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Sagittally oriented safranin-O–stainedsections of an adult human lumbar intervertebraldisk (top) and a degenerated intervertebral disk(bottom). Disk matrix stains purple and collagenblue. In the adult disk, the peripheral annulus fibrosus,containing collagen, stains blue (arrowhead).The inner annulus fibrosus and nucleus pulposus,containing GAGs, stains purple. The central portionof the nucleus pulposus, where reticulin, collagen,and elastin fibers are located, stains faintly blue.The degenerated disk has lost purple-staining GAGsfrom the nucleus pulposus and annulus fibrosus. Itconforms to Pfirrmann grade IIII degeneration.
47 year old woman with 6 month h/o neck stiffness and pain with left UE paresthesias intoThe elbow forearm and hand especially IF/thumb
Note:the black line directly posterior to the vertebral bodies and relativeThinning of spinal cord, note normal disc height
Mid-sagittal diameter: width1:5 ratio leads to necrosis of gray matter• Ogino H: Canal diameter, anteroposterior compression ratio
and spondylotic myelopathy of the cervical spine. Spine 1983; 8:1-15• Cord compression causes ischemia and direct mechanical
trauma
• Raymond Damadian from Downstate NY published an article in Science 1971 on a technique to differentiate cancer and nomral cells with an MRI. He filed the first USP patent for an MRI on 3/17/72’ he created the first Mri machine
Peter Lauterburchemist at Universtiy of Illinois
created and published the first MRI image of a living mouse in 1973
• Physicist Peter Mansfield of the Universtiy of Nottingham developed a mathemantical technique to refine inages
20033
• Wilhem Rontgen 1845-1923• 1895 xray discovery• German physicist• Expelled from high school for
refusing to reveal a classmate who created a disparaging drawing of a teacher