. Karch., 2003 , Nursing Drug Guide.
Lippincott’s. USA.
Cortex
Medulla
ThiazidesInhibit active exchange of Cl-Na in the cortical diluting segment of the ascending loop of Henle
K-sparingInhibit reabsorption of Na in the distal convoluted and collecting tubuleLoop diuretics Inhibit exchange of Cl-Na-K in the thick segment of the ascending loop of Henle
Loop of HenleCollecting tubule
Diuretics
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Study Questions
1. Which of the following Diuretics is the first line used to Glaucoma?
a. Lasix® b. Aldactone ®c. Diuril®d. Diamox®
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2. Which of the following Diuretics is the first line used to Hypertension with Hyperkalemia ?
a. Lasix® b. Osmitrol®c. Aldactone®d. Diamox®
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3. Which of the following Diuretics is the first line used in cases of Hyperaldosteronism ?
a. Lasix® b. Aldactone ®c. Diuril®d. Diamox®
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4. Which of the following Diuretics is the first line used to Hypertention?
a. Lasix® b. Aldactone®c. Diuril®d. Diamox®
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5. Which of the following Diuretics is the first line used in cases of edema ?
a. Lasix® b. Aldactone®c. Diuril®d. Diamox®
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6. Which of the following Diuretics is the Second line used to Hypertension?
a. Lasix® b. Aldactone®c. Diuril®d. Diamox®
Abdulqadir Nashwan 11
2. Complete the following Table with an appropriate diuretics below
-Loop Diuretic -Osmotic Diuretics
-Potassium Sparing diuretics -Thiazides -Carbonic Anhydrase Inhibitors
Diuretic Site of Action
Loop of Henle
Distal Convoluted Tubule
Collecting Tubule
Proximal Convoluted tubule
Entire Tubule
