Generic Sinemet Tablets
Generic Sinemet (Syndopa Tablets) is a combination of Carbidopa
and Levodopa used for the treatment of Parkinson's disease and
syndrome.
Chemical Structure - Carbidopa
Chemical Structure - Levodopa
Generic Sinemet is indicated in the treatment of the symptoms of
idiopathic Parkinson's disease (paralysis agitans),
post-encephalitic parkinsonism, and symptomatic parkinsonism which
may follow injury to the nervous system by carbon monoxide
intoxication and/or manganese intoxication. Generic Sinemet is
indicated in these conditions to permit the administration of lower
doses of levodopa with reduced nausea and vomiting, with more rapid
dosage titration, with a somewhat smoother response, and with
supplemental pyridoxine (vitamin B6).
Indications
The active pharmaceutical ingredients contained in Generic
Sinemet Tablets (Syndopa Tablets) are Carbidopa and Levodopa
Active Ingredient
The Generic Sinemet (Syndopa) is supplied as tablets in four
strengths:Syndopa 110 mg (Levodopa 100mg & Carbidopa 10mg) or
Generic Sinemet 10-100Syndopa 125 mg (Levodopa 100mg &
Carbidopa 25mg) or Generic Sinemet 25-100Syndopa 250 mg (Levodopa
200mg & Carbidopa 50mg) or Generic Sinemet 50-250Syndopa 275 mg
(Levodopa 250mg & Carbidopa 25mg) or Generic Sinemet 25-250
Strengths
The recommended dosage of Generic Sinemet (Syndopa Tablets) is
given below:Syndopa 125 mg (Levodopa 100mg & Carbidopa 25mg) :
The recommended starting dosage is one tablet of Generic Sinemet
25-100 (Levodopa 100mg & Carbidopa 25mg) three times a day.
This dosage schedule provides 75 mg of carbidopa per day. Dosage
may be increased by one tablet every day or every other day, as
necessary, until a dosage of eight tablets of Generic Sinemet
25-100 a day is reached.
Recommended Dosage
The recommended dosage of Generic Sinemet (Syndopa Tablets) is
given below: Syndopa 110 mg (Levodopa 100mg & Carbidopa 10mg):
The recommended starting dosage of Generic Sinemet 10-100 (Levodopa
100mg & Carbidopa 10mg) is one tablet three or four times a
day. However, this will not provide an adequate amount of carbidopa
for many patients. Dosage may be increased by one tablet every day
or every other day until a total of eight tablets (2 tablets four
times a day) is reached.
Recommended Dosage
Contraindications
Generic Sinemet is contraindicated in patients with the
following conditions:
Known hypersensitivity to Carbidopa or Levodopa or any inactive
component of this medication.
Generic Sinemet should not be used in patients with suspicious,
undiagnosed skin lesions or a history of melanoma
Nonselective monoamine oxidase (MAO) inhibitors are
contraindicated for use with Generic Sinemet.
Side Effects of Generic Sinemet Tablets
The most common adverse effects of Generic Sinemet are
dyskinesias including choreiform, dystonic, and other involuntary
movements and nausea. Muscle twitching and blepharospasm may be
taken as early signs to consider reduction. Other adverse effects
reported in clinical trials or in post-marketing experience are as
follows: Body as a whole: syncope, chest pain, anorexia.
Cardiovascular: cardiac irregularities and/or palpitation,
orthostatic effects including hypotensive episodes, hypertension,
phlebitis.
Side Effects of Generic Sinemet Tablets
Gastrointestinal: vomiting, gastrointestinal bleeding,
development of duodenal ulcer, diarrhoea, dark saliva.
Haematologic: leukopenia, haemolytic and non-haemolytic anaemia,
thrombocytopenia, agranulocytosis. Hypersensitivity: angioedema,
urticaria, pruritus, Henoch-Schonlein purpura. Respiratory:
dyspnoea. Skin: alopecia, rash, dark sweat. Urogenital: dark urine.
