WHAT IS HEALTH IN GUM®?

It’s a ready-to-use powder excipient specially developed for functional or medicated chewing gum It’s a mix of Gum Base and polyols to which you can add an active ingredient and produce compressed chewing gum using standard tableting equipment

WHY USE CHEWING GUM AS A DRUG DELIVERY SYSTEM? Medicated chewing gum provides new competitive advantages over conventional drug delivery system: Fast onset of action and high bioavailability Pleasant taste Higher compliance (easy and discreet administration without water) Ready for use

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MEDICAL USES OF MEDICATED CHEWING GUM®

Medicated Chewing Gum (MCG) is a novel drug delivery system containing Gum Base and an pharmaceutical principal ingredient Chewing gum gained acceptance as a reliable drug delivery system from 1978, when nicotine chewing gum became available. In 1991, was approved as a term for pharmaceutical dosage form by the commission of European Council Medicated Chewing Gum (MCG) today is increasing its consideration as a vehicle or a delivery system to administer active principles that can improve health and nutrition

APPLICATIONS OF THE MEDICATED CHEWING GUM® Oral diseases are prevented or cured with Medicated Chewing Gum MCGs possible uses include:

LOCAL THERAPY SYSTEMIC THERAPY

LOCAL THERAPY 1 Fluoride

Fluoride containing gums have been useful in preventing dental caries in children

2 Xerostomia Dry mouth is a side effect of many types of medicament (e.g. antidepressants) and it is also part of the symptomatology of several diseases

LOCAL THERAPY 3 Chlorhexidine

Medicated chewing gum can be used to treat gingivitis, periodontitis, oral and pharyngeal infections. It can also be used for inhibition of plaque growth Clinical trials involving patients with oral candidiasis have shown that miconazole chewing gum is at least as sufficient as miconazole oral gel in the treatment of fungal infections in the mouth.

SYSTEMIC THERAPY

4 Chewing gum can be used in treatment of minor pains, headache and muscular aches Chewing gum formulation containing nicotine have been clinically tested as aids to smoking cessation Active substances like chromium, guaran and caffeine are proved to be efficient in treating obesity Xerostomia, allergy, motion sickness, acidity, cold and cough, diabetes, anxiety, etc are all indications for which chewing gum is a means of drug delivery

Prashant K. Pagare, Chandrakant S. Satpute, Varsha M. Jadhav and Vilasrao Kadam. Medicated Chewing Gum: A Novel Drug Delivery System. In Journal of Applied Pharmaceutical Science 02 (06); 2012: 40-54, ISSN: 2231-3354. Available online at www.japsonline.com

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