Presented ByMr. Mitkari Jayshankar V.

M. Pharm. ( Pharmaceutics Department )

Under the guidance Of

Mrs. Bidkar S. J.

Sharadchandra Pawar college of Pharmacy, Otur, Pune.

Pharmaceutical Packaging Materials

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INTRODUCTION Packaging is the science, art and technology of enclosing

or protecting products for distribution, storage, sale, and use.

Pharmaceutical packaging can be defined as the economical means of providing presentation, protection, identification , information, convenience ,compliance , integrity and stability of the product .

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FUNCTIONS OF PACKAGING

• Product Identification• Product Protection• Facilitating the use of product• Product Promotion

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TYPES OF PACKAGING

Primary packaging- Is the material that first envelops the product and hold it.

Ex. Aerosol spray can, blister packs, bottle

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Secondary packaging -Is outside the primary packaging Ex. Boxes, cartons

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Tertiary packaging- Is used to bulk handling and shipping.

Ex. Barrel, container, edge protector

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SOLID DOSAGE FORM (TABLETS, CAPSULES, POWDERS)Glass Bottles• type III glass and NP glass is used.• Transparent and Amber coloured glass bottle Plastic Bottle :• Bottles made from polyethylene, Polypropylene , Polystyrene.• It is light weighted and non breakable.

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Blister packaging: Forming cavity or pocket Polyvinyl chloride (PVC). Backing membrane seal of aluminum foil

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Strip Packaging Strip packs for a unit dosage. Made from cellulose, paper, plastic, foil or

combination of these

The use of high barrier material like aluminum foil or saran-coated film with excellent seal formation for moisture-sensitive products.

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Pouches

Plastic Pouches :  With a re-sealable strip at the top,

easy to open and close It have Waterproof, tide proof, air

proof and non-poisonous property .

Aluminum pouches :1. It have tear strip facility2. It offers excellent barrier properties

to the moisture, gas and light

Plastic Pouches

Aluminium pouches

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Solids-Rectal (Suppository) :

1) Aluminum Foil Offers the highest possible protection

against moisture, oxygen, and light,. The aluminum suppository package takes the

shape of individual doses .

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2) Laminates for suppositories :

• It is made of Polyolefine, Aluminum, P.E. .

• It gives protection from moisture, gas ,vapors, light

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Solids (Inhalation) Dry-Powder Inhaler :• It is made of plastics such as polyethylene (HDPE), Polypropylene ,

polystyrene .

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LIQUID DOSAGE FORM- Glass Or Plastic Bottle - Bottle With Spray PumpCapacity: 50ml

Material: Bottle-polyethylene terephthalate; Sprayer-polypropylene

Spray output: 0.05ml-0.20ml

Used for body spray, oral spray, anti-bacterial spray.

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Bottle With Dropper Assembly:

• Dropper assemblies can be supplied with

coloured caps

• glass type II is used

• Dropper glass is of Sodalime glass(type III) and Neutral glass(type I).

• Bottle capacity is from 2 to 100ml

• pipettes are up to 120mm in length

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Aerosol spray :Container: To withstand pressure 140-180 psi 1) Tin plate container- it is sheet of steel plates electroplated on both side with tin

2) Aluminum container- it has seamless nature and greater resistance to corrosion

3)Stainless steel container –used inhalation aerosol 4)Glass container – type I glass is used

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STERILE PRODUCTS Glass Ampoules :• Type I (borosilicate glass is used)• Up to 3 colour can be placed for identification purpose.• PVC mono films used for 20 packaging.

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Vial With Stopper :

• Vials are mainly used for multiple dose parenteral preparation and are provided with the closure followed by aluminum seal to ensure the perfect air tight packing

Closure:

• Made from Butyl rubber ,Nitrile rubbers ,Neoprene, Silicon rubbers.

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- Pre-Filled Syringe:

• It is used for small volume parenteral preparation.

• Reduction of medication errors like drug overfill.

• It gives Increased assurance of sterility

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Sterile plastic devices :

Irrigation solution container :

• It is made of Polyolefin , polypropylenes

• It is light in weight, transparent, impermeable to

water

• Material have high boiling point so that it is sterilizable .

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OPHTHALMIC DOSAGE FORM

1) Plastic bottles:• Material used for plastic bottle is low density polyethylene,

• for caps are harder plastic materials such HighdensityP.E. or Polypropelene is used.

2) Collapsible Tube

3) blow-Fill-Seal Plastic Bottle

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Pouching Materials

There are three main layers in the composite materials used for pouches:

1) Internal plastic heat sealable layer, - material used -polyethylene, surlyn

2) Aluminium foil layer – Its important role in protecting the product from light and oxygen.

3) External printable layer. It is used to achieve a better 'finishing' and printing quality material- Paper or polyester film is used

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Opti-nose device :

• In this , air is blown out of the container and sealing nozzle is used its direct flow of air in nose

• It gives bi-directional flow so that it prevents deposition of drug in lungs.

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Direct-haler device :

for turbulent dispersion of dose

for moisture protection

Transparency of

divice for drug

visibility

REFERENCE Lachman, Libarman; “The theory and practice of industrial

pharmacy”, third edition, varghese publishing house

Jain U.K., Nayak S.; “Pharmaceutical packaging technology” PharmaMed Press

Dean D.A., Hall I.H.; “Pharmaceutical packaging technology” Taylor and Francis

Hanlon F. J., “Handbook of package engineering”, second edition, Technomic Publishing CO. ING

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“ THANK –YOU”All