Rarely convulsions have occurred;
Side Effects of Generic Sinemet Tablets
Nervous System/Psychiatric: neuroleptic malignant syndrome,
bradykinetic episodes (the "on-off" phenomenon), dizziness,
somnolence including very rarely excessive daytime somnolence and
sudden sleep onset episodes, paresthesia, psychotic episodes
including delusions, hallucinations and paranoid ideation,
depression with or without development of suicidal tendencies,
dementia, dream abnormalities, agitation, confusion.
Side Effects of Generic Sinemet Tablets
Other adverse effects that have been reported with Levodopa or
Levodopa/Carbidopa combinations and may be potential adverse
effects with Generic Sinemet are listed below: Nervous
System/Psychiatric: asthenia, decreased mental acuity,
disorientation, ataxia, numbness, increased hand tremor, muscle
cramps, trismus, activation of latent Horner's syndrome, insomnia,
anxiety, euphoria, falling and gait abnormalities.
Gastrointestinal: dyspepsia, dry mouth, bitter taste, sialorrhoea,
dysphagia, bruxism, hiccups, abdominal pain and distress,
constipation, flatulence, burning sensation of tongue.
Side Effects of Generic Sinemet Tablets
Metabolic: weight gain or loss, oedema. Skin: flushing,
increased sweating, pigmentation of teeth and skin. Urogenital:
urinary retention, urinary incontinence, priapism. Special Senses:
diplopia, blurred vision, dilated pupils, oculogyric crises.
Miscellaneous: weakness, faintness, fatigue, headache, hoarseness,
malaise, hot flashes, sense of stimulation, bizarre breathing
patterns, malignant melanoma.
Warnings And Precautions
When Generic Sinemet (Carbidopa-Levodopa) is to be given to
patients who are being treated with levodopa, levodopa must be
discontinued at least twelve hours before therapy with Generic
Sinemet (Carbidopa-Levodopa) is started.
Levodopa alone, as well as Generic Sinemet, is associated with
dyskinesias. The occurrence of dyskinesias may require dosage
reduction
As with levodopa, Generic Sinemet may cause mental disturbances.
These reactions are thought to be due to increased brain dopamine
following administration of levodopa. All patients should be
observed carefully for the development of depression with
concomitant suicidal tendencies.
Warnings And Precautions
Generic Sinemet should be administered cautiously to patients
with severe cardiovascular or pulmonary disease, bronchial asthma,
renal, hepatic or endocrine disease.
As with levodopa, care should be exercised in administering
Generic Sinemet to patients with a history of myocardial infarction
who have residual atrial, nodal, or ventricular arrhythmias. In
such patients, cardiac function should be monitored with particular
care during the period of initial dosage adjustment, in a facility
with provisions for intensive cardiac care.
Warnings And Precautions
As with levodopa, treatment with Generic Sinemet may increase
the possibility of upper gastrointestinal hemorrhage in patients
with a history of peptic ulcer.
Neuroleptic Malignant Syndrome (NMS): Sporadic cases of a
symptom complex resembling NMS have been reported in association
with dose reductions or withdrawal of therapy with Generic Sinemet.
Therefore, patients should be observed carefully when the dosage of
Generic Sinemet (Syndopa Tablets) is reduced abruptly or
discontinued, especially if the patient is receiving
neuroleptics.
Overdose Symptoms
Reported symptoms two hours after ingestion of 60 tablets of
25-250 Generic Sinemet were sinus tachycardia, nausea and vomiting.
Supportive therapy has to be instituted.Electrocardiographic
monitoring should be instituted and the patient carefully observed
for the possible development of arrhythmias; if required,
appropriate antiarrhythmic therapy should be given.
Syndopa Tablets from Sun Pharmaceutical Industries Ltd.,
India
For more information click here
Generic Sinemet Tablets
The Swiss Pharmacy, Geneva Switzerland
