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Japan cardiovascular market at a glance Yuji Segawa All rights reserved Yuji Segawa All Rights Reserved

Japan cardivascular at a glance

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Page 1: Japan cardivascular at a glance

Japan cardiovascular market at a glanceYuji Segawa All rights reserved

Yuji Segawa All Rights Reserved

Page 2: Japan cardivascular at a glance

Professional consultancy is provided through Guidepoint Global

Yuji Segawa All Rights Reserved

Page 3: Japan cardivascular at a glance

Trends of number of patient and diseased rate

0

500

1,000

1,500

2,000

2,500

1999 2002 2005 2008 2011

Ischemic cerebrovascular disease

Peripheral

Ischemic heart disease

0

50

100

150

200

250

300

350

1999 2002 2005 2008 2011

Ischemic cerebrovascular disease

Peripheral

Ischemic heart disease

# of patientThousands, each Oct.

Diseased ratePer 100 thousand person

Source ; MHLW

• Number of patients are decreasing • Diseased rates are decreasing

Yuji Segawa All Rights Reserved

Page 4: Japan cardivascular at a glance

Trends of # of patients, detail data

1999 2002 2005 2008 2011

Ischemic heart disease

Angina pectoris 727 691 648 604 558

Acute myocardial infarction 82 51 41 49 41

Coronary artery sclerosis 20 9 6 5 5

Old myocardial infarction 96 81 105 89 110

Peripheral Peripheral embolism 18 18 14 12 15

Ischemic cerebrovascular disease

Cerebral infarction 1,120 1,064 1,052 964 924

cerebral arteriosclerosis 28 11 6 6 13

Total 2,091 1,925 1,872 1,729 1,666

Source ; MHLW

# of patient Thousands, each Oct.

Yuji Segawa All Rights Reserved

Page 5: Japan cardivascular at a glance

Trends of diseased rate, detail data

1999 2002 2005 2008 2011

Ischemic heart disease

Angina pectoris 63 56 53 49 44

Acute myocardial infarction 10 7 7 7 6

Coronary artery sclerosis 2 1 0 0 0

Old myocardial infarction 8 6 8 7 8

Peripheral Peripheral embolism 3 2 2 2 2

Ischemic cerebrovascular disease

Cerebral infarction 213 202 201 170 149

cerebral arteriosclerosis 4 2 1 1 1

Total 303 276 272 236 210

Source ; MHLW

Diseased rate Per 100 thousand person

Yuji Segawa All Rights Reserved

Page 6: Japan cardivascular at a glance

Trends of PCI

2009 2010 2011 2012 2013

Emergency PCI 59,234 64,333 67,207 68,749 68,254

Planned PCI 161,978 183,661 181,991 184,877 185,072

# of sample 1,524 1,646 1,676 1,612 1,535

Total PCI 221,212 247,994 249,198 253,626 253,326

PCI per one 145 151 149 157 165

PCI reaches out a peak

Source ; The Japanese circulation Society Yuji Segawa All Rights Reserved

Page 7: Japan cardivascular at a glance

Market volume trends; Anti-blood clot drugs; Million JPY, each Julantiplatelet+ Anticoagulant

0

1,000

2,000

3,000

4,000

5,000

6,000

7,000

1999 2002 2005 2008 2011 2013

Total GE

PlavixAspirin ComplavinEfientAnticoagulant

drug launch rush

Source ; MHLW, and Jiho Yuji Segawa All Rights Reserved

Page 8: Japan cardivascular at a glance

Trends of number of potential patient

1999 2002 2005 2008 2011

Insulin-independent diabetes mellitus 743 1109 1402 1250 1663

Hyperlipemia 1140 1391 1530 1433 1886

Depression 441 711 924 1041 958

Hyperpiesia 6979 6837 7693 7834 8986

Chronic Kidney failure 185 223 257 331 343

# patients are increasing

Source ; MHLW Yuji Segawa All Rights Reserved

Page 9: Japan cardivascular at a glance

KOL trends

Professional consultancy is provided through Guidepoint Global

Yuji Segawa All Rights Reserved

Page 10: Japan cardivascular at a glance

Detail therapeutic development and output

Professional consultancy is provided through Guidepoint Global

Yuji Segawa All Rights Reserved