Kaposi Sarcoma

Brajesh LahriFinal Professional MBBSAll India Institute of Medical Sciences(AIIMS),Bhopal

Introduction

Intermediate grade tumour

Rare in general population

Commonly seen in AIDS patients

Types

4 Types

1. Chronic

2. Lymphadenopathic

3. Transplant associated

4. AIDS associated

Pathogenesis

Infection of Endothelial

cells by KSHV

•Causes Lytic as well as latent infection of Endothelial cells

Creation of locally proliferative milieu by

cytokines and disruption of normal cell proliferation.

•Causing abnormal cellular proliferation and local proliferative environment

Increased growth and proliferation

of cells

Clinical Features

Macules and Patches

Raised Plaques (Violaceous)

Nodules

Treatment

Surgical Resection

Radiation

Chemotherapy

Anti-retroviral drugs

IFN-A and angiogenesis inhibitors

Thank You